Application of slc5a12 protein in seminal plasma extracellular vesicles

A 1. SLC5A12, protein technology, applied in the field of protein detection, can solve the problem of difficult detection and analysis of low-abundance proteins
CN112485322BActive Publication Date: 2022-02-11NANJING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING MEDICAL UNIV
Publication Date
2022-02-11

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Abstract

The application of seminal plasma extracellular vesicle SLC5A12 protein belongs to the field of protein detection. The present invention uses TMT labeling technology to quantitatively analyze the proteins carried by sEVs in NS, NOA and OA groups, and identifies differential proteins between groups, and uses PRM technology to successfully verify The biomarker SLC5A12 was identified, which can be used to diagnose non-obstructive azoospermia and obstructive azoospermia.
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Description

technical field

[0001] The invention belongs to the field of protein detection, and in particular relates to the application of biomarkers for the differential diagnosis of seminal plasma cell extracellular vesicles in obstructive and non-obstructive azoospermia. Background technique

[0002] Azoospermia accounts for about 10%-15% of all infertile men, and it is usually divided into two categories: obstructive azoospermia (OA) and non-obstructive azoospermia (NOA). The spermatogenesis function in the testes of OA patients is normal, but the obstruction of the male reproductive tract, such as pathological blockage of the epididymis, vas deferens or ejaculatory duct, or congenital abnormalities lead to sperm transport obstacles, accounting for about 40% of all azoospermia cases. NOA is one of the most serious forms of male infertility caused by testicular failure. Accurate diagnosis and classification of azoospermia is crucial, because the methods of sperm collection and trea...

Claims

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