104results about "Agression altered materials" patented technology

Provided are methods, compositions, and kits for improving a delivery of a nucleic acid to a cell in an organ of a subject. Such methods, compositions, and kits may include a sonoactive agent and a nucleic acid comprising a cargo polynucleotide and a nuclear localization element and / or an innate immune response avoidance moiety, which may be an aptamer. Delivery may involve sonoporation.

The invention provides piezoelectric hydrogel for improving the delivery survival rate of stem cells as well as a preparation method and application of the piezoelectric hydrogel, and belongs to the technical field of biological medicines. The invention provides an electric protection strategy, the plasma membrane of the stem cell is protected in the transplantation process, and an endogenous repair mechanism after stress-induced damage is started. Wherein barium titanate (BTO) nanoparticles with piezoelectric characteristics are encapsulated in RGD polypeptide modified oxidized sodium alginate / adipic dihydrazide modified hyaluronic acid hydrogel, and the injectable hydrogel with an electric protection effect is constructed and is used for delivering the BMSCs. By increasing the concentration of free calcium in cells and starting endogenous membrane repair to re-close damaged membranes, the resistance of stem cells to abnormal stress is enhanced, and instant anti-damage protection is provided for cells. The survival rate of the stem cells in the transfer process is remarkably improved by the piezoelectric hydrogel with electric protection, and the piezoelectric hydrogel has a relatively great application prospect in treatment of intervertebral disc degeneration diseases.

The invention relates to a preparation method of an efficient antibacterial material based on bionic design. The method comprises the following steps: step A, synthesizing a piezoelectric antibacterial material; and step B, combining the piezoelectric antibacterial material and a targeting material through a liposome carrier to prepare a bionic bacteriophage. According to the scheme, an innovative bionic bacteriophage concept is provided, a simple and intelligent antibacterial system is developed, reactive oxygen species (ROS) in a bacterial microenvironment is stimulated to be improved through energy conversion, bacterial cell membranes, protein and DNA are destroyed, and therefore antibacterial treatment is carried out.

The invention provides bismuth oxyiodate composite piezoelectric hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel materials. The bismuth oxyiodate composite piezoelectric hydrogel disclosed by the invention is prepared from the following raw materials in percentage by mass: 0.125 percent to 0.5 percent of first self-assembled oligopeptide, 0.125 percent to 0.5 percent of self-assembled stem cell bone marrow homing peptide, 0 to 0.02 percent of BiOIO3 nanosheets and 98.99 percent to 99.75 percent of a solvent. BiOIO3NSs are integrated into self-assembled stem cell bone marrow homing peptide, the injectable and degradable piezoelectric hydrogel with ultrasonic responsiveness is constructed, BiOIO3NSs shows remarkable piezoelectric catalysis performance, generation of active oxygen is promoted, tumor cell apoptosis is induced, and the piezoelectric hydrogel has the advantages of being capable of being used for preparing the bone marrow homing peptide, capable of being used for preparing the bone marrow homing peptide and capable of being used for preparing the bone marrow homing peptide. The bismuth oxyiodate composite piezoelectric hydrogel disclosed by the invention is a biological material capable of inhibiting the growth and recurrence of tumors and recovering the structure and function of bones to the greatest extent.

The present invention relates to methods of producing microbubble drug conjugates, viral gene therapy microbubble drug conjugates, and disease-targeting microbubbles, for clinical and preclinical ultrasound-mediated therapeutic and diagnostic applications. It includes methods to produce viral vector gene therapy microbubble drug conjugates with antibody linkers conjugated to lipid shelled microbubbles that both bind to and neutralize viral vectors such that the viral gene therapy can transduce and effect permanent genetic changes only after ultrasound is used to disassociate the viral gene therapy from microbubbles at diseased regions of the body.

Provided herein are self-assembling collagen-like peptide (CLP) comprising a plurality of amino acid trimer repeats having the amino acid sequence POG, wherein P is a proline, O is an hydroxyproline or a cysteine, and G is a glycine or a valine. Also provided herein are compositions, scaffolds, photoactivatable hydrogel precursors and hydrogels comprising the CLP and a multi-arm polyethylene glycol (PEG) polymer. Methods of preparing photoactivatable hydrogel precursors and hydrogels are also described. Methods of treating a wound, of treating a corneal disease, of treating a myocardial infarct, of promoting cell growth and of treating cellular degeneration using the compositions, scaffolds, photoactivatable hydrogel precursors and / or hydrogels are also described. Also provided is a device for delivering a peptide-based material. The device comprises an on / off button or switch for initiating and stopping delivery of the peptide-based material in the subject; a chamber for containing the peptide-based material; an aperture through which the peptide-based material exits the chamber, wherein the aperture is adapted for receiving a nozzle adapter; a camera port for securing a camera thereto; and a digital control display.

A yeast cell for use in the treatment and / or alleviation of allergy and / or symptoms caused by allergy, wherein the yeast cell has been treated with electromagnetic waves in the range of 1 GHz to 300 GHz, or said yeast cell has been grown from a yeast cell treated with electromagnetic waves in the range of 1 GHz to 300 GHz, and composition comprising such a yeast cell.

The invention discloses a preparation method of a piezoelectric MOF (Metal Organic Framework) sound-sensitive agent with an ultrasonic response ROS / CO synergistic antibacterial function. The preparation method comprises the following steps: synthesizing a catechol modified ruthenium carbonyl carbon monoxide donor through a coupling reaction of 2, 4-dihydroxyl-1-phenylalanine and carbonyl ruthenium chloride; the preparation method comprises the following steps: mixing a carnosine aqueous solution and a metal ion aqueous solution in a solvent, and self-assembling the carnosine aqueous solution and the metal ion aqueous solution by a hydrothermal method to obtain a piezoelectric metal organic framework (PMOF); and modifying the carbon monoxide donor on the surface of the PMOF through a complexation reaction between metal ions on the surface of the PMOF and phenolic hydroxyl groups of the carbon monoxide donor to obtain the piezoelectric MOF sound-sensitive agent with ultrasonic response ROS / CO synergistic antibiosis. The invention also discloses the piezoelectric MOF sonosensitizer with ultrasonic response ROS / CO synergistic antibacterial effect obtained by the preparation method and application of the piezoelectric MOF sonosensitizer in preparation of sonosensitizer hydrophobic drugs and / or antibacterial agents. The sonosensitizer provided by the invention has excellent biocompatibility, can controllably start release of active oxygen and carbon monoxide through ultrasound to achieve synergistic antibiosis, enhances the antibacterial ability, and has excellent biological membrane penetrating ability.

Disclosed herein are nucleic acid compositions and methods of use. The nucleic acid compositions may have a therapeutic nucleic acid sequence operably linked to a nuclear targeting sequence that increases expression of the therapeutic nucleic acid in a cell by at least 1.25 fold; at least 80% sequence identity to SEQ ID NO: 6; or a first regulatory element comprising a promoter sequence operably linked to a hemoglobin subunit gamma intron (hBGi) sequence, and a second regulatory element comprising a woodchuck hepatitis posttranscriptional regulatory element (WPRE) sequence. The nucleic acid compositions with these features may enhance therapeutic nucleic acid transfection and expression. Also disclosed herein are transgenes optimized for gene therapy applications, including novel FVIII transgene sequences, in which the B domain may be non-naturally occurring the A1 and / or A3 domain may include at least one amino acid substitution.

The present disclosure relates to the field of pharmaceuticals, and particularly, to a method for preparing a tumor vaccine by using magnetic hyperthermia inactivation technology. Firstly, a magnetic hyperthermia therapeutic agent is used to generate magnetic heat in tumor cells to induce immunogenic death of the tumor cells. Secondly, the exogenous substance, the magnetic hyperthermia therapeutic agent, is removed by means of magnetic separation technology. Thirdly, two different strategies may be adopted according to needs: one is to add an immunologic adjuvant to prepare a whole-cell tumor vaccine containing various tumor antigens; the other one is to select a specific tumor neoantigen and add the immunologic adjuvant to prepare a tumor neoantigen vaccine with higher specificity. In a mouse tumor vaccine test, the results show that the whole-cell tumor vaccine prepared by the described method can effectively inhibit the growth of homologous tumors, and the tumor-free rate of mice in the vaccination group reached 100%. Thus, the present disclosure provides a new treatment strategy for clinical anti-tumor immunotherapy and possesses good application prospects.

The invention relates to an ultrasonic response bionic piezoelectric nano-drug for treating epilepsy as well as a preparation method and application of the ultrasonic response bionic piezoelectric nano-drug. The ultrasonic response bionic piezoelectric nano-drug comprises hafnium-based piezoelectric nano-particles UIO-66-NH2 etched by sulfuric acid, an anti-epileptic drug, a microglial cell membrane and transferrin receptor targeting peptide, wherein the anti-epileptic drug is loaded in hafnium-based piezoelectric nanoparticles etched by sulfuric acid to form a drug loading core; the microcolloid cell membrane coats the outer surface of the drug loading core; the transferrin receptor targeting peptide is connected to a microglial cell membrane. The ultrasonic response bionic piezoelectric nano-drug is high in brain entering efficiency, stable in drug release amount and clear in preparation method path, is suitable for targeted delivery of various anti-epileptic drugs and treatment and research of nervous system diseases such as epilepsy, can adopt an intravenous injection administration mode and non-invasive administration, can avoid injury caused by an operation, and has a good application prospect. The electrical stimulation is generated in vivo without implanting and taking out the electrode, so that secondary injury and infection are avoided.

Methods for enhancing intracellular uptake of active agents by inducing temporary pore formation in a cell membrane are described. The methods generally comprise introducing nanoparticles to a cell in vivo, ex vivo, or in cell culture to magnetic nanoparticles that are taken up into the cell interior. The methods further comprise introducing active agents to the cell. A magnetic field is applied to the cell for targeted excitation of the internalized magnetic nanoparticles to induce temporary pore formation in the cell membrane, such that the active agent is taken up in an increased amount and / or at an increased rate by the cell.

A pharmaceutical composition comprising a microbubble / microdroplet cluster composition for use in a method of treatment of diseases, disorders, or injuries of the central nervous system (CNS) is provi

The present invention relates to optimized microbubbles that can be used in the prevention and treatment of diseases or for marking, in particular, lipid microbubbles. The present invention relates in particular to lipid microbubbles comprising at least one cationic compound selected from lipophosphoramidates, histidyl polyethyleneimine, and any mixture thereof. The microbubbles preferably further comprise at least one agent selected from therapeutic agents, targeting agents, marking agents, and any combination thereof. The present invention further relates to a method for producing such microbubbles. The present invention further relates to a composition, in particular a pharmaceutical composition, and a kit comprising at least one of these microbubbles. The present invention further relates to the use of these microbubbles, compositions, kits as pharmaceuticals or marking agents.

The invention belongs to the technical field of medicines, and relates to injectable piezoelectric hydrogel for a spinal cord injury part as well as a preparation method and application of the injectable piezoelectric hydrogel. According to the hydrogel, methacrylated gelatin is used as a carrier, and a piezoelectric material MOF (at) PDA (at) M0, namely MP (at) M, of an enveloping porous structure is loaded in the hydrogel. The hydrogel can achieve dual functions under the ultrasonic action: (1) MP (at) M has piezoelectricity, ultrasonic mechanical energy is converted into electrical stimulation, calcium ion inward flow of astrocytes is triggered, mitochondria is promoted to be transferred from the astrocytes to neurons, and the mitochondrial function of the neurons is recovered; (2) the CD73 enzyme carried by the microglial cell membrane coated on the surface of the MP (at) M can degrade pro-inflammatory ATP (adenosine triphosphate) at the damaged part to generate adenosine, so that astrocytes are promoted to release lactic acid, and rapid energy support is provided for neurons. Mitochondrial transfer and energy supply are synchronously promoted through ultrasonic stimulation, neuronal plasticity is remodeled, spinal cord axon regeneration is promoted, and a new strategy is provided for spinal cord injury treatment.

The invention discloses a piezoelectric nanomaterial for triggering mitochondrial fusion and a preparation method and application thereof, and belongs to the technical field of biology, and the piezoelectric nanomaterial provided by the invention can supplement electron depolarization mitochondrial membrane potential (delta psi) in a targeted manner under ultrasonic stimulation. The depolarization of the delta psi significantly promotes the mitochondrial fusion and inhibits the fission of the mitochondrial by activating mechanisms such as long optic nerve atrophy 1 (OPA1) and calcium ion influx, so that mitochondrial fusion proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are activated, the recruitment of dynamic protein related protein 1 (Drp1) is inhibited, the expression of mitochondrial fission protein 1 (Fis1) is reduced, and a JC-1 dye evaluates the delta psi, so that the depolarization of the delta psi is realized. The observed mitochondrial dynamic change is in positive correlation, the mitochondrial fusion is regulated by using the nano material, and a new method is provided for targeting tumor metabolism and improving cancer treatment results.

The invention discloses a preparation method of a piezoelectric MOF (Metal Organic Framework) sound-sensitive agent with an ultrasonic response ROS / CO synergistic antibacterial function. The preparation method comprises the following steps: synthesizing a catechol modified ruthenium carbonyl carbon monoxide donor through a coupling reaction of 3, 4-dihydroxyl-1-phenylalanine and carbonyl ruthenium chloride; the method comprises the following steps: mixing an L-carnosine aqueous solution and a zinc ion aqueous solution in a solvent, and self-assembling the two solutions by a hydrothermal method to obtain a piezoelectric metal organic framework (PMOF); and modifying the carbon monoxide donor on the surface of the PMOF through a complexation reaction between zinc ions on the surface of the PMOF and phenolic hydroxyl groups of the carbon monoxide donor to obtain the piezoelectric MOF sound-sensitive agent with ultrasonic response ROS / CO synergistic antibiosis. The invention also discloses the piezoelectric MOF sonosensitizer with ultrasonic response ROS / CO synergistic antibacterial effect obtained by the preparation method and application of the piezoelectric MOF sonosensitizer in preparation of sonosensitizer hydrophobic drugs and / or antibacterial agents. The sonosensitizer provided by the invention has excellent biocompatibility, can controllably start release of active oxygen and carbon monoxide through ultrasound to achieve synergistic antibiosis, enhances the antibacterial ability, and has excellent biological membrane penetrating ability.

The present disclosure includes a system for treating cancer, the system comprising: an extracorporeal circulation device that is for collecting and returning the blood of a subject, and that includes a blood circuit and a blood pump; and a light irradiation device that is for irradiating the blood circuit with light. A photosensitive substance is administered to the subject before blood collection or is added, before light irradiation, to blood collected from the subject. The blood that has been collected from the subject and has been irradiated with light is returned to the subject. The irradiation energy density of the light is 2.5-300 J / cm2.

The present invention discloses a micellar mixed system for enhancing the therapeutic effect of irreversible electroporation on pancreatic cancer and a preparation method thereof. By mixing CGP37157-loaded PEG-PCL micelles (CGP37157@PEG-PCL) with a CaCl2 solution to form an injectable micellar mixed system, the poorly water-soluble CGP37157 sodium-calcium exchange inhibitor can be delivered into tumor cells. During electroporation therapy, as the permeability of tumor cells increases, the excretion of calcium ions in mitochondria is inhibited, further leading to mitochondrial calcium overload and accelerating tumor cell death. This can effectively improve the efficiency of IRE treatment and has good clinical application prospects.

The invention relates to the technical field of biology, in particular to acoustoelectric Ba0. 85Ca0. 15Ti0. 9Yb0. 1O3 nanoparticles capable of triggering post-translational modification as well as a preparation method and application of the acoustoelectric Ba0. 85Ca0. 15Ti0. 9Yb0.1 O3 nanoparticles. Stirring and mixing the titanium tetrachloride solution and the mixed reagent solution to obtain a stirred mixed solution; mixing the stirred mixed solution with sodium hydroxide and polyvinylpyrrolidone, and performing heat treatment to obtain a heat-treated substance; and carrying out solid-liquid separation on the heat-treated substance to obtain a solid, washing the solid to be neutral, and drying. The nanoparticles provided by the invention consume H < + > near mitochondria under ultrasonic stimulation, so that mitochondrial membrane potential depolarization is caused. After mitochondrial membrane potential depolarization, E3 ubiquitin ligase Parkin is transferred from cytoplasm to a mitochondrial outer membrane, and is massively gathered and accumulated on the mitochondrial outer membrane, so that ubiquitination modification and cascade degradation of mitochondrial outer membrane anti-apoptosis protein MCL-1 are caused, and cell apoptosis is promoted.

The invention discloses preparation and application of a novel ultrasonic-driven nano-enzyme MOF (Hf)-Pt, the novel piezoelectric nano-enzyme MOF (Hf)-Pt is composed of UIO-66-NH2 (Hf) and an ultra-small Pt nano-enzyme and presents a regular octahedron shape, and the diameter of the novel piezoelectric nano-enzyme MOF (Hf)-Pt is 180-200 nm; the piezoelectric effect is achieved, external ultrasonic stimulation is utilized, and variable electrical stimulation is provided through piezoelectric catalysis; in addition, the composite material has the advantages of being small in size and easy to prepare, has catalase-like activity and superoxide dismutase activity at the same time, and has good biocompatibility. The MOF (Hf)-Pt is used as a novel piezoelectric catalyst, and the technical effect of treating OA is achieved by improving the enzyme catalytic activity of the nano-enzyme, relieving oxygen deficit of an inflammation part, recovering the mitochondrial function, removing excessive ROS in an inflammation tissue and promoting cartilage regeneration through the piezoelectric effect.

The invention discloses a zinc oxide nanosheet and a preparation method and application thereof. The zinc oxide nanosheet is of an ultrathin sheet structure with the thickness of 3-6 nm and has piezoelectric catalytic activity. The preparation method comprises the following steps: dissolving zinc salt and hexamethylenetetramine in a high-volume-fraction ethanol water solution, and stirring at 55-65 DEG C for reaction. The nanosheet is applied to preparation of drugs for destroying bacterial biofilms or treating implant-related infections, and needs to be combined with ultrasonic irradiation. Under the ultrasonic action, the nanosheets generate a piezoelectric catalytic effect, lactic acid in a biological membrane microenvironment can be degraded, immunosuppression is relieved, and macrophages are promoted to be polarized to a pro-inflammatory phenotype; meanwhile, an ultrasonic cavitation effect is combined, so that a biological membrane can be synergistically and efficiently removed and bacteria can be killed.

The invention discloses a magnesium-manganese doped vacancy bismuth oxide nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving NaBiO3 and NaOH in deionized water, adding soluble magnesium salt and soluble manganese salt, stirring at room temperature, transferring the formed suspension solution into a reaction kettle, heating, reacting, separating, washing and drying the reaction product to obtain magnesium-manganese doped vacancy bismuth oxide, dispersing the magnesium-manganese doped vacancy bismuth oxide in a mixed solution of deionized water and ethanol, and ultrasonically crushing with ice water to obtain the magnesium-manganese doped vacancy bismuth oxide. Centrifuging, taking supernatant, centrifuging again, taking precipitate, washing, and drying to obtain a finished product. The MMBOx is synthesized by adopting a one-step hydrothermal method, the method is efficient and simple, the ROS programmable capability is achieved, the sonodynamic / enzymatic activity is improved through the piezoelectric effect and oxygen vacancy doping to promote ROS generation, meanwhile, the ROS is lowered through cascade catalytic enzyme activity, Mg < 2 + > is slowly released to promote tissue repair, the inflammation microenvironment is improved, and the method is particularly suitable for tissue infection repair.

The invention belongs to the technical field of biomedical materials, and particularly relates to ultrasonic-excited piezoelectric delivery exosome electrostatic spinning and a preparation method thereof.The piezoelectric delivery exosome electrostatic spinning comprises piezoelectric electrostatic spinning prepared by embedding barium titanate nanoparticles into polylactic acid, the surface of the piezoelectric electrostatic spinning is modified by chitosan and then loaded with exosome, and the surface of the piezoelectric electrostatic spinning is loaded with the exosome. The preparation method comprises the following steps: preparation of piezoelectric electrostatic spinning: dissolving polylactic acid in hexafluoroisopropanol, adding barium titanate nanoparticles, and carrying out ultrasonic dispersion to form a uniform precursor solution; piezoelectric electrostatic spinning containing barium titanate is prepared through high-voltage electrostatic spinning; piezoelectric electrostatic spinning surface modification: immersing the piezoelectric electrostatic spinning into a chitosan solution for incubation, and modifying the piezoelectric electrostatic spinning to form piezoelectric electrostatic spinning with positive electricity on the surface; the modified piezoelectric electrostatic spinning is soaked in an exosome suspension to be incubated, and piezoelectric exosome delivery electrostatic spinning is prepared and has the self-energy-supply function, the space-time response function and the biological delivery function, the defects of traditional biological medicine materials are hopefully overcome, and the piezoelectric exosome delivery electrostatic spinning can be applied to the field of biological medicine materials. The clinical transformation application of the intelligent biological material in the chronic wound repair of diabetes mellitus is promoted.

The invention discloses efficient tumor sonodynamic therapy nanoparticles based on carbon-doped nano-zinc oxide as well as a preparation method and application of the efficient tumor sonodynamic therapy nanoparticles. Belongs to the field of biomedicine. On the basis of MOF-5, carbon-doped hollow-hole-shaped nano-particles C-ZnO are formed after calcination in a nitrogen atmosphere, then chloroplatinic acid hexahydrate and sodium borohydride are added into a C-ZnO nano-particle solution, so that Pt nano-particles are loaded on the surface of C-ZnO, in addition, AB is loaded in a CZP hollow structure, HA-AA modification is carried out on the surface of the CZP hollow structure, and the CZP hollow structure loaded with the AB is obtained. Therefore, the effects of hydrogen treatment, consumption of excessive glutathione in a biological microenvironment and targeting are achieved, and the effect of treating cancers is achieved from multiple aspects. The nano particles are uniform in size, the average particle size is about 200 nm, good biocompatibility is achieved, and the material prepared through the method has excellent ROS generation capacity, so that the material has excellent sonodynamic therapy potential and has wide application prospects in the field of tumor therapy.

Disclosed herein are nucleic acid compositions and methods of use. The nucleic acid compositions may have a therapeutic nucleic acid sequence operably linked to a nuclear targeting sequence that increases expression of the therapeutic nucleic acid in a cell by at least 1.25 fold; at least 80% sequence identity to SEQ ID NO: 6; or a first regulatory element comprising a promoter sequence operably linked to a hemoglobin subunit gamma intron (hBGi) sequence, and a second regulatory element comprising a woodchuck hepatitis posttranscriptional regulatory element (WPRE) sequence. The nucleic acid compositions with these features may enhance therapeutic nucleic acid transfection and expression. Also disclosed herein are transgenes optimized for gene therapy applications, including novel FVIII transgene sequences, in which the B domain may be non-naturally occurring the A1 and / or A3 domain may include at least one amino acid substitution.

The invention discloses a hybrid membrane coated BCZT nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical treatment. The preparation method of the hybrid membrane coated BCZT nano material comprises the following steps: preparing a BCZT piezoelectric nano material; preparing hybrid membrane vesicles; and uniformly coating the hybrid membrane vesicles on the surface of the BCZT piezoelectric nano material by using a liposome extruder and an ultrasonic dispersion instrument to obtain the hybrid membrane coated BCZT nano material. The BCZT nano material disclosed by the invention can efficiently generate reactive oxygen species (ROS) under ultrasonic catalysis, has a killing effect on bacteria, has very strong tissue penetrability, and can go deep into infected parts to realize an effective antibacterial effect. And finally, the BCZT material is wrapped by a hybrid membrane wrapping technology, so that the stability and biocompatibility of the nano material can be improved, the nano material is more stable in an in-vivo environment, and possible side effects are reduced.

Systems and methods for inducing apoptosis and treating or reducing the onset of at least one condition, disease, disorder or infection in a subject are disclosed. The systems and methods rely on the application of an alternating electric field and the administration of a clustered regular spaced short palindromic repeat (CRISPR)-associated protein (CRISPR-Cas) system. Kits for performing the methods disclosed herein are also provided.

The invention relates to an ultrasound-driven nerve regulation nano device for non-invasive treatment of epilepsy as well as a preparation method and application of the ultrasound-driven nerve regulation nano device. The ultrasound-driven nerve regulation nano device comprises a microenvironment response module, an ultrasound response module and a biological targeting module, the microenvironment response module is platinum nanoparticles, the ultrasonic response module is piezoelectric nanoparticles UIO-66-NH2, and the biological targeting module is brain targeting peptide; wherein the platinum nanoparticles are dispersed and embedded in a UIO-66-NH2 structure, and the brain-targeted peptide is modified on the surface of the UIO-66-NH2 structure. The nano device can effectively decompose hydrogen peroxide in an epilepsy focus area and reduce the oxidative stress level; the mechanical stress can be converted into an electric signal under the ultrasonic action to trigger neuron electrophysiological reaction, so that noninvasive precise regulation and control of an epilepsy reactive neural circuit are realized; meanwhile, the blood brain barrier can be efficiently traversed, and the cumulant of the epilepsy focus part in the brain is obviously enhanced through the synergistic effect of the external field ultrasound and the biological targeting module.

The invention discloses piezoelectric chewing gum with antibacterial and whitening effects and a preparation method of the piezoelectric chewing gum, and belongs to the technical field of pharmaceutical preparations. The piezoelectric chewing gum with antibacterial and whitening effects comprises the following raw materials in parts by weight: 80-120 parts of an edible gum base, 10-30 parts of a sweetening agent, 5-10 parts of saccharides, 10-30 parts of L-polylactic acid fibers, 1-10 parts of chitosan and 1-10 parts of gelatin. The piezoelectric chewing gum is prepared from the L-polylactic acid fiber with piezoelectric property, and the ROS generated by chewing the chewing gum in the oral cavity is combined with a hydrogel system formed by the chitosan and the gelatin and the spectral antibacterial property of the chitosan, so that complete and comprehensive whitening and effective and safe sterilization of teeth are realized; the problems that an existing tooth whitening method damages teeth, the effect is limited, daily use is not convenient and the like are solved, and the application prospect is wide.