46 results about "Localised inflammation" patented technology

Relating to the fields of biotechnologies and gene therapy, the invention provides application of a gene modified mesenchymal stem cell in pulmonary fibrosis treatment. The gene modified mesenchymal stem cells are obtained through: in-vitro isolated culture and amplification of a mesenchymal stem cell (MSC) deriving from bone marrow and an umbilical cord, and recombinant adenovirus Ad-HGF mediated in-vitro modification of the MSC by a hepatocyte growth factor (HGF). By transplanting the gene modified MSC to a C57 mouse to intervene in radiation induced lung injury and fibrosis, exudation of a plurality proteins including albumin, IgM and the like from an alveolar space can be reduced, local inflammatory responses of the lung can be alleviated, and expression of TNF-alpha, soluble ICAM-1 and multiple factors is inhibited, expression of the profibrotic factor TGF-beta, the collagen gene col1 alpha 1 and col 3 alpha 1 can be inhibited, and pulmonary tissue collagen fiber deposition is reduced. The expression results of endogenous HGF and its receptor cmet show that endogenous HGF expression can be induced and endogenous MSC can home to injured parts. Therefore, the employment of HGF modified MSC in treatment of lung injury and fibrosis brought by various pathogenic causes is of great significance.

Compositions containing purified collagen biomaterial derived from tissues, for example, insoluble amnion, soluble amnion, soluble chorion of the human placenta, are provided. The collagen compositions can be used to promote wound healing, promote tissue regeneration, prevent or reduce scarring, reduce local inflammation, minimize tissue rejection, promote graft integration. Methods for using the collagen composition as a biomaterial implant for dermal filling, skin grafting, and hair transplantation are also provided.

The invention relates to a drug composition for treating local inflammation, which uses methylprednisolone palmitate as an active composition. The drug composition consists of the methylprednisolone palmitate as the active composition and an inactive composition suitable for local injection, and is used for treating local inflammation of people or mammal through local injection.

The invention relates to traditional Chinese medicine for eliminating pain and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for eliminating pain is prepared from such raw materials as musk, safflower carthamus, panax notoginseng, dragon's blood, incised notopterygium, ligusticum wallichii, asarum sieboldii, peach kernel, radix angelicae, cassia twig and the like by independently soaking, steaming, fermenting and distilling in groups and mixing. The traditional Chinese medicine disclosed by the invention has beneficial effects that the traditional Chinese medicine for eliminating pain is prepared from natural Chinese herbal medicines through a fermentation process; the traditional Chinese medicine, which can be smeared on or sprayed to an affected part, can rapidly permeate skin so as to accelerate tissue repair, relieve capillary dilation, cell edema, soft tissue injury, local inflammation and like problems, to effectively improve local edema, pain or dermal inflammation, provide nutrition to tissue cell regeneration or soft tissue recovery, offer effective help to bone joint lubrication and cell reconstruction, significantly shorten recovery time in patients with bone and joint diseases and relieve the feeling of pain.

The present invention is directed to the discovery that allogenic or syngenic adjuvant stimulation can cause local inflammation which increases the antigen presentation capability of cells in the vicinity of adjuvant stimulation. By discovering this phenomenon, the present invention provides a novel method for augmenting the immunogencity of an antigen by conjointly administering an allogenic or syngenic MHC molecule (as a universal adjuvant) to trigger a local inflammatory reaction to enhance antigen presentation at the site of delivery.

It was observed that a highly purified preparation of polar glycolipids extracted from cells of the cyanobacterium Oscillatoria Planktothrix is characterized by the presence of at least one species of high molecular weight glycolipid comprising one or more units of rhamnose. In such mixture, having a level of nucleic acid contamination lower than (or equal to) 3%, an inhibitory activity toward ATP synthase (ATP-SX) was identified which is capable of decreasing the level of extracellular ATP and thereby the extent of the inflammatory response. The glycolipid mixture is especially useful in inflammation induced by ischemic stimuli, cancer or autoimmune diseases (such as multiple sclerosis, inflammatory bowel disease (Crohn's disease, ulcerative colitis), psoriasis, rheumatoid arthritis, diabetes, autoimmune thyroiditis, systemic lupus erythematosus), in addition to systemic inflammatory states such as systemic inflammatory syndrome (SIRS), sepsis, vasculitis, or in localized inflammatory states, such as neurodegenerative diseases or asthma.

A disclosed Chinese herbal medicine sterilization tooth powder is prepared from the following raw materials in parts by weight: 5-10 parts of flos sophorae immaturus, 5-12 parts of herba cynomorii, 8-15 parts of juncus setchuensis, 18-26 parts of gleditsiae sinensis fructus, 8-15 parts of elemi, 8-12 parts of polygonum suffultum, 8-12 parts of phoenix dactylifera, 6-12 parts of pistacia vera L., and 4-10 parts of panax notoginseng. Compared with conventional tooth powders, the traditional Chinese medicine sterilization tooth powder is capable of effectively eliminating periodontium local inflammation, alleviating and eliminating gingival swelling ache and accompanied symptoms, and reaches the effects of reinforcing the healthy qi and eliminating the pathogenic factors, clearing heat and expelling toxin, expelling pus and dispersing swelling, and stopping bleeding and reinforcing teeth. The multiple medicines cooperate for downbearing fire, detoxifying and dispersing swelling, cooling blood and stopping bleeding, and resolving stasis and freeing the collateral vessels, and the traditional Chinese medicine sterilization tooth powder has the effect of simultaneous treating principal and subordinate symptoms of periodontitis.

The invention relates to a traditional Chinese medicine plaster for curing cold and cough, abdominal pain and diarrhea, and discloses a traditional Chinese medicine sticking plaster for curing cold and cough, abdominal pain and diarrhea of children. The traditional Chinese medicine sticking plaster consists of the following components in parts by weight: 5 to 60 parts of fructus psoraleae, 4 to 40parts of semen brassicae, 4 to 60 parts of corydalis tuber, 3 to 40 parts of asarum, 5 to 60 parts of Pinellia ternate, 3 to 60 parts of cortex cinnamomi, 4 to 40 parts of Syzygium aromaticum, 4 to 40 parts of radix angelicae, 4 to 60 parts of pollen, 3 to 40 parts of Euphorbia kansui, 5 to 60 parts of rhizoma zingiberis, 3 to 40 parts of raw ephedra and 5 to 40 parts of gallnut. According to thetraditional Chinese medicine sticking plaster, acupuncture points are stimulated by the medicine properties of the medicine, the traditional Chinese medicine sticking plaster can regulate the Qi of main and collateral channels, and the purposes of reaching affected area by Qi, improving local blood circulation and quickening local inflammation resolution are reached.

A disclosed traditional Chinese medicine sterilization tooth powder is prepared from the following raw materials in parts by weight: 5-10 parts of radix salviae miltiorrhizae, 5-12 parts of radix angelicae pubescentis, 8-15 parts ofjuncus setchuensis , 18-26 parts of gleditsiae sinensis fructus, 8-15 parts of elemi, 8-12 parts of polygonum suffultum, 8-12 parts of phoenix dactylifera, 6-12 parts of pistacia vera L., and 4-10 parts of Chinese soapberry fruit. Compared with conventional tooth powders, the traditional Chinese medicine sterilization tooth powder is capable of effectively eliminating periodontium local inflammation, alleviating and eliminating gingival swelling ache and accompanied symptoms, and reaches the effects of reinforcing the healthy qi and eliminating the pathogenic factors, clearing heat and expelling toxin, expelling pus and dispersing swelling, and stopping bleeding and reinforcing teeth. The multiple medicines cooperate for downbearing fire, detoxifying and dispersing swelling, cooling blood and stopping bleeding, and resolving stasis and freeing the collateral vessels, and the traditional Chinese medicine sterilization tooth powder has the effect of simultaneous treating principal and subordinate symptoms of periodontitis.

A novel treatment for topical inflammatory conditions such as acne, eczema, shingles, insect bites and hives is provided, consisting of the application of a pharmaceutical cream or ointment which incorporates hydroxypropyl methylcellulose acetate succinate (“HPMCAS”) in a micronized form and which preferably contains one or more thickeners, a bio-adhesive agent and water so that the formulation, when applied, can stick to the area to be treated.

The invention belongs to the field of traditional Chinese medicine, and relates to use of total flavonoids of Houttuynia cordata in preparing a medicine for preventing and treating viral pneumonia. The product yield of a total flavonoid extract extracted from the traditional Chinese medicine Houttuynia cordata is 1.5% or more, the flavonoid content is 75% or more, and main flavonoid components include quercitrin, hyperoside, isoquercitrin, rutin, and the like. The significant therapeutic effect of the total flavonoids of Houttuynia cordata on influenza a virus H1N1-induced mouse viral pneumonia is confirmed by whole animal experiments, the total flavonoids of Houttuynia cordata reduce the capillary permeability of the lung, reduce pulmonary edema, inhibit inflammatory reactions in the whole body and local inflammatory reactions in the lung, thereby reducing acute lung injury. The total flavonoids of Houttuynia cordata can be further used for preparing the medicine for preventing and treating viral pneumonia.

The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.

The invention discloses a hot and sour rice noodle ingredient and a making method thereof. The hot and sour rice noodle ingredient comprises, by weight, 200-300g of streaky pork, 150-200g of black carps, 10-20g of cooking wine, 15-25g of garlic sprouts, 5-15g of fresh ginger, 5-10g of edible salt, 3-5g of wilson cinnamon barks, 5-8g of star anise fruits and 4-6g of fennel fruits. The hot and sourrice noodle ingredient has the advantages of smooth, crispy and tender properties, meat juice overflow, full taste, crispy chewing properties and the like. The excitability of a respiratory center canbe effectively reduced, respiratory movement tends to be quiet, the functions of relieving cough and asthma are achieved, good wetting and physical therapy functions are achieved for a laryngeal partof pharynx, local inflammation healing is facilitated, local itching can be relieved, so that cough reflex is blocked, respiratory tract inflammation and the viscosity of secretions can be diluted, the secretions are easily coughed up, coughing and phlegm removal are facilitated, and nutritional components of the hot and sour rice noodle ingredient are greatly improved.

The invention discloses a cyclopropyl pregnene compound and application thereof, and discloses a novel adrenocortical hormone compound shown in a formula (I), a medicine composition containing the compound shown in the formula (I) as an active component and one or more pharmaceutic adjuvants, and application of the compound shown in the formula (I) or physiologically acceptable salt or solvate thereof as a medicine for treating of the diseases of mammal especially human, especially local inflammation.

The invention discloses an essence lotion composition with moisturizing and soothing effects and a preparation method thereof. Based on the total weight of 100 parts of the composition, the essence lotion composition contains the following raw material components in parts by weight: 1 to 30 parts of moisturizing and smoothing functional components, 1 to 30 parts of an emollient, 0.1 to 25 parts of an emulsifier, 0.5 to 28 parts of a filler, 0.2 to 9 parts of a thickener, 0.2 to 5 parts of a preservative, 0.01 to 4 parts of a pH regulator, 0.001 to 1 part of a daily essence and the balance deionized water. The moisturizing and soothing functional components contain panthenol, inositol, a lactococcus ferment lysate and a codium fragile extract. According to the cosmetic composition with the moisturizing and soothing effects of the invention, all the components are compounded, so that the cosmetic composition can supplement water, moisturize, repair skin barriers, relieve local inflammations of skin, help the skin to lock moisture, increase skin elasticity and keep the skin light and moist all the time, and the cosmetic composition is free of side effects and suitable for most people to use.

The invention relates to application of a cationic polymer in preparation of a medicine for preventing or treating diseases caused by toxins generated by intestinal microorganisms or diseases caused by new coronavirus infection. Toxin released by intestinal microorganisms can be neutralized and cleared by oral administration of cationic polymers, and most of these microbial toxins present anionic acidity. By adopting the application, various intestinal microbial toxins entering blood can be reduced; therefore, systemic inflammation, local inflammation, hepatic failure and liver injury, insulin tolerance, fatty liver disease, lung failure, kidney failure, hepatic encephalopathy, septicemia and inflammatory storm, severe illness and the like caused by novel coronavirus infection are relieved; the traditional Chinese medicine composition can also be used for treating ICU patients, reducing systemic inflammation, recovering organ functions and improving the survival rate, and can also be used for preventing or treating chronic inflammation and various metabolic diseases caused by intestinal bacterial toxins, preventing and treating fatty liver diseases, relieving insulin tolerance, relieving diabetes mellitus and relieving obesity.

The invention discloses a non-woven fabric, a production process of the non-woven fabric and baby diapers made of the non-woven fabric, and belongs to the technical field of light industry. The surface of the non-woven fabric is attached with sodium bicarbonates and shikonin. The preparation method includes the following steps that aqueous solutions are modulated, and the aqueous solutions are prepared according to the mass ratio of water, the sodium bicarbonates and the shikonin of (90-110) : (3-5) : 1; atomization and spraying are conducted, and the modulated aqueous solutions are atomized and sprayed onto carded and formed screen cloth; and heat seal, evaporation and forming are conducted. The non-woven fabric can dissolve effective ingredients of inhibiting fungi and eliminating localskin inflammation after being treated with water, thus improving the safety and comfort of the non-woven fabric for baby skin. The sodium bicarbonates and the shikonin can produce a synergistic effect, on one hand, the uric acid in the urine of babies can be neutralized to make the urine be weakly alkaline and avoid the irritation to baby skin, and on the other hand, under the weakly alkaline condition, the shikonin can be dissolved and plays an antibacterial and antiphlogistic role.

Disclosed are means of treatment of cancer by enhancing efficacy of oncolytic virus ability to eradicate tumors through the destruction / inactivation of cancer endothelial cells through immunological means. In one embodiment of the invention, administration of placental endothelial cells generated antitumor endothelial immune responses are used to sensitize tumors to oncolytic viral entry. In another embodiment, oncolytic viruses are utilized to enhance generation of cancer endothelial specific responses by causing localized inflammation in the tumor endothelium, which enhances efficacy of the tumor endothelial targeting vaccine. In another embodiment, the invention teaches the use of replication deficient oncolytic viruses to deliver proteins to tumor cells in an immunogenic manner such that proteins encoded by the oncolytic viruses induce immunity to tumor endothelial cell antigens.

Disclosed in certain embodiments is a method for treating chronic pain with a hetero-substituted acetanilide compound that modulates the adenosine receptor. Disclosed in certain embodiments is a method for treating neuropathic pain (e.g., acute or chronic) with a hetero-substituted acetanilide compound that modulates the adenosine A3 receptor. Disclosed in certain embodiments is a method for treating inflammation (e.g., local inflammation or systemic inflammation), an inflammatory response, or an inflammatory condition with a hetero-substituted acetanilide compound.

Compounds of the general formula (I) and (II) (including formulae (III) to (V)), wherein X=—CH2—, —O—, —S— n=0-10 Y=—NH—, —NHSO2—, —NHSO—, —NHCO—, —S—, —O—, —CH═CH—R1-R7, equal or different can be hydrogen, alkyl C1-C4, alkenyl C2-C4, cycloalkyl C3-C7, aryl or heteroaryl; may be substituted with one or more alkyl C1-C4, alkoxyl C1-C4, alkylthio C1-C4 or halogens; —NR8R9, where R8 e R9, equal or different, represent hydrogen, alkyl C1-C4, alkenyl C2-C4, cycloalkyl C3-C7, aryl or heteroaryl, may be substituted with one or more C1-C4, alkoxyl C1-C4, alkylthio C1-C4 or halogens; —(CH2)n, —COOR10, with n′=0-4 and R3=hydrogen or alkyl C1-C4, and their addition salts with organic and inorganic acids, or alkaline and alkaline earth metal or ammonium ions, with the exclusion of the compounds having the following formulae ((VI) to (IX)).

Compositions containing purified collagen biomaterial derived from tissues, for example, insoluble amnion, soluble amnion, soluble chorion of the human placenta, are provided. The collagen compositions can be used to promote wound healing, promote tissue regeneration, prevent or reduce scarring, reduce local inflammation, minimize tissue rejection, promote graft integration. Methods for using the collagen composition as a biomaterial implant for dermal filling, skin grafting, and hair transplantation are also provided.

The invention discloses a composition helpful for dissolving vascular plaques and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. According to the preparation, radix rehmanniae, cornus officinalis, Chinese yam, poria cocos, rhizoma alismatis and cortex moutan are used for nourishing kidney and purging turbidity, Chinese angelica, peach kernel, ligusticum wallichii, pseudo-ginseng, ground beeltle and leech are used for promoting blood circulation and removing blood stasis, centipede, caulis spatholobi and honeysuckle stem are used for dredging collaterals and smoothing channels, spina gleditsiae, radix semiaquilegiae and hawthorn are used for eliminating phlegm and diminishing swelling, dandelion and herba violae are used for clearing away heat and toxic materials, sun-dried ginseng is used for tonifying qi and regenerating new energy, the invention provides a preparation method of various preparations, the preparation process of each preparation is simple and easy to operate, and loss of effective components is not caused in the preparation process. The preparation helpful for dissolving vascular plaques has the functions of improving microcirculation, inhibiting local inflammation and promoting vascular endothelial regeneration. The preparation helpful for dissolving the vascular plaque is suitable for various diseases such as neck vascular plaque, lower limb vascular embolism, coronary arteriosclerosis heart disease, cerebrovascular diseases and the like caused by the vascular plaque.

The invention discloses a novel drainage device which comprises a drainage tube, a clamping balloon connected with the drainage tube, a clamping balloon filler, a communicating tube, a locking device and a support tube movably arranged in the drainage device. And at least one section of drainage tube wall is a flexible tube wall. When the drainage device is in a non-drainage state, the flexible drainage tube body of the drainage channel is good in shape follow-up performance, small in extrusion and expansion degree on tissues around the drainage tube and light in local inflammatory response; when drainage is needed, the support tube moves to the narrow portion of the drainage channel along the inner side of the drainage tube wall, and the drainage process is completed. The invention further discloses a manufacturing method for manufacturing the clamping balloon, the drainage tube, the communicating tube and related structures of the clamping balloon, the drainage tube and the communicating tube, and the manufacturing method comprises the steps that basic pipelines are manufactured firstly, then the basic pipelines are machined and combined, and related accessories are configured. The drainage device also has a reverse conveying function, and particularly plays an important role in food conveying of the upper digestive tract.

The invention discloses application of lactic acid and salt thereof. The lactic acid and the salt thereof are applied to preparation of drugs for preventing or treating ethanol-induced gastric mucosal lesion, and the salt is pharmaceutically acceptable salt. The lactic acid can reduce uncontrolled local inflammatory response when gastric mucosa is damaged, and intervene in apoptosis of gastric mucosa cells by down-regulating expression of Bax and Caspase-3 genes; and in addition, the lactic acid can up-regulate the expression of tight junction protein genes such as Occludin, Claudin-1 and Claudin-5 in gastric tissues, and finally, the severity of the ethanol-induced gastric mucosal lesion is remarkably relieved.

The invention discloses a carrier for removing inflammatory factors in articular cavity effusion and releasing anti-inflammatory drugs. The carrier comprises a main body structure, the main body structure comprises a spherical outer wrapping layer and a central sphere, the spherical outer wrapping layer is uniformly provided with a plurality of through holes, the central sphere is wrapped in the spherical outer wrapping layer, the spherical outer wrapping layer is formed by a membrane made of phospholipid, the thickness of the spherical outer wrapping layer is 50-100 microns, the plurality of through holes are round through holes, the aperture of the plurality of through holes is 30-50 microns, and the central sphere is made of nano-scale anti-inflammatory drug particles. The carrier for removing the inflammatory factors in the articular cavity effusion and releasing the anti-inflammatory drugs can be metabolized and absorbed by a human body, can effectively remove the inflammatory factors in the articular cavity of the human body, can be used as the carrier to release and slowly release the anti-inflammatory drugs, and finally achieves the purposes of removing the inflammatory factors in the articular cavity and controlling local inflammation so as to controlthe illness state, and side effects can be avoided.

The invention discloses an acupoint tablet for enhancing acupoint medicine application absorption in medicine magnetic treatment and preparation thereof, and relates to the field of production, development and application of medical health care products. Combined application of acupoints and medicines is generally accepted by common people clinically. The functional characteristics of the acupoints enhance the drug efficacy, and the two are combined to obtain an application effect to the greatest extent; factors such as low absorption efficiency of the medicine in human acupuncture points andlocal inflammatory response in the medicine application process influence clinicians to treat diseases by using an acupuncture point medicine application method; change of the medicine absorption efficiency of acupoint skin is the key of clinical acupoint medicine application treatment, and on the basis of the principle that expansion coefficients of sponge spicules and water-absorbent resin are different after water absorption, the better medicine absorption effect is achieved.

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a plaster for treating rheumatic bone disease and a preparation method thereof, which is prepared from the following raw materials in parts by weight: 3 parts of angelica, 3 parts of Chuanxiong, 3 parts of frankincense, 3 parts of myrrh, 2 parts of cinnamon sticks, 2 parts of safflower, 2 parts of ground turtle, 2 parts of Clematis, 2 parts of sumac, 3 parts of Achyranthes bidentata, 2 parts of Asarum, 2 parts of Zhicaowu, 2 parts of Zhichuanwu 2 parts, 2 parts of southern star, 2 parts of pinellia, 3 parts of rhubarb, 3 parts of bletilla striata, 2 parts of zhebei, 2 parts of angelica dahurica, 2 parts of nuxychee, 3 parts of turmeric, 10 parts of borneol, 500 parts of sesame oil, the present invention A variety of Chinese herbal medicines are used in combination and comprehensive treatment. The active ingredients of the medicine penetrate into the lesion through the skin, improve the blood circulation of the lesion, promote the subsidence of local inflammation and edema, relieve muscle tension and spasm, and quickly relieve symptoms. It is suitable for various Rheumatic bone diseases such as rheumatism, rheumatoid arthritis, degenerative arthritis, etc. The medicine components are cheap and suitable for industrial production.

The invention provides a novel cell culture fluid sponge patch for relieving arthritis pain, which comprises a long adhesive tape and a round gauze, the round gauze is arranged on the long adhesive tape, the round gauze is a hydrolyzed sponge patch, and the hydrolyzed sponge patch contains a mixture of exosome of umbilical cord stem cells and hydrolyzed sponge. According to the method, in the in-vitro culture of the umbilical cord mesenchymal stem cells, a large amount of cell factor protein is secreted in the culture supernatant, the cell culture supernatant is prepared with the function of effectively relieving local inflammatory reaction and the like, and meanwhile, the characteristics of the hydrolyzed sponge are utilized to help puncture of the outer skin layer, so that the umbilical cord mesenchymal stem cells can be effectively cultured. The method is a brand-new method for promoting cell factors in the culture supernatant to smoothly enter the corium layer through the cuticle.

The invention relates to a bio-friendly myocardial dressing as well as a preparation method and application thereof, and belongs to the field of biomedical materials. In order to solve the problems that an existing myocardial patch is complex in raw material, a cross-linking agent has cytotoxicity, and postoperative safety is easily affected, the invention provides a biological friendly myocardial dressing which comprises fat acellular matrix hydrogel and / or a myocardial patch, the fat acellular matrix hydrogel takes fat acellular matrix as a main raw material, and the cross-linking agent has cytotoxicity. The myocardial local compliance can be improved; a plant-derived polyphenol cross-linking agent and fat acellular matrix hydrogel are subjected to cross-linking and freeze-drying to prepare the myocardial patch, and the myocardial patch can support diseased myocardium. The two can be used independently and can also be used in a combined manner, and the combined use can give consideration to the effects of mechanical support and myocardial local compliance improvement. The composition of the raw materials is safe and reliable, immunogenicity and local inflammatory response are reduced to the maximum extent, and good biocompatibility is achieved.