Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hydrophilic gel sustained-release tablet containing echinacoside as well as preparation method and application thereof

A technology of echinacoside and hydrophilic gel, which is applied to medical preparations containing active ingredients, medical preparations without active ingredients, and pharmaceutical formulas, and can solve the problems of large daily doses, frequent takings, and safety issues. Low-level problems, to achieve the effect of reducing the frequency and dose of taking, reducing toxic and side effects, and enhancing compliance

Active Publication Date: 2021-03-16
JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although echinacoside is a known pharmaceutically active substance, the daily dosage is relatively large, the frequency of taking it is high, the safety is low, and it is easy to miss a dose

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydrophilic gel sustained-release tablet containing echinacoside as well as preparation method and application thereof
  • Hydrophilic gel sustained-release tablet containing echinacoside as well as preparation method and application thereof
  • Hydrophilic gel sustained-release tablet containing echinacoside as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0082] Preferably, the present invention provides a method for preparing the above-mentioned hydrophilic gel sustained-release tablet containing echinacoside, comprising the following steps:

[0083] The echinacoside and the solubilizing and chelating agent solution are mixed, filtered and dried to obtain the solubilizing and chelating agent inclusion complex of echinacoside.

[0084] The mass ratio of the echinacoside to the solubilizing and chelating agent is preferably 1:1.

[0085] Then the above inclusion compound is mixed with a release retardant and a first filler, and granulated.

[0086] Then, the granules obtained above are mixed with a glidant and a second filler, and compressed into tablets to obtain tablet cores.

[0087] The above-mentioned tablet core is coated to obtain the hydrophilic gel sustained-release tablet containing echinacoside.

[0088] The above-mentioned granulation is preferably wet granulation.

[0089] In some specific embodiments of the pres...

Embodiment 1

[0106] Prepare according to the dosage of prescription 1 in Table 1.

[0107] Preparation method: crush echinacoside to prepare chelate, sieve, fully mix with hydroxypropyl methylcellulose K15M, hydroxypropyl methylcellulose K4M, microcrystalline cellulose, make soft material, and granulate ;Dried, granulated, added lactose, silicon dioxide, mixed evenly, compressed into tablets, coated.

[0108] (1) Grind 360 parts by weight of echinacoside, pass through a 100-mesh pharmacopoeia sieve, weigh according to the prescription, mix with β-cyclodextrin sulfobutyl ether sodium solution in a ratio of 1:1, stir evenly, and filter , dried, and passed through a 100-mesh pharmacopoeia sieve to obtain echinacoside-β-cyclodextrin sulfobutyl ether sodium clathrate (that is, ECH-(SBE)7m-β-CD, 1:1), for subsequent use;

[0109] (2) Take each adjuvant according to the prescription ratio respectively, fully mix the raw material with the hydroxypropyl methylcellulose K15M of 250 parts by weight,...

Embodiment 2

[0115] Prepare according to the dosage of prescription 2 in table 1.

[0116] Preparation method: crush echinacoside to prepare chelate, sieve, fully mix with hydroxypropyl methylcellulose K15M, hydroxypropyl methylcellulose K4M, microcrystalline cellulose, make soft material, and granulate ;Dried, granulated, added lactose, silicon dioxide, mixed evenly, compressed into tablets, coated.

[0117] Concrete processing parameter is with embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention provides a hydrophilic gel sustained-release tablet containing echinacoside, which comprises the following components in parts by weight: 200 to 400 parts of echinacoside, 200 to 400 parts of solubilizing chelating agent, 300 to 600 parts of release retardant, 100 to 180 parts by weight of filling agent; 10-80 parts by weight of flow aid; and 10 to 80 parts of coating material. The solubilizing chelating agent is selected from one or more of cyclodextrin and derivatives thereof. In-vitro tests show that the sustained-release preparation is continuously and stably released within24 hours, and provides a new choice for preventing and treating senile dementia and other diseases. Compared with common tablets, the frequency and dosage of taking are reduced, the hydrophilic gel sustained-release tablet enhances the medication compliance of patients with related diseases, improves the water solubility of the medicine, increases the bioavailability of the medicine, improves themedication safety, and enhances the curative effect of echinacoside on senile dementia and other diseases. Meanwhile, the sustained-release tablet is simple in preparation process and beneficial to industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a hydrophilic gel sustained-release tablet containing echinacoside, a preparation method and application thereof. Background technique [0002] Sustained-release preparation (Sustained-release preparation) is usually based on the diffusion, dissolution, penetration and ion exchange of the drug and the properties of the gastrointestinal tract, by means of preparations, such as coating, adding blockers, etc., to delay the release of the drug in the body, The drug release rate and the delivery speed of the preparation in the process of absorption, distribution, metabolism and excretion, so that the drug can achieve a long-acting preparation. In the prescribed release medium, the drug is released slowly and at a constant rate as required; compared with the corresponding common preparation, the blood drug concentration process in the body is stable, the peak-to-val...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K9/22A61K31/7048A61K47/40A61K47/38A61K47/26A61P25/28
CPCA61K9/28A61K9/2054A61K9/205A61K9/2018A61K31/7048A61P25/28
Inventor 孙彦辉岳玉荣易斌韩雅慧肖艳皎陈明霞颜凡莉姜海燕牟海迪
Owner JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com