Composite bone repair material with light display effect and self-positioning function and preparation method thereof

A self-positioning, bone repair technology, applied in the field of biomedical engineering, can solve problems such as increasing the complexity of the manufacturing process, achieve the effect of good biomechanical matching performance and wide application prospects

Active Publication Date: 2021-03-26
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyamino acid, like other polymers, is easily transmitted by X-rays, and needs to be developed and positioned by adding tantalum or titanium metal to the polymer artificial vertebra. This method not only increases the complexity of the manufacturing process, but also leads to lifelong long-term retention Therefore, it is very important to find a more scientific and reasonable light display and positioning method
[0006] In the prior art, there are no related reports on bone repair materials with light effect and self-positioning function

Method used

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  • Composite bone repair material with light display effect and self-positioning function and preparation method thereof
  • Composite bone repair material with light display effect and self-positioning function and preparation method thereof
  • Composite bone repair material with light display effect and self-positioning function and preparation method thereof

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Experimental program
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preparation example Construction

[0040] The invention provides a method for preparing a polyamino acid composite bone repair material with a light effect and a self-positioning function, comprising the following steps:

[0041] (1) 3,4,9,10-perylenetetracarboxylic acid diamide (I) with double amino terminal is reacted with 3,4,9,10-perylenetetracarboxylic dianhydride and aliphatic diamine, and then reacted with lanthanum System elements react to form 3,4,9,10-perylenetetracarboxylic acid diamide diacid salt (II) with light effect; 3,4,9,10-perylenetetracarboxylic acid diamide diacid salt (II) The photoelectric effect of the ring structure cooperates with the photoelectric effect of lanthanide ions, which can emit light at a certain wavelength or block X-rays to form an image, so that it has the positioning function of the material under light and radiation; the specific reaction formula is as follows:

[0042]

[0043] (2) Synthesizing a polyamino acid (III) with an amino end group as a main chain polyamin...

Embodiment 1

[0055] In a 3L three-necked flask with dry nitrogen protection, stirring and a thermometer, add 392.32g of 3,4,9,10-perylenetetracarboxylic dianhydride dried in vacuum at 80°C, and 1L of calcined calcium oxide dried N,N-dimethylacetamide (DMAc), stirred under the protection of dry nitrogen, added 116.2g of dried 1,6-hexamethylenediamine, and stirred at room temperature for 6 hours. Then add 80g of dried erbium oxide, and continue to stir at normal temperature for 6 hours under the protection of nitrogen. Then pour the reaction solution into normal temperature deionized water, stir and wash, repeat 4 times, and wash 2-3 times with absolute ethanol. Dry in a vacuum oven at 60°C for 10 hours. 650 g of erbium salt (II) of 3,4,9,10-perylenetetracarboxylic acid diamide diacid was obtained.

[0056] Weigh 1050g of ε-aminocaproic acid, 130g of hydroxyproline, and 150g of lysine respectively, add them into a 2500ml three-necked bottle, add 500ml of distilled water, protect with nitro...

Embodiment 2

[0062]In a 3L three-necked flask with dry nitrogen protection, stirring and a thermometer, add 392.32g of 3,4,9,10-perylenetetracarboxylic dianhydride dried in vacuum at 80°C, and 1L of calcined calcium oxide dried N,N-dimethylacetamide (DMAc), stirred under the protection of dry nitrogen, added 116.2g of dried 1,6-hexamethylenediamine, and stirred at room temperature for 6 hours. Then add 80g of dried erbium oxide, and continue to stir at normal temperature for 6 hours under the protection of nitrogen. Then pour the reaction solution into normal temperature deionized water, stir and wash, repeat 4 times, and wash 2-3 times with absolute ethanol. Dry in a vacuum oven at 60° C. for 10 hours; obtain 650 g of 3,4,9,10-perylenetetracarboxylic diamide erbium salt (II).

[0063] Weigh 1162g of ζ-aminoheptanoic acid, 130g of hydroxyproline, and 150g of lysine respectively, add them to a 2500ml three-necked bottle, add 500ml of distilled water, protect with nitrogen, stir and heat up...

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Abstract

The invention relates to a composite bone repair material with a light display effect and a self-positioning function and a preparation method thereof, and belongs to the field of biomedical engineering. The invention provides the preparation method of the composite bone repair material with the light display effect and the self-positioning function, and the preparation method comprises the following steps of 1) preparing 3,4,9,10-perylenetetracarboxylic diamide diacetate with a light effect; 2) preparing polyamino acid with free amino groups; 3) preparing polyamino acid with 3,4,9,10-perylenetetracarboxylic diamide diacetate amide salt; and 4) preparing a polyamino acid composite bone repair material with a light display effect and a self-positioning function. The prepared composite bonerepair material according to the present invention achieves a light display effect and a self-positioning function, can emit light automatically under a certain wavelength and can be positioned automatically, so that great convenience is brought for surgical operation; meanwhile, the bending strength can reach 130 MPa, and the modulus can reach 8 GPa; and the compressive strength can reach 150 MPa, and the modulus can reach 10 GPa.

Description

[0001] technology field [0002] The invention relates to a composite bone repair material with light effect and self-positioning function and a preparation method thereof, belonging to the field of biomedical engineering. Background technique [0003] The adult spine consists of 26 vertebrae (7 cervical, 12 thoracic, 5 lumbar, 1 sacral (5 at birth), 1 coccyx), connected by ligaments, joints and intervertebral discs. The upper end of the spine supports the skull, connects the hip bones below, attaches the ribs in the middle, and serves as the back wall of the thorax, abdomen, and pelvis. The spine has the functions of supporting the trunk, protecting the internal organs, protecting the spinal cord and performing movements. The inside of the spine forms a longitudinal spinal canal from top to bottom, containing the spinal cord. Due to physiological diseases, daily life habits, and various diseases and injuries, the deformation, injury, and functional degeneration of the spine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/50A61L31/06A61L31/02A61L31/18
CPCA61L27/18A61L27/12A61L27/50A61L31/06A61L31/028A61L31/18A61L2430/02A61L2430/38C08L77/04
Inventor 焦雪菲邓光进
Owner 中鼎凯瑞科技成都有限公司
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