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A kind of hollow carbon nanocomposite material integrated with diagnosis and treatment and its preparation method and application

A composite material, carbon nanotechnology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, drug combinations, etc., can solve problems affecting diagnostic accuracy, confusion, tissue calcification, etc. safety effect

Active Publication Date: 2021-09-28
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent CN 111494627 A discloses a light, heat and magnetic composite material based on hollow carbon spheres, based on hollow nanoparticles UCNPs / Fe coated with hollow carbon shells 3 o 4 @h-C, UCNPs and Fe 3 o 4 Nanoparticles were introduced into the interior of hollow carbon spheres, and the prepared hollow carbon-coated UCNPs and Fe 3 o 4 Synthesized nanoparticles with core-shell structure, although they can meet certain needs of integration of photothermal therapy and imaging diagnosis and treatment, in MRI, only negative contrast agent T 2 , its detection signal is easily confused with metal deposition, tissue calcification, etc., which affects the accuracy of diagnosis

Method used

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  • A kind of hollow carbon nanocomposite material integrated with diagnosis and treatment and its preparation method and application
  • A kind of hollow carbon nanocomposite material integrated with diagnosis and treatment and its preparation method and application
  • A kind of hollow carbon nanocomposite material integrated with diagnosis and treatment and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0046] 1) The specific process is as follows: the purchased commercial SiO 2 (70-80nm) 10mg was dispersed in 50mL ethanol solution, after stirring at room temperature for 1h, 0.6g of resole phenolic resin (RF) solution with a concentration of 160mg / mL was added. After continuing to stir for 24h, the mixture was transferred to an 80mL reactor, and subjected to hydrothermal reaction at 100°C for 24h. After cooling to room temperature, the obtained sample was centrifuged and washed with water, and then dried in an oven at 60°C for 12 hours to obtain SiO 2 @RF polymer pellets.

[0047] 2) 6mg{Fe 6 Gd 6 P 6} sonicated into 2 mL of ethanol solution, and to this solution was added 20 mg of SiO 2 @RF, sonication makes it uniform in ethanol solution. The mixed solution was stirred and evaporated to dryness at room temperature to obtain SiO 2 @RF-{Fe 6 Gd 6 P 6} composite material.

[0048] 3) Put the above-mentioned obtained material in a tube furnace, roast at 600 ° C for 1...

Embodiment 3

[0064] The biopsy tissue slice test of the sample in Example 3, the method is as follows: take the tissue organs of nude mice after injecting the nanocomposite material for 24 hours, wash them with normal saline or PBS, put them into 4% paraformaldehyde for fixation, and dehydrate Transparent, wax-soaked, embedded, trimmed, sliced, patched, fished, baked, dewaxed to water, dyed, dehydrated, mounted and photographed, such as Figure 8 shown.

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Abstract

The invention relates to the technical field of functional nanomaterials, in particular to a hollow carbon nanocomposite material integrating diagnosis and treatment and a preparation method thereof. The hollow carbon nanocomposite material of the present invention satisfies the requirement of photoacoustic imaging due to its hollow structure. At the same time, paramagnetic gadolinium phosphate nanoparticles and superparamagnetic gamma iron oxide nanoparticles are evenly distributed in the shell of hollow carbon, satisfying T 1 weighted imaging and T 2 weighted imaging requirements. On the other hand, due to their own porosity, hollow carbon materials can be used as drug carriers to realize the function of drug delivery. Therefore, the nanomaterial provided by the invention realizes T 1 , T 2 The integration of magnetic resonance imaging, photoacoustic imaging and drug delivery. The biosafety of the obtained nano-medicine integrated material has been verified at the cell level and the mouse level, and has potential application prospects.

Description

technical field [0001] The invention relates to the technical field of functional nanomaterials, in particular to a hollow carbon nanocomposite material integrating diagnosis and treatment, a preparation method and application thereof. Background technique [0002] With the continuous development of nano-material technology, tumor treatment technology (including: chemical drug therapy, gene therapy, photodynamic therapy, photothermal therapy, immunotherapy, etc.) and tumor diagnostic methods (including: nuclear magnetic resonance imaging, photoacoustic imaging , positron emission tomography, computed tomography, etc.) are integrated into a material through modern nanosynthesis technology to achieve functional integration, which is not only conducive to patient stratification and personalized medicine, but also to real-time monitoring of nanomedicine therapy. Therefore, the development of integrated nanomaterials for diagnosis and treatment is one of the development direction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K49/08A61K49/22A61K9/51A61K47/04A61K31/704A61P35/00
CPCA61K9/5115A61K31/704A61K49/08A61K49/18A61K49/225A61P35/00
Inventor 凌云周亚明刘小锋杨永泰贾瑜陈珍霞邓名莉张慧
Owner FUDAN UNIV