A multifunctional natural polysaccharide repairing adhesive hydrogel, its preparation method and its application in the preparation of medicines for treating skin damage

A natural polysaccharide, multi-functional technology, applied in the field of material science, can solve the problems of sepsis and even osteomyelitis, and achieve the effect of shortening the gelation time, reducing the damage of the subcutaneous tissue, and reducing the viscosity

Active Publication Date: 2021-08-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in people's daily life, skin cuts and burns are almost inevitable, and open wounds can easily lead to sepsis and even osteomyelitis. Preventing wound infection and promoting rapid wound repair are two major challenges in the field of trauma therapy

Method used

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  • A multifunctional natural polysaccharide repairing adhesive hydrogel, its preparation method and its application in the preparation of medicines for treating skin damage
  • A multifunctional natural polysaccharide repairing adhesive hydrogel, its preparation method and its application in the preparation of medicines for treating skin damage
  • A multifunctional natural polysaccharide repairing adhesive hydrogel, its preparation method and its application in the preparation of medicines for treating skin damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of the chitosan of catechol modification

[0030] Add 3g chitosan and 300mL, 1mol / L HCl into a 500mL Erlenmeyer flask, stir thoroughly for 2 days, and after fully dissolved, adjust the pH of the solution to 4.5 with 1mol / L NaOH to obtain solution A. Dissolve 2.17g of dihydroxyphenylpropionic acid in 25mL of deionized water, and slowly drop it into solution A after being fully dissolved. During this process, continuous stirring is required to obtain solution B. Take 2.48 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and dissolve it in 50 mL of water and ethanol solution (the volume ratio of water and ethanol is 1:1), and slowly Drop into solution B, adjust the pH of the solution to 5 with 1mol / L NaOH throughout the whole process, pour the reaction solution into a dialysis bag (cellulose, molecular weight cut-off 12000Da) after reacting for 8 hours, and dialyze with a hydrochloric acid solution of pH=4.5 at room temperature...

Embodiment 2

[0031] Example 2: Preparation of dextran modified by aldylation

[0032] Dissolve 4g of dextran in 320mL deionized water and stir to dissolve fully to obtain a dextran solution; dissolve 4.2g of sodium periodate in 80mL of deionized water to obtain a sodium periodate solution; add the sodium periodate solution to the glucose In the polysaccharide solution, the whole reaction was protected from light for 24 hours, and then poured into a dialysis bag (cellulose, with a molecular weight cut-off of 3500Da), dialyzed with deionized water at room temperature for 3 days, and replaced the deionized water 3 times a day. The dialysate was frozen in liquid nitrogen and then frozen. Dry and store at -80°C to obtain aldehyde-modified dextran.

Embodiment 3

[0033] Embodiment 3: the preparation of skin restoration adhesive

[0034] Get the catechol-modified chitosan 50mg that embodiment 1 obtains and be dissolved in 1mL PBS (phosphate buffered saline), obtain the catechol-modified chitosan solution; Get the formylation modification that embodiment 2 obtains 50 mg of dextran was dissolved in 1 mL of PBS (phosphate buffered saline) to obtain a dextran solution modified by aldylation; after the two were fully dissolved, 2.5 mg MgO was weighed and added to the dextran In the solution, after rapid mixing, use a 1mL syringe to draw respectively the chitosan solution modified by catechol and the dextran solution modified by aldylation, and then blend with a spiral needle to obtain the multifunctional natural polysaccharide of the present invention. The repair bonding hydrogel is then injected into damaged skin to repair the skin.

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Abstract

A multifunctional natural polysaccharide repairing adhesive hydrogel, a preparation method and its application in the preparation of medicines for treating skin damage belong to the field of material science and technology. The present invention uses natural polysaccharides as raw materials and modifies them with functional groups to enhance their tissue adhesion; and then adds magnesium oxide nanoparticles to the dextran solution modified by aldylation in advance, which can further shorten the gelation time And enhance the antibacterial effect; thus construct a repair adhesive hydrogel with good biocompatibility, tissue adhesion, and effective wound closure. The whole process is simple to operate, the raw materials are readily available and cheap, and the natural polymer functional group modified has good biocompatibility and is non-toxic and harmless to cells. In the invention, the polysaccharide is modified by catechol and aldehyde to enhance the water solubility of the chitosan, reduce the viscosity of the dextran solution, shorten the gelation time of the two-component gel and endow the gel with strong tissue adhesion.

Description

technical field [0001] The invention belongs to the technical field of material science, and in particular relates to a multifunctional natural polysaccharide repairing adhesive hydrogel, a preparation method and its application in the preparation of medicines for treating skin damage. Background technique [0002] As the largest organ of the human body, the skin is the first barrier against external attacks and stimuli. However, in people's daily life, skin cuts and burns are almost inevitable, and open wounds can easily lead to sepsis and even osteomyelitis. Preventing wound infection and promoting rapid wound repair are two major challenges in the field of trauma therapy. Therefore, it is necessary to develop a skin repair adhesive that can effectively close wounds and prevent infection. [0003] Hydrogel is a kind of bulk-phase cross-linked hydrophilic polymer with high water content. Through rational design, functional groups can be inserted into the gel network struct...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08L5/02C08K3/22C08B37/02C08B37/08A61K9/06A61K47/36A61P17/02A61P31/04A61K33/08
CPCA61K9/06A61K33/08A61K47/36A61P17/02A61P31/04C08B37/0021C08B37/003C08J3/075C08J2305/02C08J2305/08C08J2405/02C08J2405/08C08K2003/222C08K2201/011
Inventor 张俊虎唐晓铎李道伟孙漪涵杨柏
Owner JILIN UNIV
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