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Oral ulcer film with repairing effect and preparation method of oral ulcer film

A technology for oral ulcers and repairing effect, applied in the field of oral care, can solve problems such as complex production process, and achieve the effects of simple and safe ingredients, obvious repairing effect, and simple and convenient production process

Inactive Publication Date: 2020-12-22
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that most oral ulcer patches in the prior art use medicinal ingredients as the main therapeutic ingredients, and the production process is complicated, the present invention provides a oral ulcer patch with repairing effect and a preparation method thereof

Method used

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  • Oral ulcer film with repairing effect and preparation method of oral ulcer film
  • Oral ulcer film with repairing effect and preparation method of oral ulcer film
  • Oral ulcer film with repairing effect and preparation method of oral ulcer film

Examples

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preparation example Construction

[0040] The present invention also provides a preparation method of oral ulcer patch with repairing effect, such as figure 1 As shown, the simple summary can include the preparation of phase A and phase B, after mixing phase A and phase B, sterilization, laying, drying, and cutting to obtain oral ulcer veil. Specifically, the method includes the following steps:

[0041] Dissolving hyaluronic acid, ectoine, ergothioneine and pentylene glycol in water to obtain phase A;

[0042] Dissolving chitosan, polyvinyl alcohol and glycerin in water to obtain phase B;

[0043] Mix phase A and phase B to obtain a colloid;

[0044] The colloid is sterilized, plated, dried and cut to obtain a repairing oral ulcer patch.

[0045] In a specific embodiment, in the phase A, the mass ratio of the hyaluronic acid, the ectoine and the ergothioneine is 1:(0.1-3):(0.1-2), Preferably it is 1:(0.5-1.5):(1-2). The mass ratio of pentanediol to the hyaluronic acid is (0.5-4):(5-15).

[0046] In a speci...

Embodiment 1

[0055] (1) Dissolve 1g of hyaluronic acid (including 0.5g of 1000kDa high molecular weight hyaluronic acid and 0.5g of 400kDa low molecular weight hyaluronic acid), 1g of ectoine, 1.5g of ergothioneine and 2g of pentanediol in 50ml Mix well in deionized water to obtain Phase A;

[0056] (2) Add 14g of polyvinyl alcohol into 50ml of deionized water, fully swell overnight, heat to 85°C to dissolve, cool, add 5g of chitosan and 1.5ml of glacial acetic acid when it cools to room temperature, stir at room temperature until completely dissolved, and finally Add 1 g of glycerin, stir and mix at room temperature to obtain phase B;

[0057] (3) Phase A and Phase B are mixed to obtain a colloid. The obtained colloid was sterilized at 121° C. for 8 minutes, and spread on a paraffin-coated and sterilized glass plate. Dry the glass plate at 45°C for 2.5 hours, then peel off the film, cut and pack to obtain the oral ulcer film.

Embodiment 2-6

[0059] Compared with Example 1, the difference of Examples 2-6 is that the addition amounts of high-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid, ectoine and ergothioneine are different, and the specific addition amounts are shown in Table 1. Among them, the total amount of the three functional substances of hyaluronic acid, ectoine and ergothioneine is the same, 3.5g. Other operating steps and reaction conditions are with embodiment 1.

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Abstract

The invention discloses an oral ulcer film with a repairing effect, and relates to the field of oral ulcer repairing. The oral ulcer film with the repairing effect comprises the following raw materials of a film-forming agent, a humectant and functional substances, wherein the functional substances are hyaluronic acid, ectoine and ergothioneine with anti-inflammatory, bactericidal and repairing effects. According to the oral ulcer film, a preparation process is simple, the cost is low, the film-forming property is good, the safe and effective effects are achieved, the raw materials are easy toobtain, and the large-scale production can be achieved; and compared with a traditional oral ulcer film, the oral ulcer film containing the functional substances does not contain any medicinal substances, has no irritating effect on an oral ulcer surface, is simple, safe and free of toxic and side effects in components, can be attached to the ulcer surface, has the effects of bacteria blocking, inflammation resistance and repairing, and can effectively promote ulcer healing, repair and protect wounds, and prevent infection.

Description

technical field [0001] The invention belongs to the field of oral care, and in particular relates to a repairing oral ulcer film and a preparation method thereof. Background technique [0002] In recent years, human beings have not only paid attention to some large diseases such as tumors and cancers, but also a large number of diseases such as stomatology. Oral ulcer is the most common oral mucosal disease in clinical practice. It is generally found in all parts of the oral mucosa, mainly in the inner lip, tongue, buccal mucosa, vestibular groove, soft palate and other parts. Oral ulcers are often accompanied by severe pain, especially local burning pain when eating Obviously, in severe cases, it will also affect daily life, causing inconvenience and distress. At the same time, it will also cause systemic symptoms such as bad breath, chronic pharyngitis, and swollen lymph nodes. Oral ulcers are often recurrent, and their occurrence is also the result of a combination of fa...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K31/505A61K31/4172A61K9/70A61P1/02A61P31/02A61P31/04A61P31/10
CPCA61K9/006A61K9/7007A61K31/4172A61K31/505A61K31/728A61K47/36A61P1/02A61P31/02A61P31/04A61P31/10A61K2300/00
Inventor 张燕李琳刘建建庄心蕊潘存才郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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