Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

44 results about "Localised inflammation" patented technology

Application of gene modified mesenchymal stem cell in pulmonary fibrosis treatment

Relating to the fields of biotechnologies and gene therapy, the invention provides application of a gene modified mesenchymal stem cell in pulmonary fibrosis treatment. The gene modified mesenchymal stem cells are obtained through: in-vitro isolated culture and amplification of a mesenchymal stem cell (MSC) deriving from bone marrow and an umbilical cord, and recombinant adenovirus Ad-HGF mediated in-vitro modification of the MSC by a hepatocyte growth factor (HGF). By transplanting the gene modified MSC to a C57 mouse to intervene in radiation induced lung injury and fibrosis, exudation of a plurality proteins including albumin, IgM and the like from an alveolar space can be reduced, local inflammatory responses of the lung can be alleviated, and expression of TNF-alpha, soluble ICAM-1 and multiple factors is inhibited, expression of the profibrotic factor TGF-beta, the collagen gene col1 alpha 1 and col 3 alpha 1 can be inhibited, and pulmonary tissue collagen fiber deposition is reduced. The expression results of endogenous HGF and its receptor cmet show that endogenous HGF expression can be induced and endogenous MSC can home to injured parts. Therefore, the employment of HGF modified MSC in treatment of lung injury and fibrosis brought by various pathogenic causes is of great significance.
Owner:INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA

Composition with methylprednisolone palmitate as active component for treating local inflammation

The invention relates to a drug composition for treating local inflammation, which uses methylprednisolone palmitate as an active composition. The drug composition consists of the methylprednisolone palmitate as the active composition and an inactive composition suitable for local injection, and is used for treating local inflammation of people or mammal through local injection.
Owner:TIANJIN JINYAO GRP

Traditional Chinese medicine for eliminating pain and preparation method of traditional Chinese medicine

The invention relates to traditional Chinese medicine for eliminating pain and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for eliminating pain is prepared from such raw materials as musk, safflower carthamus, panax notoginseng, dragon's blood, incised notopterygium, ligusticum wallichii, asarum sieboldii, peach kernel, radix angelicae, cassia twig and the like by independently soaking, steaming, fermenting and distilling in groups and mixing. The traditional Chinese medicine disclosed by the invention has beneficial effects that the traditional Chinese medicine for eliminating pain is prepared from natural Chinese herbal medicines through a fermentation process; the traditional Chinese medicine, which can be smeared on or sprayed to an affected part, can rapidly permeate skin so as to accelerate tissue repair, relieve capillary dilation, cell edema, soft tissue injury, local inflammation and like problems, to effectively improve local edema, pain or dermal inflammation, provide nutrition to tissue cell regeneration or soft tissue recovery, offer effective help to bone joint lubrication and cell reconstruction, significantly shorten recovery time in patients with bone and joint diseases and relieve the feeling of pain.
Owner:顾璟豪

Glycolipid Mixture with Anti-Inflammatory Activity Obtained from Oscillatoria Planktothrix

It was observed that a highly purified preparation of polar glycolipids extracted from cells of the cyanobacterium Oscillatoria Planktothrix is characterized by the presence of at least one species of high molecular weight glycolipid comprising one or more units of rhamnose. In such mixture, having a level of nucleic acid contamination lower than (or equal to) 3%, an inhibitory activity toward ATP synthase (ATP-SX) was identified which is capable of decreasing the level of extracellular ATP and thereby the extent of the inflammatory response. The glycolipid mixture is especially useful in inflammation induced by ischemic stimuli, cancer or autoimmune diseases (such as multiple sclerosis, inflammatory bowel disease (Crohn's disease, ulcerative colitis), psoriasis, rheumatoid arthritis, diabetes, autoimmune thyroiditis, systemic lupus erythematosus), in addition to systemic inflammatory states such as systemic inflammatory syndrome (SIRS), sepsis, vasculitis, or in localized inflammatory states, such as neurodegenerative diseases or asthma.
Owner:BLUEGREEN BIOTECH

Cyclopropyl pregnene compound and application thereof

The invention discloses a cyclopropyl pregnene compound and application thereof, and discloses a novel adrenocortical hormone compound shown in a formula (I), a medicine composition containing the compound shown in the formula (I) as an active component and one or more pharmaceutic adjuvants, and application of the compound shown in the formula (I) or physiologically acceptable salt or solvate thereof as a medicine for treating of the diseases of mammal especially human, especially local inflammation.
Owner:TIANJIN JINYAO GRP

Essence lotion composition with moisturizing and soothing effects and preparation method and application thereof

ActiveCN113712894ARelieves symptoms of redness and feverConditioning keratinocyte stromaCosmetic preparationsAntipyreticPreservativeCodium fragile extract
The invention discloses an essence lotion composition with moisturizing and soothing effects and a preparation method thereof. Based on the total weight of 100 parts of the composition, the essence lotion composition contains the following raw material components in parts by weight: 1 to 30 parts of moisturizing and smoothing functional components, 1 to 30 parts of an emollient, 0.1 to 25 parts of an emulsifier, 0.5 to 28 parts of a filler, 0.2 to 9 parts of a thickener, 0.2 to 5 parts of a preservative, 0.01 to 4 parts of a pH regulator, 0.001 to 1 part of a daily essence and the balance deionized water. The moisturizing and soothing functional components contain panthenol, inositol, a lactococcus ferment lysate and a codium fragile extract. According to the cosmetic composition with the moisturizing and soothing effects of the invention, all the components are compounded, so that the cosmetic composition can supplement water, moisturize, repair skin barriers, relieve local inflammations of skin, help the skin to lock moisture, increase skin elasticity and keep the skin light and moist all the time, and the cosmetic composition is free of side effects and suitable for most people to use.
Owner:湖北省麦诗特生物科技有限公司

Non-woven fabric and production process thereof

The invention discloses a non-woven fabric, a production process of the non-woven fabric and baby diapers made of the non-woven fabric, and belongs to the technical field of light industry. The surface of the non-woven fabric is attached with sodium bicarbonates and shikonin. The preparation method includes the following steps that aqueous solutions are modulated, and the aqueous solutions are prepared according to the mass ratio of water, the sodium bicarbonates and the shikonin of (90-110) : (3-5) : 1; atomization and spraying are conducted, and the modulated aqueous solutions are atomized and sprayed onto carded and formed screen cloth; and heat seal, evaporation and forming are conducted. The non-woven fabric can dissolve effective ingredients of inhibiting fungi and eliminating localskin inflammation after being treated with water, thus improving the safety and comfort of the non-woven fabric for baby skin. The sodium bicarbonates and the shikonin can produce a synergistic effect, on one hand, the uric acid in the urine of babies can be neutralized to make the urine be weakly alkaline and avoid the irritation to baby skin, and on the other hand, under the weakly alkaline condition, the shikonin can be dissolved and plays an antibacterial and antiphlogistic role.
Owner:重庆市爱佳众想卫生用品有限公司 +1

Composition helpful for dissolving blood vessel plaque and preparation method thereof

The invention discloses a composition helpful for dissolving vascular plaques and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the preparation, radix rehmanniae, cornus officinalis, Chinese yam, poria cocos, rhizoma alismatis and cortex moutan are used for nourishing kidney and purging turbidity, Chinese angelica, peach kernel, ligusticum wallichii, pseudo-ginseng, ground beeltle and leech are used for promoting blood circulation and removing blood stasis, centipede, caulis spatholobi and honeysuckle stem are used for dredging collaterals and smoothing channels, spina gleditsiae, radix semiaquilegiae and hawthorn are used for eliminating phlegm and diminishing swelling, dandelion and herba violae are used for clearing away heat and toxic materials, sun-dried ginseng is used for tonifying qi and regenerating new energy, the invention provides a preparation method of various preparations, the preparation process of each preparation is simple and easy to operate, and loss of effective components is not caused in the preparation process. The preparation helpful for dissolving vascular plaques has the functions of improving microcirculation, inhibiting local inflammation and promoting vascular endothelial regeneration. The preparation helpful for dissolving the vascular plaque is suitable for various diseases such as neck vascular plaque, lower limb vascular embolism, coronary arteriosclerosis heart disease, cerebrovascular diseases and the like caused by the vascular plaque.
Owner:陈遥

Drainage device, drainage method and drainage device manufacturing method

The invention discloses a novel drainage device which comprises a drainage tube, a clamping balloon connected with the drainage tube, a clamping balloon filler, a communicating tube, a locking device and a support tube movably arranged in the drainage device. And at least one section of drainage tube wall is a flexible tube wall. When the drainage device is in a non-drainage state, the flexible drainage tube body of the drainage channel is good in shape follow-up performance, small in extrusion and expansion degree on tissues around the drainage tube and light in local inflammatory response; when drainage is needed, the support tube moves to the narrow portion of the drainage channel along the inner side of the drainage tube wall, and the drainage process is completed. The invention further discloses a manufacturing method for manufacturing the clamping balloon, the drainage tube, the communicating tube and related structures of the clamping balloon, the drainage tube and the communicating tube, and the manufacturing method comprises the steps that basic pipelines are manufactured firstly, then the basic pipelines are machined and combined, and related accessories are configured. The drainage device also has a reverse conveying function, and particularly plays an important role in food conveying of the upper digestive tract.
Owner:于从军

Carrier for removing inflammatory factors in articular cavity effusion and releasing anti-inflammatory drugs

The invention discloses a carrier for removing inflammatory factors in articular cavity effusion and releasing anti-inflammatory drugs. The carrier comprises a main body structure, the main body structure comprises a spherical outer wrapping layer and a central sphere, the spherical outer wrapping layer is uniformly provided with a plurality of through holes, the central sphere is wrapped in the spherical outer wrapping layer, the spherical outer wrapping layer is formed by a membrane made of phospholipid, the thickness of the spherical outer wrapping layer is 50-100 microns, the plurality of through holes are round through holes, the aperture of the plurality of through holes is 30-50 microns, and the central sphere is made of nano-scale anti-inflammatory drug particles. The carrier for removing the inflammatory factors in the articular cavity effusion and releasing the anti-inflammatory drugs can be metabolized and absorbed by a human body, can effectively remove the inflammatory factors in the articular cavity of the human body, can be used as the carrier to release and slowly release the anti-inflammatory drugs, and finally achieves the purposes of removing the inflammatory factors in the articular cavity and controlling local inflammation so as to controlthe illness state, and side effects can be avoided.
Owner:南通市中医院

A kind of plaster for treating rheumatic bone disease and preparation method thereof

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a plaster for treating rheumatic bone disease and a preparation method thereof, which is prepared from the following raw materials in parts by weight: 3 parts of angelica, 3 parts of Chuanxiong, 3 parts of frankincense, 3 parts of myrrh, 2 parts of cinnamon sticks, 2 parts of safflower, 2 parts of ground turtle, 2 parts of Clematis, 2 parts of sumac, 3 parts of Achyranthes bidentata, 2 parts of Asarum, 2 parts of Zhicaowu, 2 parts of Zhichuanwu 2 parts, 2 parts of southern star, 2 parts of pinellia, 3 parts of rhubarb, 3 parts of bletilla striata, 2 parts of zhebei, 2 parts of angelica dahurica, 2 parts of nuxychee, 3 parts of turmeric, 10 parts of borneol, 500 parts of sesame oil, the present invention A variety of Chinese herbal medicines are used in combination and comprehensive treatment. The active ingredients of the medicine penetrate into the lesion through the skin, improve the blood circulation of the lesion, promote the subsidence of local inflammation and edema, relieve muscle tension and spasm, and quickly relieve symptoms. It is suitable for various Rheumatic bone diseases such as rheumatism, rheumatoid arthritis, degenerative arthritis, etc. The medicine components are cheap and suitable for industrial production.
Owner:麻礽聪

Biological-friendly myocardial dressing as well as preparation method and application thereof

The invention relates to a bio-friendly myocardial dressing as well as a preparation method and application thereof, and belongs to the field of biomedical materials. In order to solve the problems that an existing myocardial patch is complex in raw material, a cross-linking agent has cytotoxicity, and postoperative safety is easily affected, the invention provides a biological friendly myocardial dressing which comprises fat acellular matrix hydrogel and / or a myocardial patch, the fat acellular matrix hydrogel takes fat acellular matrix as a main raw material, and the cross-linking agent has cytotoxicity. The myocardial local compliance can be improved; a plant-derived polyphenol cross-linking agent and fat acellular matrix hydrogel are subjected to cross-linking and freeze-drying to prepare the myocardial patch, and the myocardial patch can support diseased myocardium. The two can be used independently and can also be used in a combined manner, and the combined use can give consideration to the effects of mechanical support and myocardial local compliance improvement. The composition of the raw materials is safe and reliable, immunogenicity and local inflammatory response are reduced to the maximum extent, and good biocompatibility is achieved.
Owner:HARBIN MEDICAL UNIVERSITY

Chicken embryo peptide as well as preparation method and application thereof in preparation of anti-inflammation, acne removal and black hair generation products

The invention relates to the field of biotechnology and particularly relates to a chicken embryo peptide as well as a preparation method and application thereof. The chicken embryo peptide provided by the invention comprises chicken embryo peptide and free amino acid, wherein the molecular weight of the chicken embryo peptide is less than 50kDa. The chicken embryo peptide provided by the invention can realize the anti-inflammation, acne removal and black hair generation functions; and survey result indicates that the chicken embryo peptide provided by the invention has a good effect on local inflammation and detumescence of human body epidermis and particularly realizes a perfect curative effect on mosquito bites. Moreover, the chicken embryo peptide provided by the invention can realize a good effect on the acnes on human faces and also can promote the regeneration of black hair. The preparation method of the chicken embryo peptide provided by the invention is easy and convenient to operate; and through homogenization, freeze thawing and ultrasonication, the cytomembrane is broken to the greatest extent so that intracellular bioactive peptides are dissolved out well and the extraction efficiency is improved.
Owner:耿威
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products