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Drug-loaded microsphere-microneedle array for uniform drug administration, preparation method and application

A technology of drug-loaded microspheres and microneedle arrays, which is applied in the directions of microneedles, pharmaceutical formulations, and drug devices, can solve the problems of uneven distribution of microspheres, easy to fall off, etc., to overcome uneven distribution and easy to fall off, select The effect of broad, strong practical value

Pending Publication Date: 2021-03-09
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to address the deficiencies of the prior art, to provide a uniform drug-loaded microsphere-microneedle array, preparation method and application, so as to solve the problem that the microspheres are unevenly distributed and easy to fall off at the wound site

Method used

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  • Drug-loaded microsphere-microneedle array for uniform drug administration, preparation method and application
  • Drug-loaded microsphere-microneedle array for uniform drug administration, preparation method and application
  • Drug-loaded microsphere-microneedle array for uniform drug administration, preparation method and application

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preparation example Construction

[0030] The invention provides a method for preparing a drug-loaded microsphere-microneedle array for uniform administration, comprising the following steps:

[0031] S1. Preparation of drug-loaded microspheres

[0032] The drug is mixed with the hydrogel to prepare a mixed solution of hydrogel and drug as the internal phase, and the external phase is an oil phase (sunflower oil) that is incompatible with the internal phase, and the external phase and the internal phase are injected into the microfluidic device. The shear force between the two-phase solutions forms monodisperse single-emulsion droplets, and the droplet size can be changed by adjusting the flow rate of the microfluidic inner and outer phases; the droplets are cured by UV and collected, rinsed with alcohol and deionized water Several times, polymer drug-loaded microspheres with uniform particle size (diameter between 100-300 μm) were obtained; the hydrogel was selected from methacrylated hydrogel (GelMA), hyaluro...

Embodiment 1

[0035] Example 1——Preparation of uniform drug-loaded microsphere-microneedle array

[0036] S1. Preparation of drug-loaded microspheres

[0037] The microfluidic device was prepared by capillary with an outer diameter of 1 mm and an inner diameter of 500 μm. The inner phase tube was machine-drawn and ground into the required diameter, the outer phase tube was treated with octadecyltrimethoxysilane for hydrophobic treatment, and the inner and outer phase tubes were assembled coaxially. ; The internal phase tube is connected with 20% GelMA solution, VEGF solution and 1% photoinitiator mixed solution, the external phase tube is connected with sunflower oil, and the flow rate of the internal and external phases is controlled by a peristaltic pump to control the droplet size; the single emulsion produced by vertical irradiation with ultraviolet light The droplets were dropped for 30 s, and then washed 3 times with absolute ethanol and ultrapure water for 1 minute each time to obtai...

Embodiment 2

[0040] Example 2——Preparation of uniform drug-loaded microsphere-microneedle array

[0041] S1. Preparation of drug-loaded microspheres

[0042] A microfluidic device was prepared by capillary with an outer diameter of 1 mm and an inner diameter of 800 μm. The inner phase tube was machine-drawn and ground into the required caliber, the outer phase tube was treated with octadecyltrimethoxysilane for hydrophobic treatment, and the inner and outer phase tubes were coaxially assembled ; The internal phase tube is connected with 15% GelMA solution, VEGF solution and 1% photoinitiator mixed solution, the external phase tube is connected with sunflower oil, and the flow rate of the internal and external phases is controlled by a peristaltic pump to control the droplet size; the single emulsion produced by vertical irradiation with ultraviolet light The droplets were dropped for 30 s, and then washed 3 times with absolute ethanol and ultrapure water for 1 minute each time to obtain dr...

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Abstract

The invention provides a drug-loaded microsphere-microneedle array for uniform drug administration, a preparation method and application. According to the method, based on a microfluidic chip, hydrogel drug-loaded microspheres with uniform particle size and good monodispersity are prepared, the drug-loaded microspheres are placed in a microneedle template filled with a hydrogel solution, and the polymeric microsphere-microneedle array is demolded after solidification. The drug-loaded microspheres in the prepared microsphere-microneedle array have good sphericity and drug release rate, and microneedles penetrate into the skin to assist the microspheres to be uniformly distributed subcutaneously, so that the purpose of uniform and convenient transdermal drug administration is achieved; and the prepared drug-loaded microsphere-microneedle array has the advantages of being good in drug encapsulation, low in preparation cost, easy to operate and the like, and is high in practicability and suitable for popularization.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a drug-loaded microsphere-microneedle array for uniform administration, a preparation method and an application thereof. The drug-loaded microsphere-microneedle array can be applied to the skin for painless delivery medicine and other technical fields. Background technique [0002] Hydrogel microspheres are an efficient drug microcarrier. Due to the advantages of softness, good biocompatibility, degradability and high drug encapsulation rate, the hydrogel is widely used in the field of drug delivery. Traditional ways of delivering microspheres to wound sites include jetting, subcutaneous injection, etc. Due to the strong adhesiveness of the polymer microspheres, when they are released at the lesion site, the microspheres are easy to adhere to each other and aggregate, resulting in uneven drug release, low efficiency, and long recovery time of the wound site. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/14A61K47/32A61K47/34A61K47/36A61K47/44A61M37/00
CPCA61K9/0021A61K47/36A61K47/34A61K47/32A61K47/10A61K47/14A61K47/44A61M37/0015A61M2037/0053
Inventor 赵远锦樊璐王月桐张大淦商珞然
Owner NANJING DRUM TOWER HOSPITAL
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