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Capsule for improving intestinal flora of hypertension patient

A technology of capsules and capsule shells, which is applied in the fields of capsule delivery, medical preparations containing non-active ingredients, and medical preparations containing active ingredients. Halal food conflicts and other issues, to achieve the effect of improving vitality and intestinal colonization rate, fast and convenient consumption, and conducive to efficient colonization

Active Publication Date: 2021-01-05
SHENZHEN AUSA PHARM CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the probiotic capsules on the market use ordinary gelatin capsules as the capsule coating, and there is no capsule shell developed for the specific enteric coating requirements of probiotics, such as the two probiotic capsules published in patent CN104719889A and patent CN105287649A, and gelatin capsules contain probiotics. The hidden danger of virus infection and the resistance to certain religious halal food requirements have also affected the consumer acceptance of this type of probiotic capsules

Method used

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  • Capsule for improving intestinal flora of hypertension patient
  • Capsule for improving intestinal flora of hypertension patient
  • Capsule for improving intestinal flora of hypertension patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation and disintegration performance of tamarind gum probiotic capsule enteric-coated capsule shell

[0033]1) Sol: Take 16 parts of tamarind gum, 10 parts of sodium alginate, 2 parts of Eudragit (L30D-55), 60000.5 parts of polyethylene glycol, add 250 parts of water, heat up to 70-90 ° C, and keep stirring to make it fully Swell and dissolve after absorbing water, and then stand at 55-75°C for 2-4 hours to clarify the glue.

[0034] 2) Heating: Heat the clarified glue solution to 80-98°C, add 5 parts of potassium acetate, 5 parts of calcium chloride, and 1 part of glycerin, dissolve and stir for 2 hours, so that all components are fully mixed to achieve uniformity.

[0035] 3) Dipping in glue to make embryos: the temperature of the glue solution is lowered to 72°C, and after the air bubbles have been stably removed, use a standard 1# capsule to touch, and dip the upper end of the mold rod downward into the glue solution, and wait for the glue solution ...

Embodiment 2

[0042] Example 2: Preparation and Survival Rate of Freeze-dried Probiotic Powder in Tamarind Gum Probiotic Capsule Contents

[0043] 1) Activation of strains: Take Lactobacillus acidophilus and Bifidobacterium as examples:

[0044] Lactobacillus: Inoculate Lactobacillus acidophilus strains in sterilized MRS liquid medium, culture at 37°C for 48 hours, then inoculate new sterilized MRS liquid medium at a ratio of 5.0% by volume, and cultivate for 48 hours under the same conditions Obtain the second-grade strains, carry out another subculture with the same ratio and culture conditions, and obtain the third-grade activated bacterial liquid for production;

[0045] Bifidobacteria: Inoculate Bifidobacterium animal species into sterilized BBL liquid medium, after anaerobic culture at 37°C for 48 hours, inoculate into new sterilized BBL liquid medium at a ratio of 5.0% by volume, under the same conditions Under culture for 48 hours to obtain the second-grade strains, the same ratio ...

Embodiment 3

[0054] Example 3: Tamarind Gum Probiotic Capsules Improves the Intestinal Flora of Hypertensive Dogs

[0055] 26 male Beagle dogs, weighing 9.5-11.0kg, ordinary grade, kept in single cages, and the cages were cleaned daily. Real animals were fed quantitatively and had free access to water. The temperature is 16-26°C, the daily temperature difference is ≤4°C, the relative humidity is 40-70%, the number of air changes is 8-10 times / hour, and the light and dark time are 12 hours each day.

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Abstract

The invention relates to a vacuum freeze-dried probiotic capsule prepared from an enteric capsule shell containing tamarind gum and a preparation technology of the vacuum freeze-dried probiotic capsule. The invention provides a new thought of a dietary fiber compound probiotic product. The enteric capsule shell takes the tamarind gum and sodium alginate as main materials, and Eudragit (L30D-55) isadded, so that the cost is low, the process is feasible, and the enteric capsule shell is suitable for industrial popularization. A vacuum freeze-drying technology is adopted for probiotic powder, and inulin is added into a freeze-drying protective agent, so that the stress resistance of probiotics is enhanced, and the colonization rate of the probiotics after intestinal disintegration is increased. The tamarind gum and the inulin are two non-digestible dietary fibers, have the characteristics of prebiotics which cannot be metabolized by the human body and can be glycolyzed by the probiotics,are very suitable for being compounded with the probiotics, and are applied to preparation of the capsule shell and the freeze-drying protective agent, so that full utilization of the raw materials is realized.

Description

technical field [0001] The invention belongs to the field of probiotic preparations, in particular to a vacuum freeze-dried probiotic capsule made of an enteric-coated capsule shell containing tamarind gum and a preparation technology thereof. Background technique [0002] The intestinal flora is an important immune organ of the human body and an important barrier against foreign toxins, especially food-borne harmful substances. The intestinal flora is gradually established and improved with the growth and development of human beings. The intestinal flora of infants and young children is not fully developed, and they are especially susceptible to infection by foreign pathogens. The phenomenon of antibiotic abuse is common in China and the world. In 2013, China's antibiotics The consumption is as high as 162,000 tons, accounting for about half of the world's consumption. The abuse of antibiotics directly destroys the balance of intestinal flora and induces the emergence of d...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/46A61K47/36A61K47/32A61K47/18A61K35/741A61P1/00
CPCA61K9/4816A61K35/741A61K47/183A61P1/00
Inventor 姜城子于多白洁邢厚恂王滨燕宋昀
Owner SHENZHEN AUSA PHARM CO LTD
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