Cefcapene pivoxil granules and preparation method thereof

A technology of cefcapene axetil and granules, which is applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Problems such as poor stability, to achieve good business prospects, improved appearance, and high production efficiency
CN112402391APending Publication Date: 2021-02-26湖北凌晟药业股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
湖北凌晟药业股份有限公司
Publication Date
2021-02-26

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Abstract

The invention provides cefcapene pivoxil granules. The cefcapene pivoxil granules comprise medicine-containing granules and essence, wherein the medicine-containing granules consist of a core part anda coating layer wrapping the core part; the cefcapene pivoxil granules comprise the following components in percentage by weight: 97-99% of the medicine-containing granules and 1-3% of the essence, wherein the medicine-containing granules comprise the following components in percentage by weight: 0.5-5% of the coating layer and the balance of the core part, and the coating layer consists of a coating agent; and the core part comprises the following components in percentage by weight: 14-15% of cefcapene pivoxil, 10-30% of a disintegrating agent, 30-70% of a flavoring agent, 4-10% of a suspending agent and 1-10% of a pH regulating agent, wherein the pH regulating agent is one or more of citric acid, malic acid, tartaric acid and lactic acid. The cefcapene pivoxil granules prepared by the preparation method disclosed by the invention are good in solubility, appropriate in release speed, good in stability and good in taste.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a cefcapene pivoxil granule and a preparation method thereof. Background technique

[0002] Cefcapene Pivoxil Hydrochloride Hydrate (Cefcapene Pivoxil Hydrochloride Hydrate) is an oral cephalosporin antibiotic, which has the advantages of broad antibacterial spectrum and strong antibacterial activity. Its molecular formula is C 23 h 29 N 5 o 8 S 2 ·HCl·H 2 O, with a relative molecular weight of 622.11, is a white to pale yellowish white crystalline powder or a block with a slight peculiar smell, easily soluble in N,N-dimethylformamide, methanol, ethanol (99.5%), slightly soluble in water. Its structural formula is as follows:

[0003]

[0004] Cefcapene pivoxil hydrochloride hydrate is referred to as cefcapene pivoxil for short. When it is absorbed, it is hydrolyzed by intestinal wall esterase to generate antibacterial active cefcapine. Cefcapene play...

Claims

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