Optical hypersurface material, application and macromolecular substance transepidermal cell introduction method

A technology of macromolecular substances and epidermal cells, which is applied in the field of macromolecular substances trans-epidermal cell import and optical metasurface materials, which can solve the problems of limited penetration into the dermis, low efficiency, and long treatment cycle.

Inactive Publication Date: 2021-04-23
JIHUA LAB
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Problems solved by technology

However, these three methods have significant disadvantages: the process of oral administration through the digestive system and metabolism to reach the dermis is very complicated and uncontrollable, and can only have a broad nutritional effect from the perspective of nutrition; The liquid is volatile, the ability to penetrate into the dermis is very limited, the efficiency is low, and the treatment cycle is long; the injection method often leads to local drug overdose, which in turn causes side effects of varying degrees

Method used

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  • Optical hypersurface material, application and macromolecular substance transepidermal cell introduction method
  • Optical hypersurface material, application and macromolecular substance transepidermal cell introduction method
  • Optical hypersurface material, application and macromolecular substance transepidermal cell introduction method

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preparation example Construction

[0037] The present invention also proposes a preparation method of an optical metasurface material, please refer to figure 2 ,include:

[0038] A plurality of pointed cone structures are formed by etching on the upper surface of the substrate.

[0039] Specifically, the substrate may be, for example, a silicon wafer, or titanium dioxide or silicon dioxide. The base includes an upper surface and a lower surface oppositely disposed.

[0040] Specifically, a plurality of pointed cone structures are formed by etching on the upper surface of the substrate. The pointed cone structures may be, for example, pyramid-shaped, but not limited thereto, and may also be triangular-conical, conical, or other irregular conical shapes. etc., it is enough to make the pointed cone structure have a point.

[0041] Specifically, the size of the pointed cone structure is on the order of submicron to micron, and is adjusted with reference to the size of the acting cells.

[0042] More specifical...

Embodiment 1

[0076] The preparation process of the optical metasurface material of embodiment 1 is as follows:

[0077] 1. Wet etching forms a pyramid-shaped cone structure on the surface of the silicon wafer

[0078] 1. Using plasma enhanced chemical vapor deposition (PECVD) to deposit a layer of silicon nitride (Si 3 N 4 ) film, after coating, spin coat a layer of photoresist and cover the mask plate, use a photolithography machine for exposure treatment, and obtain a circular Si after development and etching 3 N 4 mask layer;

[0079]2. Then use acetone and deionized water to ultrasonically clean the silicon wafer to remove residual photoresist and ensure the cleanliness of the silicon wafer;

[0080] 3. Finally, carry out alkali etching on the silicon wafer, use the mixed solution of potassium hydroxide, water and isopropanol as the alkali etching solution, and carry out alkali etching on the silicon wafer. Based on the principle of anisotropic etching, by controlling the etching ...

Embodiment 2

[0084] The difference between the optical metasurface material of Example 2 and Example 1 is that the metal plated on the surface of the conical structure is not gold, but silver-plated, and the other steps are the same as in Example 1, and will not be repeated here.

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Abstract

The invention provides an optical hypersurface material. The optical hypersurface material comprises a substrate which comprises an upper surface and a lower surface, a hypersurface structure which is formed on a plurality of pointed cone structures formed on the upper surface of the substrate, and a metal coating which is formed through a metal coating layer on the surfaces of the pointed cone structures. A tip covered with metal serves as a near-field source, the tip (needle tip) enhancement effect generates a highly-enhanced and localized electric field, and reversible electroporation is generated on a cell membrane, so that the permeability of the cell membrane is improved, and the introduction capacity of macromolecular substances is improved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an optical metasurface material, its use and a method for introducing macromolecular substances across epidermal cells. Background technique [0002] Precision medicine drug delivery is one of the fastest-growing technologies in the field of precision medicine. Its goal is to solve the problem that traditional drug delivery technology cannot "precisely" deliver drugs to diseased cells. The latest technological achievements in this field, such as "smart nano-drug loading", can control the drug concentration and local temperature across cells through fixed-point, timing and quantitative control of near-infrared laser under the guidance of fluorescence images, and precisely control the release of chemotherapy drugs. Precise drug delivery to diseased tissues can effectively control the release environment of drugs and greatly reduce the damage of drugs to other body tissues. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K41/00A61K47/02A61K38/18B82Y5/00
CPCA61K9/0009A61K9/06A61K38/18A61K41/0023A61K47/02B82Y5/00A61K2300/00
Inventor 毕海宋小贤吴子祺梁洁王悦
Owner JIHUA LAB
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