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Chitosan-graphene oxide composite gel and preparation method thereof

A graphene composite and chitosan technology, applied in the field of materials, can solve problems such as incomplete classification, and achieve good self-healing properties, good mechanical properties, and stable structures

Inactive Publication Date: 2021-04-27
BEIJING INSTITUTE OF GRAPHIC COMMUNICATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the case of chitosan hydrogels, this classification is not entirely appropriate

Method used

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  • Chitosan-graphene oxide composite gel and preparation method thereof
  • Chitosan-graphene oxide composite gel and preparation method thereof
  • Chitosan-graphene oxide composite gel and preparation method thereof

Examples

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Embodiment 1

[0036] A preparation method of chitosan-graphene oxide composite gel, comprising the following steps:

[0037] S1, at room temperature, take by weighing 0.3g chitosan, be dissolved in 9.2g content and be that the volume fraction is 2% dilute acetic acid solution, be placed in constant temperature water bath pot and stir for 1.5 hours after dissolving, obtain chitosan solution; The temperature of the water bath is 25°C

[0038] S2. Preparation of mineralized collagen powder: Slowly add 0.055mol of phosphoric acid solution to the collagen solution; stir it at 25°C, and add calcium chloride solution dropwise at the same time; add dropwise during the stirring process after the addition Sodium hydroxide aqueous solution, so that the pH value of the solution is 7; put it aside for 4 hours, remove the supernatant, wash and filter, freeze-dry and grind to obtain mineralized collagen powder; the PO4 3- The ratio of the calcium-phosphorus moles of the solution and the calcium ion aqueo...

Embodiment 2

[0043] A preparation method of chitosan-graphene oxide composite gel, comprising the following steps:

[0044] S1, at room temperature, take by weighing 0.3g chitosan, be dissolved in 9.2g content and be that the volume fraction is 2% dilute acetic acid solution, be placed in constant temperature water bath pot and stir for 1.5 hours after dissolving, obtain chitosan solution; The temperature of the water bath is 25°C

[0045] S2. Preparation of mineralized collagen powder: Slowly add 0.055mol of phosphoric acid solution to the collagen solution; stir it at 25°C, and add calcium chloride solution dropwise at the same time; add dropwise during the stirring process after the addition Sodium hydroxide aqueous solution, so that the pH value of the solution is 7; put it aside for 4 hours, remove the supernatant, wash and filter, freeze-dry and grind to obtain mineralized collagen powder; the PO 4 3- The ratio of the calcium-phosphorus moles of the solution and the calcium ion aqu...

Embodiment 3

[0050] A preparation method of chitosan-graphene oxide composite gel, comprising the following steps:

[0051] S1, at room temperature, take by weighing 0.3g chitosan, be dissolved in 9.2g content and be that the volume fraction is 2% dilute acetic acid solution, be placed in constant temperature water bath pot and stir for 1.5 hours after dissolving, obtain chitosan solution; The temperature of the water bath is 25°C.

[0052] S2. Preparation of mineralized collagen powder: Slowly add 0.055mol of phosphoric acid solution to the collagen solution; stir it at 25°C, and add calcium chloride solution dropwise at the same time; add dropwise during the stirring process after the addition Sodium hydroxide aqueous solution, so that the pH value of the solution is 7; put it aside for 4 hours, remove the supernatant, wash and filter, freeze-dry and grind to obtain mineralized collagen powder; the PO 4 3- The ratio of the calcium-phosphorus moles of the solution and the calcium ion aq...

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Abstract

The invention discloses chitosan-graphene oxide composite gel and a preparation method thereof. The chitosan-mineralized collagen-graphene oxide composite hydrogel prepared by the invention has the characteristics of rapid gelatinization, self-healing and the like, and has biological 3D printability. After graphene oxide is added into the composite hydrogel, the mechanical property is enhanced, and the porous structure is beneficial to adhesion and growth of cells; and the biological printability is improved. The material is expected to be used as a tissue engineering scaffold material. The prepared composite hydrogel has the characteristics of shear thinning and good viscoelasticity, and a tissue engineering scaffold can be constructed through a biological 3D printing technology at 37 DEG C.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a chitosan-graphene oxide composite gel and a preparation method thereof. Background technique [0002] Looking at the whole world, in the field of bone repair, bone nonunion and bone defect caused by trauma, inflammation, tumor and other reasons have always been difficult problems in the field of orthopedic treatment. The most common traditional clinical method is to perform surgery on patients, but The sequelae produced by surgical operations are also a major problem that is difficult to solve. The versatility of human tissues and organs cannot be achieved by artificially manufactured substitutes, and transplanting other people's bone tissue often produces autoimmunity. In the case that these methods have defects such as applicability and complications, tissue engineering plays a vital role, and what material to use for bone grafting has always been the focus of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/08A61L27/20A61L27/50A61L27/52A61L27/56A61L27/24C08J3/075C08J3/24C08L5/08C08L89/00C08L71/02
CPCA61L27/08A61L27/20A61L27/24A61L27/50A61L27/52A61L27/56A61L2430/02A61L2430/06C08J3/075C08J3/246C08J2305/08C08J2471/02C08J2489/00C08K3/042C08L5/08
Inventor 胡堃胡苗苗杨桂娟王海波李路海危岩
Owner BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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