Magnesium-alloy thermotherapy nano robot and preparation method therefor

A nano-robot, magnesium alloy technology, applied in the nano field, can solve the problems of local inflammatory response, unstable production process, difficult to control degradation time, etc., to achieve the effect of relieving inflammatory response, stable production process and suitable for industrialization

Pending Publication Date: 2021-02-23
湖南早晨纳米机器人有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, most of the reported methods for preparing magnetic magnesium alloy nanorobots are still in the experimental stage, and there are problems such as unstable production process, difficult to control the degradation time, and local inflammatory reactions caused by the degradation process.

Method used

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  • Magnesium-alloy thermotherapy nano robot and preparation method therefor

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preparation example Construction

[0022] The invention provides a method for preparing a magnesium alloy hyperthermia nanorobot, comprising the following steps:

[0023] a) performing solid solution treatment on the magnetic magnesium alloy to obtain a magnetic magnesium alloy melt;

[0024] b) adding the magnetic magnesium alloy melt dropwise into a cold bath under stirring conditions to obtain magnetic magnesium alloy nanoparticles;

[0025] c) mixing the magnetic magnesium alloy nanoparticles and anti-inflammatory drugs in a solvent, centrifuging, and discarding the supernatant to obtain a magnesium alloy nanorobot.

[0026] In the preparation method provided by the present invention, the magnetic magnesium alloy is firstly subjected to solution treatment. Wherein, the chemical composition of the magnetic magnesium alloy preferably includes Nd, Zn, Zr, Fe, Si, Mn and Mg, more preferably includes 4wt% of Nd, 16wt% of Zn, 14-19wt% of Zr, 1wt% of Fe , 0.3wt% of Si, 1wt% of Mn and 55-61wt% of Mg. In an embod...

Embodiment 1

[0036] Preparation of Magnetic Magnesium Alloy Nanoparticles:

[0037] 1) The magnetic magnesium alloy is subjected to solution treatment at 750° C. for 7.5 hours to obtain a magnetic magnesium alloy melt. Wherein, the chemical composition of the magnetic magnesium alloy is: Nd 4wt%, Zn 16wt%, Zr 14-19%, Fe 1wt%, Si 0.3%, Mn 1wt%, and the balance of Mg.

[0038] 2) Add the magnetic magnesium alloy melt dropwise into a -72°C dry ice ethanol bath under stirring conditions. During the dropping process, the dropping rate is controlled at 1-5mL / min, the dropping time is controlled at 10min, and the stirring rate is Control it at 30-50r / min, and control the stirring temperature at 0-30°C.

[0039] 3) After the magnetic magnesium alloy melt has been dripped and added, the magnetic magnesium alloy nanoparticles formed in the ice ethanol bath are collected by centrifugation. The equipment used is an ultracentrifuge from Sigma, Germany, with a centrifugal speed of 9000r / min. Centrifug...

Embodiment 2

[0044] Preparation of magnesium alloy hyperthermia nanorobots:

[0045] 1) Drying and disinfection: the magnetic magnesium alloy nanoparticles with a particle size of 200-500nm prepared in Example 1 were placed in a vacuum environment below 50Pa for drying treatment, and then "ultraviolet-ozone" surface disinfection treatment was performed.

[0046] 2) Drug loading: Add 10 mg of paclitaxel to 50 mL of acetone and ultrasonically dissolve it completely, place it in a centrifuge tube, add 5 mg of the magnetic magnesium alloy nanoparticles treated in step 1), and place it in an ultracentrifuge (Sigma, Germany) at 9000r / min Centrifuge for 120 min, discard the supernatant, and place the centrifuge tube in a vacuum drying oven at 80° C. to dry to constant weight (about 70 min) to obtain a magnesium alloy hyperthermia nanorobot.

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Abstract

The invention belongs to the field of nano technologies and particularly relates to a magnesium-alloy thermotherapy nano robot and a preparation method therefor. The preparation method provided by theinvention comprises the following steps: a) subjecting magnetic magnesium alloy to solid solution treatment, so as to obtain magnetic magnesium alloy melt; b) dropwise adding the magnetic magnesium alloy melt into a cold bath with stirring, so as to obtain magnetic magnesium alloy nanoparticles; and c) mixing the magnetic magnesium alloy nanoparticles with an inflammation diminishing medicine ina solvent, carrying out centrifugation, and discarding supernatant, thereby obtaining the magnesium-alloy nano robot. The preparation method provided by the invention is stable in production process and is applicable to industrialization; and the magnesium-alloy thermotherapy nano robot prepared by employing the method has good magnetic properties, is controllable in degradation time and cannot cause local inflammatory reactions during degradation.

Description

technical field [0001] The invention belongs to the field of nanotechnology, and in particular relates to a magnesium alloy hyperthermia nanorobot and a preparation method thereof. Background technique [0002] Nano-robots refer to small-scale robots at the nanometer level, which have very important potential applications in fields such as biomedicine and environmental protection, such as minimally invasive surgery, targeted therapy, cell manipulation, heavy metal detection, pollutant degradation, etc. , so it has been widely concerned by researchers at home and abroad, and has developed rapidly in recent years. [0003] The working environment of nanorobots is located in an environment with a very low Reynolds coefficient. Objects can be regarded as moving in a very viscous, tiny and slow environment. Viscous forces dominate and inertial forces are negligible. Under such conditions, if you want to drive the nano-robot, you must continuously provide power for it. However, ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K45/06A61K9/00A61L31/02A61L31/14A61L31/16A61P29/00A61P35/00B22F1/00B22F9/08B82Y40/00B82Y25/00B82Y5/00A61K31/337A61K31/436A61K33/36
CPCB22F1/0007A61K41/0052A61L31/022A61L31/16A61L31/148B22F9/08B82Y40/00A61K9/0009A61K45/06A61P35/00A61P29/00B82Y25/00B82Y5/00B22F2009/0804A61K31/337A61K31/436A61K33/36A61L2300/604A61L2300/41A61L2300/416
Inventor 张伯伦杨志
Owner 湖南早晨纳米机器人有限公司
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