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Micro/nano hierarchical porous microspheres as well as preparation method and application thereof

A graded porous and nano-technology, applied in the fields of application, pharmaceutical formulation, pharmaceutical science, etc., can solve the problem of difficulty in improving the effect, and achieve the effect of reducing the possibility, not easy to slip off, and shortening the time of wound hemostasis.

Active Publication Date: 2021-03-23
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the hemostatic materials other than powder are only suitable for dentistry and surgery, and it is difficult to play a role in life accidents and military incidents, especially for sensitive wounds such as the head, neck, chest, abdomen and torso that cannot be pressed , the effect is even more difficult to improve

Method used

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  • Micro/nano hierarchical porous microspheres as well as preparation method and application thereof
  • Micro/nano hierarchical porous microspheres as well as preparation method and application thereof
  • Micro/nano hierarchical porous microspheres as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation of the mixed solution (CS / Ch) of embodiment 1 chitin nanofiber and chitosan

[0053] Add a certain quality of chitin into ionized water to prepare chitin solutions with a concentration of 0wt%, 0.1wt%, 0.2wt%, 0.5wt%, and 1.0wt%, and add 1% acetic acid solution by volume to adjust the pH value to 3 ~4, Stir for 24 hours, grind with a grinder, the grinding pressure is 200MPa, the grinding times is 50times, and then dispersed by a high-speed homogenizer, the speed is 10000rpm, the homogenization time is 1h, and a stable and uniform suspension of chitin nanofibers is obtained . Take a certain amount of chitosan powder and add it into an acetic acid solution with a volume ratio of 1%. The concentration of the chitosan solution is 2.0 wt%, and mechanically stir until the chitosan is completely dissolved. The same volume of chitin nanofiber suspension and chitosan solution were taken, mixed, and homogenized by a high-speed homogenizer at a speed of 8000 rpm a...

Embodiment 2

[0054] The preparation of the mixed solution of embodiment 2 chitin nanofibers and chitosan

[0055] Add a certain quality of chitin into ionized water to prepare a chitin solution with a concentration of 0.2wt%, add 1% acetic acid solution by volume to adjust the pH value to 3-4, stir for 24 hours, grind with a grinder, and the grinding pressure is 300MPa , the number of times of grinding is 30times, and then dispersed by a high-speed homogenizer with a rotating speed of 9000rpm and a homogenization time of 1.5h to obtain a stable and uniform suspension of chitin nanofibers (fiber length is 100nm). Take a certain amount of chitosan powder and add it into an acetic acid solution with a volume ratio of 2%, the concentration of the chitosan solution is 3.0 wt%, and mechanically stir until the chitosan is completely dissolved. The same volume of chitin nanofiber suspension and chitosan solution were taken, mixed, and homogenized by a high-speed homogenizer at a speed of 10,000 rp...

Embodiment 3

[0056] The preparation of the mixed solution of embodiment 3 chitin nanofibers and chitosan

[0057] Add a certain quality of chitin into ionized water to prepare a chitin solution with a concentration of 0.5wt%, add 1% acetic acid solution by volume to adjust the pH value to 3-4, stir for 24 hours, grind with a grinder, and the grinding pressure is 400MPa , the number of times of grinding is 40times, and then dispersed by a high-speed homogenizer with a rotating speed of 12000rpm and a homogenization time of 2h to obtain a stable and uniform suspension of chitin nanofibers (fiber length is 50nm). Take a certain amount of chitosan powder and add it into an acetic acid solution with a volume ratio of 2%, the concentration of the chitosan solution is 3.0 wt%, and mechanically stir until the chitosan is completely dissolved. The same volume of chitin nanofiber suspension and chitosan solution were taken, mixed, and homogenized by a high-speed homogenizer with a homogenization spe...

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Abstract

The invention discloses micro / nano hierarchical porous microspheres as well as a preparation method and application thereof. The preparation method comprises the following steps of (1) preparing a mixed solution of chitin nanofibers and chitosan; (2) preparing a Pickering emulsion; and (3) preparing the micro / nano hierarchical porous microspheres. The preparation method is simple, mild in reactioncondition and low in cost; red blood cells and blood platelets are prevented from entering the microspheres by controlling the pore sizes of the outer surfaces of the prepared microspheres, so that the wound hemostasis time is shortened and wound repair is promoted; the pore walls of the microspheres are connected by chitin nanofibers, so that collagen fiber forms in subcutaneous matrixes in vascular tissues can be simulated; the blood platelets are adhered and activated, so that the acceleration of hemostasis is facilitated, wound surface blood is effectively adsorbed, and the wound surfaceis kept dry; and when the chitosan is in contact with blood, the structure of polycations of the chitosan and the binding force between molecules of the chitosan and cell membranes enable whole bloodto be coagulated, so that the hemostatic process is accelerated, wound infection is inhibited, and cell proliferation is promoted.

Description

technical field [0001] The invention relates to the technical field of novel medical hemostatic materials, in particular to a micro / nano graded porous microsphere and a preparation method and application thereof. Background technique [0002] Wound bleeding is the leading cause of death in military operations, traffic accidents, and surgery. Of the deaths from haemorrhage, about 50% are combat deaths in the military and about 15-25% are trauma in civilian hospitals. Severe wounds are prone to infection, impairing the natural healing process and even leading to life-threatening sepsis. Therefore, rapid hemostasis is not only a necessary strategy for initial survival, but also the most ideal means of recovery. At present, commonly used hemostatic materials include gelatin, starch, silicon dioxide, hydrogel, cellulose sponge, nanofiber, etc. There are also many hemostatic products on the market, however, the efficacy of these products varies significantly and has not been ev...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/043A61L24/0036A61L24/001A61L2400/12A61L2400/04C08L5/08
Inventor 焦延鹏谭莉慧周长忍
Owner JINAN UNIVERSITY
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