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Absorbable spongy bone wax with hemostatic and bone healing promoting functions and preparation method of absorbable spongy bone wax

A spongy, bone wax technology, applied in the field of biomedical engineering materials, can solve problems such as affecting the effect of bone graft fusion, and achieve excellent hemostatic effect, no immunogenicity, and simple production process.

Inactive Publication Date: 2021-03-16
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are a large number of literatures at home and abroad that have reported many cases of fracture nonunion caused by the application of traditional bone wax to stop bleeding during surgery; especially in spinal surgery, applying bone wax will inevitably affect the fusion effect after bone grafting. In almost all cases with poor fusion effect, traditional bone wax was used for hemostasis during operation

Method used

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  • Absorbable spongy bone wax with hemostatic and bone healing promoting functions and preparation method of absorbable spongy bone wax
  • Absorbable spongy bone wax with hemostatic and bone healing promoting functions and preparation method of absorbable spongy bone wax
  • Absorbable spongy bone wax with hemostatic and bone healing promoting functions and preparation method of absorbable spongy bone wax

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of silk fibroin solution, including the following steps:

[0030] (1) NA with a mass fraction of 0.5% 2 CO 3 The solution is boiled for 5 times, 1 hour each time, the temperature is 100 ° C, the bath ratio is L: 100, then washed with distilled water, naturally dried to obtain a pure silk fiber;

[0031] (2) CACL with molar ratio of 1: 2: 2: 8 2 CH 3 CH 2 OH and H 2 O mixed three-membered solvent dissolution step (1) obtained by the purifier fibers, the mass ratio of the three-membered solvent and the silk fibers is 10: 1, stirred at 75 to 80 ° C for 1 to 2 hours, resulting mixture;

[0032] (3) After cooling the mixed solution obtained by step (2), injecting the cellulose dialysis film, in 2005 to 4 days, the dialyzed solution is stored at 4 ° C, that is, the mass volume concentration is 4 % Filament protein solution.

Embodiment 2

[0034] Preparation of quaternized chitosan / modified starch composite microspheres, including the following steps:

[0035] (1) 10 g of soluble starch and 10 g of quaternized chitosan are weed in the beaker, and 100 ml of purified water is added, heated with a water bath to 95 ° C with a water bath, and use a 1% sodium hydroxide solution with a 1% sodium hydroxide solution. Adjust pH ≥ 10 to obtain a germline / quaternized chitosan complex;

[0036](2) Weigh 0.8 g of sodium triosphate and 0.8 g of PEG are placed in a beaker, and 30 ml of purified water is stirred and dissolved, then the germplasm / quaternized chitosan complex obtained by adding step (1) Uniform and mixed, resulting in a mixed solution;

[0037] (3) Take 150 ml of olive oil, add 2G span80, stir the dissolution to 50 ° C in a 60 ° C water bath, then slowly drop into the mixed solution obtained by step (2), after the drop is completed, then continue to react 6h, then Place overnight in the 4 ° C refrigerator, then ...

Embodiment 3

[0039] The preparation of sponge bone wax can be absorbed, including the following steps:

[0040] Example 1 was prepared, and the quaternized chitosan / modified starch composite microspheres, and β-TCP were stirred at 400 rpm at 400 rpm for 24 h, and then mixed even in -80. Freeze the sponge bone wax at ° C for 24 h at ° C. In the present embodiment, the mass ratio of quaternized chitosan / modified starch composite microspheres, β-phosphate and silk fibroin protein solution is, quaternized chitosan / modified starch composite microspheres: β - Trical calcium phosphate: Silin protein solution = 50 mg: 10 mg: 1 ml.

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Abstract

The invention discloses a preparation method of absorbable spongy bone wax with hemostatic and bone healing promoting functions. The preparation method comprises the following steps: uniformly mixingquaternized chitosan / modified starch composite microspheres with beta-tricalcium phosphate and a silk fibroin solution, and performing freeze drying to obtain the absorbable spongy bone wax. The absorbable spongy bone wax with hemostatic and bone healing promoting functions is prepared by combining a specific raw material ratio with a preparation process. Due to the fact that the raw materials have good biocompatibility and can be absorbed by the human body, the prepared spongy bone wax can be absorbed by the human body, residues are avoided, and bone wound healing is facilitated. Secondly, due to the action of the quaternized chitosan / modified starch composite microspheres, the bone wax has a good hemostatic effect, has certain antibacterial and anti-inflammatory effects, and has a good effect of promoting bone wound healing. Beta-TCP with bone induction and bone guidance effects is also added into the bone wax, so that the bone wax can promote repair of bone defect parts in bone wounds.

Description

Technical field [0001] The present invention belongs to the technical field of biomedical engineering materials, and more particularly to absorbable sponge bone waxes and preparation methods having hemorrhage and flexible healing function. Background technique [0002] In the orthopedic surgery, there is more difficult problems that are not difficult to completely stop bleeding in orthopedic surgery. The structure of the pine bone is loose, and the blood is rich in the formation of the sinus, the vasoconstriction in the organization is poor, and the wound is mostly sharp cut, the violent blow is caused, and the hemorrhage is mostly oozed. It is different from other tissue bleeding, it is difficult to rely The blood vessel contraction is self-hemostasis, and it is difficult to rely on electrical ghosts, clamps, hemostasis, glue sponge fills and other conventional methods. The most effective hemostatic hemostasis method is rapidly filled with rocky bone surface cracks, sinus, suspe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/10A61L24/00
CPCA61L24/0015A61L24/0036A61L24/0042A61L24/0094A61L24/02A61L24/108A61L2300/112A61L2300/404A61L2300/41A61L2300/412A61L2300/418A61L2400/04
Inventor 蓝咏刘玉柯晓马春铭
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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