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Roxburgh rose active extract with auxiliary protection effect on acute alcoholic liver injury

A technology for alcoholic liver injury and protection, applied in food ingredients containing natural extracts, medical preparations containing active ingredients, applications, etc., can solve problems such as less research on the mechanism

Inactive Publication Date: 2021-04-13
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rosa roxburghii is in auxiliary protection alcoholic liver injury, and prior art discloses that Rosa roxburghii juice or Rosa roxburghii polyphenols can relieve the alcohol and protect the liver of rats with acute alcoholism, and mainly utilize the antioxidant activity of Rosa roxburghii to realize the detoxification effect. The role of wine in protecting the liver, there are few studies on the mechanism of total triterpenoids and total flavonoids in Rosa roxburghii

Method used

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  • Roxburgh rose active extract with auxiliary protection effect on acute alcoholic liver injury
  • Roxburgh rose active extract with auxiliary protection effect on acute alcoholic liver injury
  • Roxburgh rose active extract with auxiliary protection effect on acute alcoholic liver injury

Examples

Experimental program
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Effect test

Embodiment 1

[0030] An active extract of Rosa roxburghii with auxiliary protective effect on acute alcoholic liver injury contains total triterpenes and total flavonoids, wherein the content of total triterpenes is 5% and the content of total flavonoids is 10%.

[0031] The total triterpenoids in the active extract of Rosa roxburghii include Rosic acid, 2-oxopampoulic acid, KajiichigosideF1 and Rosaic acid; the total flavonoids include quercetin, catechin, dihydromyricetin and Ding.

[0032] Wherein the content of the total triterpenoids is the sum of the contents of rosic acid, 2-oxopampoulic acid, Kajiichigoside F1 and prickly acid, and the content of the total flavonoids is quercetin, catechin, dihydromyricetin and aloe The sum of the content of Ding.

[0033] The content of the above-mentioned total triterpenoids is based on ursolic acid as a reference substance, and is obtained by using the vanillin-glacial acetic acid-perchloric acid colorimetric method to measure; the content of the ...

Embodiment 2

[0036] An active extract of Rosa roxburghii with auxiliary protective effect on acute alcoholic liver injury contains total triterpenoids and total flavonoids, wherein the content of total triterpenoids is 10%; the content of total flavonoids is 5.5%.

[0037] The total triterpenoids in the active extract of Rosa roxburghii include Rosic acid, 2-oxopampoulic acid, KajiichigosideF1 and Rosaic acid; the total flavonoids include quercetin, catechin, dihydromyricetin and Ding.

[0038] Wherein the content of the total triterpenoids is the sum of the contents of rosic acid, 2-oxopampoulic acid, Kajiichigoside F1 and prickly acid, and the content of the total flavonoids is quercetin, catechin, dihydromyricetin and aloe The sum of the content of Ding.

[0039] The content of the above-mentioned total triterpenoids is based on ursolic acid as a reference substance, and is obtained by using the vanillin-glacial acetic acid-perchloric acid colorimetric method to measure; the content of...

Embodiment 3

[0042] An active extract of Rosa roxburghii with auxiliary protective effect on acute alcoholic liver injury contains total triterpenoids and total flavonoids, wherein the content of total triterpenoids is 25%; the content of total flavonoids is 3%.

[0043] The total triterpenoids in the active extract of Rosa roxburghii include Rosic acid, 2-oxopampoulic acid, KajiichigosideF1 and Rosaic acid; the total flavonoids include quercetin, catechin, dihydromyricetin and Ding.

[0044] Wherein the content of the total triterpenoids is the sum of the contents of rosic acid, 2-oxopampoulic acid, Kajiichigoside F1 and prickly acid, and the content of the total flavonoids is quercetin, catechin, dihydromyricetin and aloe The sum of the content of Ding.

[0045] The content of the above-mentioned total triterpenoids is based on ursolic acid as a reference substance, and is obtained by using the vanillin-glacial acetic acid-perchloric acid colorimetric method to measure; the content of t...

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Abstract

The invention relates to a roxburgh rose active extract with an auxiliary protection effect on acute alcoholic liver injury. The active extract is prepared by the following steps: performing alcohol reflux extraction on freshly squeezed roxburgh rose pomace or roxburgh rose fruits, filtering, concentrating to remove ethanol, adding water to disperse water insoluble precipitate, filtering, sequentially washing the precipitate with water and petroleum ether or n-hexane, removing water-soluble substances and grease, and drying. The active extract is rich in triterpene and flavone components, has an auxiliary protection effect on acute alcoholic liver injury, can be used for preparing medicines and auxiliary medicines for auxiliary protection of acute alcoholic liver injury or used as a healthy food additive, and has relatively high application value and market prospect. The roxburgh rose extract has important significance in high-value utilization and sustainable development of the rosa roxburghii tratt fruit industry, an intermediate or additive raw material is provided for medicines or health-care foods for auxiliary protection of acute alcoholic liver injury, and the preparation method is simple, easy to implement, low in cost and capable of realizing industrial production.

Description

technical field [0001] The invention relates to an extract of roxburghii fruit or pomace, in particular to an active extract of roxburghii with auxiliary protective effect on acute alcoholic liver injury. Background technique [0002] Prickly pear (Rosaroxbughii Tratt) is a deciduous shrub plant in the family Rosaceae. Rosa roxburghii is known as the "King of Vitamin C", "China's Dengyi Fruit" and "Yanhuang Sacred Fruit". It is a precious fruit resource represented by the third generation of fruit (3G). Rosa roxburghii has been included in the list of new food resources approved by the Health and Health Commission, and is now a common food; the 1994 and 2003 editions of "Quality Standards for Traditional Chinese and National Medicinal Materials in Guizhou Province" include Rosa roxburghii, which has medicinal and medicinal properties. Edible dual attributes. Rosa roxburghii, as a kind of economic crop for food and medicine, is mainly produced in Southwest China, and has be...

Claims

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Application Information

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IPC IPC(8): A61K36/738A23L33/105A61P1/16A61K131/00
CPCA61K36/738A61P1/16A23L33/105A61K2236/333A61K2236/39A61K2236/53A61K2236/51A23V2002/00A23V2200/334A23V2200/32A23V2250/21
Inventor 陈发菊杨小生李良群官志忠高明王瑜李齐激李立郎廖秀葛丽娟杨艳杨娟严艳芳
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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