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Surgical suture with antibacterial and shape memory functions and preparation method thereof

A technique of surgical suturing and memory, which is applied in the fields of surgery, pharmaceutical formulations, rayon manufacturing, etc., can solve the problems of poor bacterial inhibition at the wound, mechanical traction necrosis of the wound, unfavorable wound recovery, etc., so as to avoid mechanical damage of the wound. Effects of stretch necrosis, shortened operation time, excellent shape memory function and mechanical properties

Inactive Publication Date: 2021-02-12
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are still some problems with the currently used surgical sutures. For example, the process of gathering the surgical sutures after the operation (especially the operation with deep organs and narrow surgical field of view) is easy to cause mechanical traction necrosis of the wound and increase wound infection. chance of
In addition, for wounds that are susceptible to infection and difficult to care for postoperatively, there is still a high risk of infection after most of the existing surgical sutures are used, which is not conducive to wound healing
In addition, due to the abuse of antibiotics, a large number of drug-resistant bacteria have been produced, resulting in many existing surgical sutures having poor inhibitory effect on wound bacteria, which is not conducive to wound recovery

Method used

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  • Surgical suture with antibacterial and shape memory functions and preparation method thereof
  • Surgical suture with antibacterial and shape memory functions and preparation method thereof
  • Surgical suture with antibacterial and shape memory functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, the synthesis of shape memory polyurethane SMPU of the present invention

[0056] according to figure 1 According to the route shown, the shape-memory polyurethane SMPU of the present invention is obtained. Specific steps are as follows:

[0057] Add hydroxyl-terminated polycaprolactone (OH-PCL-OH, molecular weight 4000) into the reaction flask, vacuumize after dehydration at 85°C, protect with argon, and then add diphenylmethane diphenylmethane after dehydration at 85°C Isocyanate (MDI), stirred and reacted at 85°C for 2 hours, then added butanediol (BDO), quickly poured the system into a preheated polytetrafluoroethylene mold, and cured in an oven at 80°C for 24 hours, That is, the shape-memory polyurethane SMPU of the present invention is obtained.

[0058] The molar ratio of the above OH-PCL-OH, MDI, BDO is 1:12.2:41.3.

Embodiment 2

[0059] Example 2, the preparation of the shape memory surgical suture SP-1 with antibacterial properties of the present invention

[0060] The shape-memory polyurethane SMPU prepared in Example 1 was added to dimethylacetamide (DMAc), stirred and dissolved to obtain a uniform SMPU solution with an SMPU concentration of 25% mg / mL, and 40 mL of spinning solution.

[0061] The spinning solution was wet spun by a wet spinning device at 25° C., and coagulated in a 40 L coagulation bath (aqueous solution with a PHMB concentration of 20% mg / mL) at 25° C. to obtain spun fibers. The above wet spinning device consisted of a 20 mL syringe and a needle (inner diameter 0.51 mm) driven by a pump, and the spinning solution flow rate was 2.00 mm / min.

[0062] The obtained spun fibers are passed through stretching rollers (the stretching temperature is 25° C.), drying rollers, and finally collected on a rotating mandrel to obtain the antibacterial shape-memory surgical suture SP-1 of the prese...

Embodiment 3

[0063] Example 3, the preparation of the shape memory surgical suture SP-2 with antibacterial properties of the present invention

[0064] The concentration of PHMB in the coagulation bath in Example 2 was modified to 30% mg / mL, and the rest of the raw materials and preparation process were the same as in Example 2 to obtain the antibacterial shape memory surgical suture SP-2 of the present invention.

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PUM

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Abstract

The invention relates to a surgical suture with antibacterial and shape memory functions and a preparation method thereof. The structure of the shape memory polyurethane is shown as a formula I in thespecification. The invention also provides a shape memory surgical suture with antibacterial property, which is prepared from the shape memory polyurethane and an antibacterial drug as raw materialsthrough a spinning process. The surgical suture line is good in biocompatibility, has an excellent shape memory function, can effectively avoid mechanical traction necrosis of a wound in the process of folding the surgical suture line after an operation (especially an operation of deep organs and a narrow operation visual field) is completed, and reduces the wound infection risk; meanwhile, the operation difficulty can be reduced, and the operation time is shortened. Besides, the surgical suture provided by the invention has an obvious inhibition effect on gram-negative bacteria and gram-positive bacteria, can significantly reduce the infection risk of a surgical site and significantly improve the healing ability of a wound after suture, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a surgical suture with antibacterial and shape memory functions and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suturing, hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. The former has the characteristics of high tensile strength, easy disinfection and sterilization, and low tissue reaction, but it cannot be degraded in the body, so it needs to be removed after suturing, which is easy to cause secondary pain, infection, and scars; the latter can be degraded in the body. Soluble products are absorbed by the body and gradually excreted out of the body, thereby reducing the suffering of patients. The ideal absorbable suture material in clinical application should m...

Claims

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Application Information

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IPC IPC(8): C08G18/66C08G18/42C08G18/32D01F6/94D01F1/10A61L17/00A61L17/10
CPCC08G18/664C08G18/4277C08G18/3206D01F6/94D01F1/103A61L17/10A61L17/00A61L17/005C08G2280/00A61L2400/16A61L2300/404A61L2300/216A61L2300/208C08L75/06
Inventor 田猛谭淋周文铖
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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