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Preparation method of betulin-based antibacterial dental composite resin

A technology of composite resin and betulin, applied in dental preparations, dentistry, dental prosthesis, etc., can solve the problems of poor aesthetics and fluidity, poor patient comfort, repair failure, etc., and achieve simple modification methods and excellent mechanical properties Unaffected, well-blended effects

Active Publication Date: 2021-02-02
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1826, French scientists first applied silver amalgam to the treatment of dental caries. However, the traditional silver amalgam not only has poor aesthetics and fluidity, but also has poor comfort for patients after surgery. The subsequent resin-based composite materials can rely on Excellent performance effectively overcomes these shortcomings and occupies a dominant position in dental restoration materials
However, resin-based composites have the problem of secondary caries, which is due to the fact that the resin is prone to polymerization shrinkage during the photocuring process, thereby creating a gap between the dentin and the resin, resulting in microleakage, and at the same time the adhesion of bacterial biofilms, eventually lead to repair failure

Method used

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  • Preparation method of betulin-based antibacterial dental composite resin
  • Preparation method of betulin-based antibacterial dental composite resin
  • Preparation method of betulin-based antibacterial dental composite resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of betulin-based antibacterial dental composite resin: (1) weigh 4.2 g betulin and 0.8 g 4-dimethylaminopyridine in a 500 mL round bottom flask with an analytical balance, add 70 mL dichloromethane for Dissolve and mix until homogeneous at room temperature with a magnetic stirrer.

[0024] (2) Add 18.0 mL of dichloromethane into the constant pressure funnel, measure 1.5 mL of methacrylic anhydride, mix it well, drop it into the round bottom flask in step (1) at room temperature, and react for 24 h , to obtain the crude product.

[0025] (3) Carry out post-processing after the reaction is completed, move the product in step (2) to a separatory funnel, add a mass fraction of 5% sodium hydroxide solution and deionized water to wash 3 times. Finally, add anhydrous magnesium sulfate to dry, obtain a light yellow liquid after suction filtration, and add the liquid to chromatography silica gel according to the mass ratio of betulin monomer to silica gel i...

Embodiment 2

[0030] A preparation method of betulin-based antibacterial dental composite resin:

[0031] (1) Weigh 4.2 g of betulin and 2.4 g of 4-dimethylaminopyridine into a 1000 mL round bottom flask with an analytical balance, add 210 mL of dichloromethane to dissolve, and mix with a magnetic stirrer at room temperature until uniform.

[0032] (2) Add 54.0 mL of dichloromethane into the constant pressure funnel, measure 4.5 mL of methacrylic anhydride, mix well, add dropwise to the round bottom flask in step (1) at room temperature, and react for 24 h , to obtain the crude product.

[0033](3) Carry out post-processing after the reaction is completed, move the product in step (2) to a separatory funnel, add a mass fraction of 5% sodium hydroxide solution and deionized water to wash 3 times. Finally, add anhydrous magnesium sulfate to dry, obtain a light yellow liquid after suction filtration, and add the liquid to chromatography silica gel according to the mass ratio of betulin monome...

Embodiment 3

[0038] A preparation method of betulin-based antibacterial dental composite resin:

[0039] (1) Weigh 4.2 g of betulin and 2.4 g of 4-dimethylaminopyridine into a 1000 mL round bottom flask with an analytical balance, add 210 mL of dichloromethane to dissolve, and mix with a magnetic stirrer at room temperature until uniform.

[0040] (2) Add 54.0 mL of dichloromethane into the constant pressure funnel, measure 4.5 mL of methacrylic anhydride, mix well, add dropwise to the round bottom flask in step (1) at room temperature, and react for 24 h , to obtain the crude product.

[0041] (3) Carry out post-processing after the reaction is completed, move the product in step (2) to a separatory funnel, add a mass fraction of 5% sodium hydroxide solution and deionized water to wash 3 times. Finally, add anhydrous magnesium sulfate to dry, obtain a light yellow liquid after suction filtration, and add the liquid to chromatography silica gel according to the mass ratio of betulin monom...

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Abstract

The invention relates to a preparation method of betulin-based antibacterial dental composite resin. The preparation method comprises the following steps that (1) monosubstituted and disubstituted methacrylate betulin derivatives are prepared; and (2) the prepared betulin derivative are added into a traditional resin matrix, uniform mixing is carried out through a double-core dispersion machine toobtain uncured resin paste, and finally curing is carried out through visible light to obtain the dental restoration resin. The preparation method of the betulin-based antibacterial dental compositeresin is simple and convenient, and the betulin-based antibacterial dental composite resin has polymerization capacity. Compared with a traditional resin matrix, the composite resin prepared from an antibacterial organic monomer has the advantages that the mechanical property is not influenced, and meanwhile, obvious biocompatibility and antibacterial activity are shown.

Description

technical field [0001] The invention belongs to the field of preparation of dental restorative materials, and in particular relates to a preparation method of an antibacterial organic monomer based on betulin and its derivatives for dental composite resin. Background technique [0002] Dental caries, commonly known as tooth decay, is a chronic disease caused by bacteria and microorganisms in the oral cavity decomposing food residues to produce acidic substances that corrode healthy teeth. The essence is a process mediated by biofilm and jointly driven by sugar. The formation process of dental caries mainly includes the demineralization of inorganic matter and the decomposition of organic matter. Pathologically, it is manifested by the gradual change of tooth color visible to the naked eye to the progressive lesion of tooth hard tissue. According to the analysis of archaeologists, the appearance of dental caries can be traced back to 12,000 to 3,000 BC. Human beings gradually...

Claims

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Application Information

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IPC IPC(8): A61K6/80A61K6/69A61K6/884
CPCA61K6/69A61K6/80A61K6/887C07J63/008
Inventor 王瑞莉张璐斯朱美芳马志远
Owner DONGHUA UNIV
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