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Medical conductive hyaluronic acid gel as well as preparation method and application thereof

A conductive, transparent, hyaluronic acid technology, applied in applications, electrotherapy, pharmaceutical formulations, etc., can solve the problems of poor biocompatibility of preservatives, incomplete response, irritation, etc., achieve good biocompatibility, improve infiltration ability, good biocompatibility

Active Publication Date: 2021-01-01
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this hydrogel has good stability and conductivity, the reaction is not complete during the replacement process, which may easily cause monomer residues on the surface of the gel, and will still cause certain damage and irritation to the surface of the skin.
In addition, due to the viscoelastic properties of the gel, the permeability of the hydrogel will be poor, the contact impedance will increase, and the electrical signal will be insensitive, which will have a bad effect on the conductivity of the hydrogel, making it difficult for signal acquisition. has application limitations
[0004] CN105199631A discloses a natural biodegradable medical conductive gel and its preparation method. It is made from high polymer, preservative, penetrant and purified water, wherein the high polymer is polysaccharide sodium alginate, and the preservative is Sodium benzoate and niplatin, the efficacy of polymers and preservatives in raw materials are greatly affected by pH, and the residual preservatives have poor biocompatibility and are irritating to the surface of human skin

Method used

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  • Medical conductive hyaluronic acid gel as well as preparation method and application thereof
  • Medical conductive hyaluronic acid gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The raw materials of the medical conductive hyaluronic acid gel of the present invention are (parts by weight): 4 parts of sodium hyaluronate; 1.0 parts of conductive medium: 0.6 parts of calcium chloride and 0.4 parts of Zn-diacid coordination polymer; 0.3 parts of surfactant Parts: 0.15 parts of sodium cocoamphoacetate and 0.15 parts of fatty acid glycerides; 4 parts of glycerin; 0.9 parts of lutein; 30 parts of phosphate buffer (pH = 5.7); 40 parts of water.

[0046] The preparation method of the Zn-diacid coordination polymer used is as follows:

[0047] 1) Add zinc sulfate and 2,5-thiophene dicarboxylic acid into the solvent water at a molar ratio of 1:2, and mix well by ultrasonic;

[0048] 2) Transfer the mixed suspension to the reaction kettle, and transfer the reaction kettle with the reaction system solution to the electric heating constant temperature blast drying oven;

[0049] 3) Set the oven parameters: temperature: 80°C, time: 360 min.

[0050] 4) After...

Embodiment 2

[0058] The raw materials of the medical conductive hyaluronic acid gel of the present invention are (parts by weight): 4 parts of sodium hyaluronate, 1.0 parts of conductive medium: 0.8 parts of calcium chloride, 0.2 parts of Zn-diacid coordination polymer, and 0.3 parts of surfactant Parts: 0.15 parts of sodium cocoamphoacetate, 0.15 parts of fatty acid glycerides, 4 parts of glycerin, 0.9 parts of lutein, 30 parts of phosphate buffer (pH = 5.7), 40 parts of water.

[0059] The preparation method is the same as in Example 1.

Embodiment 3

[0061] The raw materials of the medical conductive hyaluronic acid gel of the present invention are (parts by weight): 4 parts of sodium hyaluronate; 1.0 parts of conductive medium: 0.6 parts of calcium chloride and 0.4 parts of Zn-diacid coordination polymer; 0.3 parts of surfactant Parts: 0.1 parts of sodium cocoamphoacetate and 0.2 parts of fatty acid glycerides; 4 parts of glycerin; 0.9 parts of lutein; 30 parts of phosphate buffer (pH = 5.7); 40 parts of water.

[0062] Prepare Zn-diacid coordination polymer according to the method of Example 1, the difference is: 2,5-thiophene dicarboxylic acid is replaced by maleic acid, the preparation method of medical conductive hyaluronic acid gel is the same as that of Example 1.

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Abstract

The invention discloses medical conductive hyaluronic acid gel as well as a preparation method and application thereof. The medical conductive hyaluronic acid gel is prepared from the following raw materials of hyaluronic acid or salt thereof, a conductive medium, a surfactant, glycerol, xanthophyll, a phosphate buffer solution and water. The medical conductive hyaluronic acid gel is free of preservatives, good in biocompatibility, non-toxic, non-irritant and excellent in conductivity, overcomes the defects that the hyaluronic acid gel is easy to degrade in a short time and too high in degradation rate, reduces the degradation rate of the hyaluronic acid gel, and further has lubricating and moisturizing effects. The medical conductive hyaluronic acid gel has a good application prospect inhuman body electrophysiological signal acquisition, and can be used for acquisition of fetal electrocardiogram, myoelectricity and electroencephalogram signals.

Description

technical field [0001] The invention relates to a medical conductive hyaluronic acid gel and its preparation method and application, in particular to a medical conductive hyaluronic acid gel with good biocompatibility, no stimulation to the skin, antibacterial and high sensitivity, its preparation method and The invention belongs to the technical field of medical conductive materials. Background technique [0002] At present, medical conductive paste or medical conductive gel is a common connection between the human body and medical electrodes. It is used on the contact surface of the power connector to reduce resistance and obtain accurate monitoring data. Therefore, conductive paste or conductive gel has important application value in the field of medical devices. Medical conductive paste is mainly composed of polymer thickening substances, conductive inorganic salts, and organic polymer conductive substances. In order to improve conductivity, it generally needs to contai...

Claims

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Application Information

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IPC IPC(8): A61K50/00
CPCA61K9/0009C09J9/02
Inventor 庄心蕊刘建建张燕李琳郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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