Composition for daily prevention and treatment of microthrombus and application

A composition and micro-thrombosis technology, applied in the field of biomedicine, can solve the problems of liver and kidney toxicity, inconvenient use, short half-life, etc., and achieve the effect of improving old thrombus, reducing thrombus formation, and less side effects

Pending Publication Date: 2021-04-06
陕西中鸿科瑞再生医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For thromboembolic diseases, thrombolytic therapy is currently the main clinical treatment. Some commonly used thrombolytic drugs are streptokinase, urokinase, tissue plasminogen activator (t-PA), etc., but these drugs are present in varying degrees. Large side effects, strong toxicity, short half-life, inconvenient use, expensive, etc.
In addition, statins and anti-platelet aggregation (such as aspirin enteric-coated tablets, clopidogrel, etc.) drugs for daily prevention of thrombosis are less effective and often have liver and kidney toxicity
And there is currently a lack of drugs that specifically dissolve or prevent microthrombosis on a daily basis

Method used

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  • Composition for daily prevention and treatment of microthrombus and application
  • Composition for daily prevention and treatment of microthrombus and application
  • Composition for daily prevention and treatment of microthrombus and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A composition for daily prevention and treatment of microthrombosis, which is made of the following materials in parts by weight: 10 parts of ground dragon protein, 20 parts of nattokinase, and 20 parts of corn silk.

[0024] The preparation method of the composition for daily prevention and treatment of microthrombosis in this embodiment is as follows:

[0025] Weigh each raw material according to the above parts by weight, then weigh 10 parts of resistant dextrin, pass each raw material through a 100-mesh sieve, mix well, add ethanol with a volume concentration of 75% equivalent to 15% of the total weight, and granulate , dried at 55°C for 3 hours, passed through a 14-mesh sieve for granulation, added mass fraction of 0.5% magnesium stearate, mixed evenly, and pressed into 0.6g / tablet tablets.

[0026] It should be noted that when the purchased corn silk is not in a powder state, it needs to be crushed first and then passed through a 100-mesh sieve.

Embodiment 2

[0028] A composition for daily prevention and treatment of microthrombosis, which is made of the following materials in parts by weight: 30 parts of ground dragon protein, 30 parts of nattokinase, and 10 parts of corn silk. The medicine preparation method of this example is basically the same as that of Example 1, the difference is that the medicine formula is replaced by the formula of this example.

Embodiment 3

[0030] A composition for daily prevention and treatment of microthrombosis, which is made of the following materials in parts by weight: 10 parts of ground dragon protein, 10 parts of nattokinase, and 30 parts of corn silk. The medicine preparation method of this example is basically the same as that of Example 1, the difference is that the medicine formula is replaced by the formula of this example.

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a composition for daily prevention and treatment of microthrombus and application. The composition is prepared from the following substances in parts by weight: earthworm protein, nattokinase and corn stigma in a weight ratio of (3-1): (3-1): (3-1). According to the invention, earthworm protein and nattokinase are utilized to directly dissolve fibrin in microthrombus or indirectly activate other plasmin so as to play a role in prevention and treatment; corn stigma is used for improving the antioxidant capacity of the body, reducing inflammatory factors and enhancing the antithrombotic effect of earthworm protein and nattokinase, and can remarkably dissolve microthrombus, improve old thrombus, reduce blood viscosity and improve the blood microenvironment.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a composition and application for daily prevention and treatment of microthrombosis. Background technique [0002] Microthrombosis is a small vein that occurs in the microcirculation. It is a thrombus in the microcirculation and capillaries, which can only be found under a microscope. In disseminated intravascular coagulation, the coagulation system is activated, and microthrombosis is widely formed in systemic capillaries, leading to ischemic organ dysfunction. Most of these microthrombi are fibrinous thrombi, but they can also be platelet thrombi. After some microthrombosis is formed, the fibrinolytic system is activated, which makes the thrombus leave the place where it was generated and wander in the blood of the whole body. Therefore, thrombus may not be seen in pathological examination. [0003] After the microthrombosis falls off, it flows to the whole b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P7/02A61P9/00A61K36/16A61K36/254A61K36/258A61K36/899A61K38/17
CPCA61K36/16A61K36/254A61K36/258A61K36/899A61K38/1767A61K38/482A61P7/02A61P9/00C12Y304/21062A61K2300/00
Inventor 明磊国张丹王清霞李阿峰
Owner 陕西中鸿科瑞再生医学研究院有限公司
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