66results about "Agression altered materials" patented technology

A method for reversibly, or irreversibly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with devices for monitoring and / or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and / or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cells or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.

Embodiments of the present invention relate to methods and pharmacological compositions to treat presbyopia in the human eye. According to the embodiments, pharmacological compositions may be applied to an eye to effect a change in the accommodative ability of the eye by the breaking and reduction of lenticular bonds in the eye that may be responsible for presbyopia. The compositions may be applied in an inactive state and subsequently be activated to achieve a therapeutic effect.

Cancer cells can be synchronized to the G2 / M phase by delivering an anti-microtubule agent (e.g., paclitaxel or another taxane) to the cancer cells, and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells, wherein at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. This synchronization can be taken advantage of by treating the cancer cells with radiation therapy after the combined action of the delivering step and the applying step has increased a proportion of cancer cells that are in the G2 / M phase. The optimal frequency and field strength will depend on the particular type of cancer cell being treated. For certain cancers, this frequency will be between 125 and 250 kHz (e.g., 200 kHz) and the field strength will be at least 1 V / cm.

The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.

A method of treating a disease characterized by a pathological immune response in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a cell preparation which comprises dying or dead leukocytes, the dying or dead leukocytes being capable of suppressing the pathological immune response, thereby treating the disease in the subject.

Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in vivo or in vitro environments).

This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and / or by applying energy to affect a change in the accommodative abilities of the human lens. This invention both prevents the onset of presbyopia as well as treats it. By breaking and / or preventing the formation of bonds that adhere lens fibers together causing hardening of the lens, the present invention increases the elasticity and distensibility of the lens and / or lens capsule.

The present invention provides the use and composition of matter of angiogenic or other growth / cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and stages of differentiation. Also provided are unencapsulated preparations (mixed with or applied to extracellular matrix material or synthetic biocompatible substances) for the purpose of temporary application to wounds or defects in the skin or other tissues for the restoration of blood supplying connective tissue to enable organ-specific cells to reestablish organ integrity as well as to inhibit excessive scar formation.

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and / or by applying energy to affect a change in the accommodative abilities of the human lens. This invention both prevents the onset of presbyopia as well as treats it. By breaking and / or preventing the formation of bonds that adhere lens fibers together causing hardening of the lens, the present invention increases the elasticity and distensibility of the lens and / or lens capsule.

The invention discloses an application of a carbon quantum dot-graphite phase like carbon nitride photocatalytic material to preparation of medicines capable of killing bacteria and promoting skin cicatrice healing. A preparation method of the material comprises the following steps of placing urea at the temperature of 500-600 DEG C for calcination so as to obtain graphite phase carbon nitride powder; enabling citric acid and ethylenediamine to dissolve in water, performing a hydrothermal synthesis reaction at 180-200 DEG C, performing cooling, and performing drying so as to obtain carbon quantum dot powder; and mixing the carbon quantum dot powder with water, adding the graphite phase carbon nitride powder to mixed liquor, performing stirring and macerating at the temperature of 15-60 DEGC for 12-24 hours, and performing drying so as to obtain the catalysis material. According to the application disclosed by the invention, an in vitro staphylococcus aureus infection model and an in vitro staphylococcus aureus infection model are constructed, the inventor finds that the carbon quantum dot-graphite phase like carbon nitride photocatalytic material prepared by a specific method hasmore photocatalytic reaction active sites, is higher in photocatalytic activity and is obvious in the effect of killing staphylococcus aureus.

Cancer cells can be synchronized to the G2 / M phase by delivering an anti-microtubule agent (e.g., paclitaxel or another taxane) to the cancer cells, and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells, wherein at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. This synchronization can be taken advantage of by treating the cancer cells with radiation therapy after the combined action of the delivering step and the applying step has increased a proportion of cancer cells that are in the G2 / M phase. The optimal frequency and field strength will depend on the particular type of cancer cell being treated. For certain cancers, this frequency will be between 125 and 250 kHz (e.g., 200 kHz) and the field strength will be at least 1 V / cm.

A method for reversibly, or irreversibly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is provided. The acoustic energy is applied indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and / or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials. In the preferred embodiment, the method includes applying the ultrasound in combination with devices for monitoring and / or implementing feedback controls.

The present disclosure generally relates to methods, devices and systems relating to applying drugs or therapeutic agents to biological conduits, e.g., vascular lumens. More specifically, the present invention comprises enhancing the uptake of drugs or therapeutic agents encapsulated in microbubbles in combination with ultrasound energy as well as applying drugs or therapeutic agents in a cyclic manner using a pulse generator that may be matched in frequency with a patient's blood pulsing.

A method for activating particles for internal radiopharmaceutical use, said particles comprising precursor nuclides to be activated, is disclosed. The method comprises: directing a high-intensity laser beam onto converting means to produce an irradiating field; and irradiating said particles comprising precursor nuclides in said irradiating field to activate said precursor nuclides, thereby obtaining radiolabeled particles.

Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual.

There is provided a combination treatment for slowing or arresting the progression and / or effecting the regression of atherosclerotic plaque deposits in a mammalian patient, said combination treatment including the administration to the patient of a cholesterol lowering drug such as a statin, and the administration to the patient of an aliquot of a patient's own blood which has been treated ex vivo with one or more stressors selected from an oxidative environment, thermal stress and UV light.

Methods for administering nitric oxide (NO) in a plasma state to a treatment site are disclosed. A discrete stream of matter is placed in a plasma state, in which the stream has, as part of its content, a desired concentration of NO. The discrete stream of matter is directed at a site of action to achieve a therapeutic result.

The present invention provides a system for imparting electromagnetic energy into drinking water or aqueous potables and foods, comprising: a generator unit for generating a driving signal having a frequency to maintain a nature or an activity of microorganisms in living forms; a power supply unit for providing a voltage current to the generator unit to drive the generation of the driving signal; one or more inductor coils coupled to the generator unit to receive the driving signal, such that an electromagnetic field operating with the varying frequency is generated; and an electromagnetic wave-permeable container for containing the drinking water or the aqueous potables and foods wherein the drinking water or the aqueous potables and foods is subject to the generated electromagnetic field to allow permeation of the varying frequency electromagnetic wave through the container into the drinking water or the aqueous potables and foods to acquire electromagnetic energy. The invention also provides a method for imparting electromagnetic energy into drinking water or aqueous potables and foods.

A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

A method of inhibiting growth of, reducing or eliminating a cell population of a subject in need thereof is disclosed. The method comprises (a) thermally, mechanically and / or chemically damaging antigen-bearing cells which comprise at least one antigen characterizing cells of the cell population, with the proviso that the chemically damaging of the antigen-bearing cells is not predominantly effected using one or more antineoplastic agents, thereby generating immunogenic cells; and (b) introducing in the subject a cell aggregate which comprises the immunogenic cells and added antigen-presenting cells, thereby inducing an immune response for inhibiting growth of, reducing or eliminating the cell population of the subject.

Disclosed herein is a method for regenerating retinal tissue which includes preparing a luminescent scaffold, implanting the luminescent scaffold in a portion of retina, for example subretinal area, emitting a green light from the luminescent nanoparticles in a luminescence phenomenon, and absorbing the emitted light by retinal cells for regenerating retinal tissue by stimulating the retinal cells. Moreover, preparing a luminescent scaffold may comprise synthesizing a plurality of luminescent particles, dispersing the luminescent particles in a polymeric matrix to form a luminescent composite, and electrospinning the luminescent composite to form the luminescent scaffold.

This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.

The invention relates to medicine-carrying nano particles transmitting the blood brain barrier and cooperating with a focused ultrasonic targeted micro-bubble damage technology for assisting a chemotherapeutic drug curcumin in transmitting the blood brain barrier and relates to a preparation method and effective parameters of a drug conveying system and application of the drug conveying system intreatment for the neurodegenerative disease. The schematic diagram of the medicine-carrying nano particles transmitting the blood brain barrier and cooperating with the focused ultrasonic targeted micro-bubble damage technology is shown in the description, carrier components comprise organic / inorganic compound lipid and polysorbate 80, the proportion can be regulated and controlled according to the demands, the medicine-carrying amount is increased, the plasma half-life is prolonged, and the efficiency of transmitting the blood brain barrier is improved. Under the function of the focused ultrasonic targeted micro-bubble damage, through the nano particles, the curcumin can be gathered and taken in the specific brain area through a fixed-point and targeted method, and the treatment effect ofthe chemotherapy on the neurodegenerative disease is effectively improved.

Mammalian disorders associated with a deficiency in the cytokine interleukin-10 (IL-10) can be alleviated by stimulating in vivo secretion and / or activity of IL-10 in the patient's blood or tissues by application of external stimulus.

Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and / or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and / or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and / or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

The rotating machine comprises a shaft (14), a casing (12), at least one main magnetic bearing connected to the shaft for rotatably supporting said shaft inside the casing, at least one first and one second auxiliary rolling bearings (20, 22) positioned between the shaft and the casing to support axial and radial loads, and first and second axial abutment means (44, 54) positioned on the shaft to transmit axial loads to inner rings of the rolling bearings. The machine further comprises a spacer (28) axially positioned between facing faces of the inner rings (20a, 22a) of said rolling bearings for the transmission of the axial loads between said inner rings, and at least a first axial retaining means (58) positioned on the casing and located axially between facing faces of the outer rings (20b, 22b) for the transmission of the axial loads between at least one of said outer rings and the casing.