92 results about "Localised inflammation" patented technology

The invention relates to the field of ulcerative colitis, and discloses a multi-parameter monitoring system for evaluating the intestinal barrier function of ulcerative colitis, which is used for realizing the goal of automatically adjusting a treatment scheme according to a monitoring result by constructing a closed-loop feedback treatment system. According to the invention, by designing the nanoprobe of which the surface is modified with a specific binding element and combining with a swallowing capsule endoscopy, real-time imaging and molecular level dynamic tracking of the intestinal barrier are realized, genetically engineered bacteria are constructed to quantify intestinal permeability abnormality and local inflammation level, and an intestinal barrier function damage score and a disease progress prediction result are output; individual monitoring is achieved through transfer learning, ultrasonic elastography, optical coherence tomography, wearable equipment for measuring intestinal electric field impedance spectroscopy and other technologies are adopted, an intestinal wall mechanics-electrophysiology composite parameter set is obtained, and the evaluation accuracy is improved.

The invention discloses a PRP (platelet-rich plasma) stem cell exosome chitosan composition as well as a preparation method and application thereof. The PRP stem cell exosome chitosan composition comprises the following components: activated platelet-rich plasma, stem cell exosome and chitosan. The preparation method of the composite gel comprises the following steps: adding chitosan into a suspension containing activated platelet-rich plasma and stem cell exosome, uniformly mixing, adding a povidone suspending aid, oscillating to form a stable suspension state, adjusting the pH value to 7.5-7.8, mixing with thrombin and a calcium agent, stirring in a dark place, and solidifying to form a gelatinous substance, thereby obtaining the composite gel. The platelet-rich plasma-stem cell exosome-chitosan composite gel is obtained. The composition and the composite gel can promote microvascular endothelial cell regeneration and recover normal vascular endothelial morphology and functions; skin regeneration is promoted; broad-spectrum bacteriostasis and lipid reduction are realized, and local inflammation and immune response are inhibited.

The invention discloses an anti-inflammatory CAR-macrophage targeting FAP, a preparation method thereof and application of the anti-inflammatory CAR-macrophage in preparation of drugs for treating fibrosis diseases, and belongs to the technical field of biological medicines. The invention provides an FAP-specific chimeric antigen receptor, an mRNA expression vector of the FAP-specific chimeric antigen receptor, a His-labeled STING signal channel inhibitor and an mRNA expression vector of the His-labeled STING signal channel inhibitor. In-vivo and in-vitro macrophage editing can be effectively realized by delivering CAR mRNA and TRIM13mNRA through LNP, the ability of targeted phagocytosis of FAP positive cells is endowed, meanwhile, anti-inflammatory phenotypic polarization of macrophages is promoted, local inflammation is improved, and fibrosis progress driven by inflammation is synergistically restrained.

The invention belongs to the technical field of biological medicines, and particularly relates to an MAF vaccine as well as a preparation method and application thereof. In order to develop a nasal spray type vaccine capable of effectively preventing and treating fibrotic interstitial lung diseases and avoiding risk increase caused by local inflammatory reaction, the invention adopts two modes of taking a synthesized MAF protein as a model antigen, encapsulating the MAF protein by using a TLR7 adjuvant to form a peptide fragment vaccine or constructing an MAF adenovirus vaccine based on an adenovirus vector. Two vaccines based on the MAF target spot are successfully constructed. Animal experiment results prove that the two vaccines based on the MAF target spot have treatment and prevention effects on bleomycin-induced mouse pulmonary fibrosis models during nasal dripping immunization, and also have good safety in vivo. A good candidate vaccine is provided for future fibrotic disease prevention and treatment vaccine transformation research and clinical experiment development.

This invention relates to the field of medical information management technology, including an AI-based endometriosis management system. The system comprises a thickness dynamic monitoring module, an inflammation level assessment module, a lesion spread analysis module, a periodic lesion tracking module, and a disease progression analysis module. In this invention, AI is used to segment ultrasound image data, enabling dynamic monitoring of lesion areas. Lesion boundaries are extracted, and changes in local inflammatory marker concentrations are calculated, making the screening of abnormal inflammatory areas more accurate and enabling early identification of lesion development. The tracking of periodic lesions, combined with analysis of lesion contour changes and area increases / decreases, enhances the quantitative control of disease progression. The future development trend of lesions, combined with the calculation of periodic inflammatory pathways, makes the prediction of disease evolution more consistent with physiological changes. Multi-dimensional lesion analysis combined with AI intelligent calculation expands the diagnosis and treatment of endometriosis from static assessment to dynamic trend prediction, improving the adaptability of personalized treatment plans.

The invention discloses a preparation method of composite microspheres for regulating and controlling a local inflammation microenvironment and promoting nerve regeneration. The method comprises the following steps: preparing liposome loaded with ginsenoside Rg1; preparing a GM microsphere loaded with a stromal cell-derived factor 1 alpha (SDF1 alpha); and preparing the inflammation regulation nerve regeneration promoting composite microspheres. The composite microsphere can reduce inflammatory response, reduce scar tissue formation, promote angiogenesis, continuously release SDF1 alpha and promote endogenous stem cell recruitment and neural differentiation. Therefore, the composite microsphere is a functional biological scaffold for firstly regulating and controlling local microenvironment inflammation of spinal cord injury and then promoting collection and differentiation of endogenous stem cells for innovative sequential inflammation regulation and nerve regeneration, and a new strategy is provided for treating spinal cord injury by tissue engineering.

The present disclosure relates to a functionalized statistic chitosan of weight average molecular mass between 100 kDa and 1000 kDa and of formula (I):whereineach Rc is independently a moiety comprising a chelating agent,each Z is independently a linker which is a single bond or a hydrocarbon chain containing between 1 and 12 carbon atoms, said hydrocarbon chain is linear or branched and optionally contains one or more unsaturations and one or more heteroatoms,x is between 0.005 and 0.7, preferably between 0.05 and 0.7,y is between 0.01 and 0.7, preferably between 0.05 and 0.2,the ratio y / x being greater than or equal to 0.05, preferably greater than or equal to 0.15, andthe sum x+y being greater than or equal to 0.15, for use in the treatment of diseases characterized by local inflammation induced by and / or inducing a deregulation of metal homeostasis and increased oxidative stress, in a subject in need thereof.

According to the application of the hydrogel preparation loaded with the quercetin nanoparticles to preparation of a chronic difficult-to-heal wound surface treatment material, Que-coated HZ hydrogel is obtained through physical loading of QueNPs and crosslinking of modified hyaluronic acid and Zn < 2 + >, full-stage management of wound healing can be achieved, rapid healing and tissue regeneration of the wound surface are promoted through the synergistic effect of all the components, and the healing effect of the wound surface is improved. A comprehensive treatment strategy is provided for chronic wound surfaces difficult to heal, and the Que-coated HZ hydrogel promotes transformation of macrophages from an M1 phenotype to an M2 phenotype and shows a good anti-inflammatory effect. In the early stage, the hydrogel preferentially releases Zn < 2 + > to achieve the antibacterial effect and relieve local inflammation, in the later stage, QueNps gradually releases Que to reduce ROS generation, so that the anti-oxidation and anti-inflammatory effects are achieved, wound repair is accelerated, and meanwhile the released Que can resist mitochondrial damage and improve the mitochondrial function.

The invention discloses a traditional Chinese medicine tea drink for preventing and treating oral mucosa diseases and a preparation method of the traditional Chinese medicine tea drink. The traditional Chinese medicine tea drink is prepared from 10-15 parts of radix astragali, 8-12 parts of radix codonopsis, 6-10 parts of radix salviae miltiorrhizae, 5-9 parts of radix angelicae sinensis, 3-6 parts of fructus psoraleae, 6-9 parts of rhizoma polygonati, 6-9 parts of radix adenophorae, 6-10 parts of rhizoma atractylodis macrocephalae, 5-9 parts of radix ophiopogonis, 3-5 parts of radix glycyrrhizae, 4-6 parts of pericarpium citri reticulatae and 5-8 parts of herba taraxaci. Aiming at the core pathogenesis of low immunity, long-term deficiency, long-term deficiency and kidney-yang insufficiency of patients suffering from oral mucosa diseases, qi tonifying, blood activating and kidney-qi strengthening are taken as a core treatment method, the formula is scientific and reasonable, all the medicinal materials act synergistically, the overall immune function of the body is adjusted, T lymphocyte subpopulation imbalance and cell factor network disorder are improved, and the curative effect is good. The oral mucosa microcirculation is improved, local inflammation is relieved, the immunity of a patient is improved fundamentally, the recurrence rate of oral mucosa diseases is reduced, and the problems that an existing tea drink is not high in pertinence and limited in curative effect are solved. The tea drink is appropriate in taste, good in compliance, high in safety and suitable for people with various oral mucosa diseases and low immunity.

This invention relates to a hyaluronic acid composite hydrogel based on the supramolecular self-assembly of natural molecules and its preparation method, belonging to the field of gel formulation technology. The invention first involves the self-assembly of specific natural molecules or their derivatives possessing hyaluronidase inhibitory and anti-inflammatory activities into stable supramolecular self-assemblies through intermolecular non-covalent interactions. Subsequently, this supramolecular self-assembly is combined with hyaluronic acid through various interactions such as physical entanglement, hydrogen bonding, van der Waals forces, or appropriate chemical cross-linking to construct a composite hydrogel with a uniform internal structure and stable performance. This invention not only achieves long-term, controllable sustained release of natural active ingredients in the gel through supramolecular loading, continuously inhibiting hyaluronidase activity and local inflammatory responses, but also avoids the residual risks associated with high dosages of traditional chemical cross-linking agents, ultimately obtaining a high-quality product that meets the appearance and performance requirements of medical hyaluronic acid gels.

The invention relates to a zwitterionic polymer-curcumin nano-micelle as well as a preparation method and application thereof, and belongs to the technical field of nano-drugs. The technical problems that existing curcumin is low in bioavailability, poor in lipophilicity, low in solubility and the like are solved. According to the zwitterionic polymer-curcumin nano-micelle disclosed by the invention, the zwitterionic polymer is used as a carrier, and the curcumin is used as a loaded drug. In the zwitterionic polymer-curcumin nano-micelle, curcumin has wide anti-inflammatory, anti-oxidation and osteogenesis promoting effects, the zwitterionic polymer has the characteristics of low toxicity and high cell penetrability, and the zwitterionic polymer-curcumin nano-micelle formed by the zwitterionic polymer and curcumin has the advantages of the zwitterionic polymer and curcumin and has the advantages of low toxicity and high cell penetrability. The traditional Chinese medicine composition has good anti-inflammatory, anti-oxidation and osteogenesis promoting effects, can relieve local inflammation, and has a relatively good treatment effect on periodontitis. And the zwitterionic polymer can improve the defect of poor solubility of curcumin, curcumin can be slowly released, and meanwhile, the curcumin has relatively high biological safety.

The utility model discloses a dental crown fixing abutment structure convenient to disassemble, which relates to the technical field of medical equipment and comprises an implant retention screw, an abutment fixing seat is arranged on the outer side of the top of the implant retention screw, an abutment is butted on the abutment fixing seat, and a locking screw is arranged in the abutment. According to the dental crown fixing abutment structure convenient to disassemble, the abutment and the dental crown can be assembled and disassembled through fixing and disassembling of the locking screws, and the situation that the abutment is repeatedly taken and worn, mechanical stimulation is caused to gingival tissue when the abutment is taken off and worn, and local inflammatory response is induced is effectively avoided; multiple times of confirmation of in-position precision in the repeated wearing and taking-off process of the abutment are avoided, and the reworking frequency is reduced.

The invention belongs to the technical field of nail taking in the orthopedics department, and particularly discloses a medical broken nail taking device in the orthopedics department, the medical broken nail taking device comprises a handle, a plurality of anti-slip strips are installed on the outer side wall of the handle, a cylinder is fixedly connected to the outer side wall of the handle, the cylinder is hollow, and two limiting sliding rods are arranged in the cylinder in a penetrating mode; a locking device is arranged at the connecting position of each limiting sliding rod and the cylinder, the ends, away from the cylinder, of the two limiting sliding rods are jointly and fixedly connected with a base plate, a rotary nail taking mechanism is arranged on the base plate, and the rotary nail taking mechanism comprises a rotary cylinder rotationally connected to the base plate. Normal saline automatically flushes a nail taking wound through the flushing pipe, local inflammatory response, exudation and scar formation during nail taking are effectively avoided, the operation complexity is remarkably reduced, the operation steps are reduced, the operation efficiency is improved, meanwhile, the operation risk is reduced, and postoperative recovery of a patient is facilitated.

The invention discloses a female vaginal mucosa cell maintenance preparation and a preparation method and application thereof, and belongs to the technical field of biological agents, the female vaginal mucosa cell maintenance preparation is prepared from dental pulp mesenchymal stem cells, portulaca oleracea polysaccharide, lactic acid, quercitrin, glycerin and stem cell carriers, and vaginal injection paste is obtained by evenly mixing the dental pulp mesenchymal stem cells, the portulaca oleracea polysaccharide, the lactic acid, the quercitrin, the glycerin and the stem cell carriers through a proper amount of deionized water. The purslane polysaccharide and the dental pulp mesenchymal stem cells form a unique synergistic effect, through physical wrapping, the survival rate and delivery efficiency of the stem cells in a vaginal cavity are improved, local inflammatory response is inhibited, a microenvironment is optimized to support directional differentiation of the stem cells into epithelial cells, paracrine activity of the stem cells is enhanced, and repairable factors are released to promote cell-level regeneration. The problem of hormone dependence is solved, deep maintenance of targeted mucous membrane cells is achieved, limitation of an existing therapy is broken through by directly nourishing cells, activating and regenerating, enhancing barrier integrity and maintaining an acidic microenvironment, and an ideal treatment effect is achieved.

The invention belongs to the technical field of biological medicines, and particularly discloses application of a CD44 function inhibitor in preparation of a medicine for preventing or relieving radiation liver injury (RILD). Radioactive liver injury is often caused by hepatocellular carcinoma radiotherapy, and specific targeting drugs are lacked clinically. It is revealed for the first time that whether CD44 molecules on the surface of Kuhu cells are highly expressed after radiation, and the CD44 molecules are key hubs for driving RILD; the invention also provides a CD44 function inhibitor which is a specific targeting drug aiming at RILD, and the action mechanism of the CD44 function inhibitor is to effectively block polarization of radiation-induced Kuptake cells to pro-inflammatory phenotype by inhibiting the CD44 function, so that local inflammatory response, oxidative stress and hepatocyte injury of the liver are relieved. Experiments prove that the CD44 function inhibitor can relieve liver inflammation, improve liver function indexes and reduce liver cell death and tissue pathological damage, and a brand-new and targeted scheme for preventing and treating RILD is provided.

The invention discloses a stem cell medicine for pancreas islet repair and application, and belongs to the technical field of stem cell biology, and the stem cell medicine for pancreas islet repair is prepared by compounding a carrier, pancreatic progenitor cells and pancreas islet-like cells in proportion. The problems that in the prior art, due to the fact that stem cells are unstable in differentiation efficiency, poor in synergistic effect and poor in biocompatibility, islet injury cannot be repaired, and diabetes cannot be treated are solved. According to the present invention, the dual mechanisms of endogenous beta cell repair and exogenous beta cell supplement are adopted, and the beta cell function recovery and the group structure reconstruction are synchronously achieved through the reasonable ratio, such that the in-vivo blood glucose of the mouse is significantly reduced, the beta cell number and the glucose tolerance dose of the mouse are increased, and the low immunogenicity and the high anti-inflammatory property are simultaneously provided. The compound can be used for treating type I and type II diabetes mellitus, improving the insulin secretion function and relieving local inflammatory response of pancreas by promoting pancreas islet beta cell proliferation, and has application potential in treatment of type I and type II diabetes mellitus and pancreas islet repair.

The invention relates to the field of biological medicine, and discloses application of SCAP as a target spot in treatment or prevention of atherosclerosis. The invention proves that compared with normal control, SCAP expression of macrophages in aortic tissues of atherosclerosis patients is up-regulated. The invention proves that the progress of atherosclerosis can be obviously relieved by macrophage SCAP specific knockout. The invention also proves that macrophage SCAP specific knockout can improve aortic plaque lipid accumulation, and the local inflammation level is improved by influencing macrophage polarization to relieve atherosclerosis. According to the application, the application of the macrophage SCAP as a new target spot in treating or preventing the atherosclerosis is found.

The present invention relates to medicine and the pharmaceutical industry, and more particularly to agents capable of inhibiting inflammatory processes, and even more particularly to agents that have an antimicrobial, sorptive, angioprotective and wound-healing effect on local inflammatory processes of the skin and soft tissues, for use in surgery, traumatology and dermatology. What is proposed in the present invention is a combination including dexpanthenol, methyluracil and chloramphenicol, and also a pharmaceutical composition based thereon.

The invention provides an analysis method for relieving diabetic foot wound scars through tibia transverse movement, and belongs to the technical field of postoperative analys.The method comprises the steps that a New Zealand rabbit serves as an experimental subject, a diabetic rabbit model is built through alloxan, and a DFU wound model is built through femoral artery ligation; bone transport and VEGF (vascular endothelial growth factor) are used for intervention, and the following conclusions are obtained by observing changes of general conditions, pathological changes of skin tissues, inflammatory factors of skin tissues of New Zealand rabbits and expression levels of related genes and proteins in TGF-beta1 / Smad3 signaling pathways: 1, bone transport can inhibit expression levels of inflammatory factors IL-6, IL-18 and TNF-alpha; therefore, the infiltration degree of inflammatory cells in skin tissues can be reduced, and local inflammation and scarring can be effectively improved. 2, the bone transport can promote the expression of related protein on a TGF-beta1 / Smad3 signal channel, so that the effects of promoting muscle fiber contraction, revascularization and reducing scar generation are achieved;

1. The name of the design product: ultrasonic medicine cold spray therapeutic instrument. 2. The use of the design product: through the ultrasonic introduction effect, the medicine is introduced into the subcutaneous tissue through the skin, and the local inflammation is cooled, anti-inflammatory and detumescence through ultrasonic atomization cold spray. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

To provide parenteral nutrition formulations.SOLUTION: The present disclosure relates to multi-chamber containers and to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations reconstituted from and amino acid formulations. More specifically, the present disclosure relates to formulations comprising butyrate derivatives, specifically arginine butyrate, for use in adult or pediatric patients. The present disclosure further provides methods for reducing or preventing systemic and local inflammation in patients receiving parenteral nutrition, as well as methods for maintaining or improving their systemic and local immunity and intestinal barrier function.SELECTED DRAWING: None

The invention relates to an alkaloid liposome, a preparation process thereof and an application of the alkaloid liposome in an external preparation, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology which is higher in stability, safe and non-irritating. According to the scheme, the alkaloid liposome technology is characterized in that raw materials comprise alkaloid, hydrogenated lecithin, grease, polyhydric alcohols and water; the alkaloid is selected from at least three of piperine, tetrahydropiperine, tetrahydropalmatine, dihydrooat alkaloid D, caffeine and leonurine; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON80H or PhoslipTM HPC (Hydroxyethyl Propyl Phosphatidylcholine). The liposome is good in stability and low in irritation, and has the effects of promoting local tissue microcirculation, reducing choked flow rate, increasing local body temperature, enhancing tissue metabolism and improving local inflammation when being externally applied to skin.

The present application relates to the technical field of biological medicine, and particularly relates to Pseudogulbenkiania soli, outer membrane vesicles thereof and application. The present application provides a new method for treating or preventing liver fibrosis and related diseases by using Pseudogulbenkiania soli Pseudochrobactrum saccharolyticum The extracellular membrane vesicles of Pseudogulbenkiania soli and cells derived therefrom can significantly reverse the increase of serum liver function indicators of CCl4-induced liver fibrosis mice, and significantly reduce the histopathological damage of liver tissue. At the same time, both of them can effectively inhibit the local inflammatory response of liver and reduce the expression level of inflammatory factors. The above results show that Pseudogulbenkiania soli and its outer membrane vesicles can significantly improve the liver function damage, histological lesions and inflammatory state caused by CCl4 by regulating the inflammatory signaling pathway, and provide new experimental evidence and potential strategy for microbial intervention of liver fibrosis.

This invention relates to the field of biomedical technology, and in particular to a method for preparing and applying a nanomedicine for treating deep endometriosis. The method involves mixing ferrous ammonium sulfate, trisodium citrate, and polyethyleneimine, then adding thioacetamide and triethanolamine via a solvothermal reaction to obtain two-dimensional iron sulfide nanosheets. Dopamine hydrochloride is then added and stirred at room temperature in anhydrous ethanol to obtain polydopamine-coated iron sulfide (FP). FP is then mixed with larotrectinib and anhydrous ethanol to obtain the nanomedicine FPL for treating deep endometriosis. The synthesis method of this invention is simple and highly operable; the product is stable and reproducible; FPL exhibits good biocompatibility and biodegradability. After entering the microenvironment of deep endometriosis lesions, it can responsively release larotrectinib, effectively inhibiting the Trk signaling pathway and significantly reducing the degree of nerve infiltration; simultaneously, the anti-inflammatory effect of the FP carrier alleviates the local inflammatory response, jointly inhibiting lesion progression.

The invention discloses a full-tumor vaccine for ultrasonic enhancement of immune response and a preparation method thereof. According to the full-tumor vaccine with the ultrasonic enhanced immune response, the manganese vanadate nanosheets with acoustic catalysis and adjuvant effects serve as vaccine adjuvants and acoustic sensitizers, tumor cells taking in the manganese vanadate nanosheets are split to obtain the full-tumor vaccine, under ultrasonic excitation, the manganese vanadate nanosheets can generate ROS at the inoculation position, release of full-tumor cell vaccine antigens is promoted, and the immune response is enhanced. According to the present invention, the manganese vanadate nanosheet can induce local inflammation and promote the collection of innate immune cells and the antigen uptake ability of dendritic cells (DC), and the manganese ions released by the manganese vanadate nanosheet can activate the STING-IFN-I signal channel and promote the maturation of the DC, and after the mature DC uptake the antigen, the mature DC homes to the lymph node to activate the strong antigen-specific T cell immune response, after the full-tumor cell vaccine based on the manganese vanadate nanosheet is injected for a single time, the vaccine can be activated for multiple times as required through external field ultrasound, so that efficient treatment on tumors is realized.

The application discloses application of forskolin and / or isoforskolin in preparation of a medicine for preventing and / or treating colitis, and belongs to the technical field of medicines.The medicine can significantly improve the disease phenotype of colitis, including relieving weight loss, reducing disease activity index score, improving colon length shortening and histopathological damage.The mechanism of action involves multiple targets: repairing intestinal mucosal barrier function, reducing local inflammation of the colon, and regulating intestinal flora balance, restoring the abundance of beneficial bacteria and inhibiting the proliferation of pathogenic bacteria.The application provides a candidate drug with anti-inflammatory, barrier repair and flora regulation functions for the treatment of colitis, and expands the medical use of forskolin or isoforskolin.

The invention discloses an artificial vitreous body and a preparation method thereof, and belongs to the technical field of medical materials, and the preparation method comprises the following steps: preparing a buffer solution, preparing a polylysine solution, purifying the polylysine solution, preparing a cross-linking agent reaction solution, preparing sodium hyaluronate gel, and preparing the artificial vitreous body. According to the method disclosed by the invention, DMTMM chloride is selected as a condensing agent, so that the problem that unreacted BDDE monomers need to be removed by a complex purification process is avoided, and the production cost and the process complexity are reduced; the mutagenic risk possibly caused by BDDE residues and the local inflammation, immune response or retinal cell potential toxicity risk caused by non-specific reaction of epoxy groups and intraocular protein are eliminated, and the biological safety of the artificial vitreous body is remarkably improved.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

The invention discloses a CX3CL1 targeting chimeric antigen receptor-macrophage and application thereof in treatment of GJB2 mutation related hereditary deafness, the CX3CL1 targeting chimeric antigen receptor-macrophage directly converts a CX3CL1 mediated pro-inflammatory signal into an anti-inflammatory signal, so that the macrophage is directionally polarized to an M2 type, the anti-inflammatory repair function is exerted, and the GJB2 mutation related hereditary deafness can be treated by the CX3CL1 targeting chimeric antigen receptor-macrophage. A cochlea injury microenvironment is specifically responded, anti-inflammatory repair phenotypes are switched, and cochlea epithelial cells and spiral ganglion neurons are protected; the GJB2 mutation-related hereditary deafness inner ear local inflammation can be accurately improved, apoptotic cell debris removal is promoted, the whole body immune homeostasis is not interfered, and the GJB2 mutation-related hereditary deafness inner ear local inflammation has a remarkable drug treatment application prospect.

The invention belongs to the technical field of medicines, and particularly relates to application of beta-lactam compounds in preparation of anti-inflammatory drugs. Research finds and experiments prove that the beta-lactam compound inhibits tubulin aggregation by combining with the surfaces of alpha and beta tubulin, thereby inhibiting various cell processes participated by microtubules; the beta-lactam compound inhibits inflammatory reaction through the following ways: inhibition of immune activation, activation of NLRP3 inflammasome, and activation of Caspase-1; neutrophile granulocyte recruitment and adhesion and chemotactic factor release are inhibited; the secretion of vascular endothelial growth factors and the proliferation of endothelial cells are inhibited, so that the compound can be used for preparing anti-inflammatory drugs; comprise acute gout caused by inflammation, familial geothermal fever, chronic kidney disease, pancreatitis, sarcopenia and other local inflammatory reaction diseases and ischemia-reperfusion injury, diabetes, atherosclerosis, pericarditis, acute coronary syndrome and other inflammation-related cardiovascular diseases.