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Method for preparing electric response drug control system by zinc oxide nanoparticle-mediated high-toughness hydrogel

A zinc oxide nano and hydrogel technology, which is applied in electrotherapy, pharmaceutical formulations, conductive adhesives, etc., can solve the problems of single response, widening, and easy pollution, and achieve good chemical stability, simple process, The effect of high efficiency utilization

Active Publication Date: 2021-03-05
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel has good mechanical properties, self-healing properties, and electrical conductivity. At the same time, the antibacterial ability and acid-base responsiveness of nano-zinc oxide can improve the shortcomings of existing responsive hydrogels, single responsiveness, and easy pollution, and expand Broaden the application of hydrogel materials in drug delivery systems

Method used

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  • Method for preparing electric response drug control system by zinc oxide nanoparticle-mediated high-toughness hydrogel
  • Method for preparing electric response drug control system by zinc oxide nanoparticle-mediated high-toughness hydrogel
  • Method for preparing electric response drug control system by zinc oxide nanoparticle-mediated high-toughness hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1 mg of rod-shaped nano-zinc oxide particles were sonicated for 1 h to make them highly dispersed in a mixed solution of ethanol and water with a volume ratio of 9:1. Dissolve 30 mg of agar powder in the mixed solution, place it on a thermostatic mixer at 95° C. and stir at 1000 r / min at high speed for 2-3 hours, and wait for it to swell completely. Add 600 mL of N-hydroxyethylacrylamide monomer (HEAA) and an appropriate amount of photoinitiator. Then, stir at a constant temperature and high speed at a temperature of 40°C and a rotation speed of 1000r / min until the solution is clear and transparent. The obtained pregel solution is subjected to light polymerization. Finally, the pregel solution is first poured into a mold and covered with a PET film, and the wavelength is 365nm. 1. An ultraviolet lamp with a power of 10w was placed at a distance of 6cm above the pre-gel solution, and the light reaction was carried out for 0.5h to obtain a high-toughness hydrogel mediated...

Embodiment 2

[0032] 2 mg of rod-shaped nano-zinc oxide particles were sonicated for 1 h to make them highly dispersed in a mixed solution of ethanol and water with a volume ratio of 9:1. Dissolve 30 mg of agar powder in the mixed solution, place it on a thermostatic mixer at 95° C. and stir at 1000 r / min at high speed for 2-3 hours, and wait for it to swell completely. Add 700 mL of N-hydroxyethylacrylamide monomer (HEAA) and an appropriate amount of photoinitiator. Then, stir at a constant temperature and high speed at a temperature of 40°C and a rotation speed of 1000r / min until the solution is clear and transparent. The obtained pregel solution is subjected to light polymerization. Finally, the pregel solution is first poured into a mold and covered with a PET film, and the wavelength is 365nm. 1. An ultraviolet lamp with a power of 10w was placed at a distance of 6cm above the pregel solution, and the light reaction was carried out for 0.5h to obtain agar-zinc oxide nanoparticles / p(HEA...

Embodiment 3

[0034] 5 mg of rod-shaped nano-zinc oxide particles were sonicated for 1 h to make them highly dispersed in a mixed solution of ethanol and water with a volume ratio of 9:1. Dissolve 30 mg of agar powder in the mixed solution, place it on a thermostatic mixer at 95° C. and stir at 1000 r / min at high speed for 2-3 hours, and wait for it to swell completely. Add 600 mL of N-hydroxyethylacrylamide monomer (HEAA) and an appropriate amount of photoinitiator. Then, stir at a constant temperature and high speed at a temperature of 40°C and a rotation speed of 1000r / min until the solution is clear and transparent. The obtained pregel solution is subjected to light polymerization. Finally, the pregel solution is first poured into a mold and covered with a PET film, and the wavelength is 365nm. 1. An ultraviolet lamp with a power of 10w was placed at a distance of 6cm above the pre-gel solution, and the light reaction was carried out for 0.5h to obtain a high-toughness hydrogel mediated...

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Abstract

The invention discloses a method for preparing an electric response drug control system by zinc oxide nanoparticle-mediated high-toughness hydrogel. The method comprises the following steps: highly dispersing nano-zinc oxide particles in a mixed solution of water and ethanol to obtain a nano-zinc oxide dispersion liquid, dissolving agar powder in water, highly swelling the agar powder, and mixingthe agar powder with the above obtained solution; and adding an N-hydroxyethyl acrylamide monomer and 1wt% HEAA 2-hydroxy-4-(2-hydroxy ethoxy)-2-methyl propiophenone as a photoinitiator into a mixed solution, performing stirring and full reacting, pouring a pre-gel solution into a Teflon template, coating with a PET film, and carrying out illumination reaction for 1 hour under an ultraviolet lampwith the wavelength of 365 nm; ZnO nanorods are formed in an agar matrix in situ, zinc nanoparticles are oxidized by an ethanol solution firstly, and then a high polymer p (HEAA) is used for improvingthe toughness. The zinc oxide nanoparticle-mediated high-toughness hydrogel prepared by the method has excellent strength and good conductivity.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and relates to a method for preparing an electric response drug control system prepared by zinc oxide nanoparticle-mediated high-toughness hydrogel. Background technique [0002] Since the first TTS-scopolamine patch for the treatment of motion sickness was launched in the United States in 1981, the clinical application of transdermal absorption preparations has been generally welcomed. Transdermal drug delivery can avoid the problems existing in traditional drug delivery methods, improve the predictability of drugs in the body, avoid the first-pass effect of the liver and the degradation of drugs in the gastrointestinal tract, and overcome the problems caused by excessive blood drug concentration caused by excessive absorption. Adverse reactions caused by it; sustainable control of drug administration speed, flexible drug administration, etc. Moreover, the transdermal admin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J5/18C08L33/24C08L5/12C08K3/22A61K50/00A61K9/06A61K47/02A61K47/32
CPCC08J3/075C08J5/18A61K9/06A61K47/02A61K47/32C08J2333/24C08J2405/12C08K2003/2296C08K2201/011
Inventor 冯章启李瑞金飞李通杜丽娟
Owner NANJING UNIV OF SCI & TECH
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