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Method for preparing ceramic-magnetofluid composite stent

A technology of composite stent and ceramic stent, applied in prosthesis, medical science, tissue regeneration, etc., can solve the problems of uneven coating on the surface of ceramic stent and insufficient bone formation of the stent

Active Publication Date: 2021-05-11
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to prepare a magnetic porous tissue engineering scaffold and solve the shortcomings of the existing coating technology on the surface of the ceramic scaffold that is unevenly coated, the present invention provides a method for preparing a ceramic-magnetic fluid composite scaffold
[0005] The principle of the present invention is as follows: in order to solve the problem of bone tissue engineering scaffold osteogenesis deficiency, the Fe 3 o 4 Attached to the surface of the stent in the form of magnetic fluid to create a new type of magnetic coating

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] (1) Preparation of ceramic support: mix ceramic powder with 4-8wt% PVA solution in a mass ratio (0.8-2): 1, continue to add 5-10wt% oleic acid of ceramic powder mass, and stir evenly to obtain ceramic Slurry, the porous ceramic support is printed by 3D gel, and then the printed support is dried, degreased, and sintered to obtain a ceramic matrix.

[0023] (2) Fe 3 o 4 Preparation of Nanomagnetic Particles: Preparation of Fe by Phacoemulsification and Compound Chemical Co-precipitation 3 o 4 Nano magnetic particles, the reaction equation is:

[0024] FeSO 4 +2FeCl 3 +8NH 4 OH→Fe 3 o 4 +6NH 4 Cl+(NH 4 ) 2 SO 4 +4H 2 o

[0025] Weigh a certain amount of FeCl 3 ·6H 2 O and FeSO 4 ·7H 2 O is respectively configured into a 0.3mol / L solution, according to the amount of substance n(Fe 3+ ):n(Fe 2+ )=3:2 Mix the two solutions and heat to about 50°C in a water bath. Use a ultrasonic emulsification disperser to ultrasonicate the mixture for 3 to 5 minutes, dis...

Embodiment 1

[0030] Embodiment 1: prepare the Fe of 2% volume fraction on calcium phosphate support 3 o 4 Ferrofluid

[0031] (1) Take 10g of 6%wt PVA solution, add 16g of calcium phosphate powder, continue to add 0.7ml of oleic acid, stir evenly to obtain calcium phosphate slurry, 3D gel prints out porous calcium phosphate ceramic support, and then prints The scaffold is dried, degreased and sintered to obtain a ceramic scaffold matrix.

[0032] (2) 8.34g FeSO 4 ·7H 2 O and 8.1 g FeCl 3 ·6H 2 O was added to 100ml deionized water to get Fe 2+ solution 40ml and Fe 3+ Mix 60ml of the solution, heat it in a water bath to 50°C, use an ultrasonic material emulsification disperser to ultrasonicate the mixed solution until it is evenly mixed, and measure 10ml of NH 3 ·H 2 O, during the ultrasonic process, slowly drop into the solution with a rubber dropper, after 7 minutes, the reaction is sufficient, use a magnet to attract, repeatedly wash the generated Fe with deionized water and alco...

Embodiment 2

[0035] Embodiment 2: prepare the Fe of 1% volume fraction on calcium silicate support 3 o 4 Ferrofluid

[0036] (1) Take 12g of 8%wt PVA, add 24g calcium silicate powder, continue to add 1ml of oleic acid, stir evenly to obtain calcium silicate slurry, 3D gel prints porous calcium silicate ceramic support, and then The printed scaffold was dried, degreased, and sintered to obtain a ceramic scaffold matrix.

[0037] (2) 8.34g FeSO 4 ·7H 2 O and 8.1 g FeCl 3 ·6H 2 O was added to 100ml deionized water to get Fe 2+ solution 40ml and Fe 3+ Mix 60ml of the solution, heat it in a water bath to 50°C, use an ultrasonic material emulsification disperser to ultrasonicate the mixed solution until it is evenly mixed, and measure 15ml of NH 3 ·H 2 O, during the ultrasonic process, slowly drop into the solution with a rubber dropper, after 10 minutes the reaction is sufficient, use a magnet to attract, repeatedly wash the generated Fe with deionized water and alcohol 3 o 4 Magneti...

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Abstract

The invention provides a method for preparing a ceramic-magnetofluid composite stent, and belongs to the field of composite material preparation. The preparation method comprises the following steps: firstly, printing a biological ceramic stent by adopting 3D gel, then preparing Fe3O4 magnetic nanoparticles by adopting an ultrasonic emulsification composite chemical coprecipitation method, then preparing Fe3O4 magnetic fluids with different volume fractions by adding different amounts of deionized water and a surfactant, dipping the ceramic stent which is subjected to 3D printing and sintering into the magnetic fluids, and then centrifuging and drying to obtain uniform Fe3O4 magnetic fluid coatings with different magnetisms on the surface of the stent. The method for preparing the magnetic nano coating is simple and stable to operate, the cost can be saved, and the production efficiency can be improved.

Description

technical field [0001] The invention relates to a method for preparing a ceramic-magnetic fluid composite support, which belongs to the field of composite material preparation. Background technique [0002] Magnetic fluid is composed of three parts: nano-scale solid magnetic particles, base fluid and surfactant. Usually, the magnetic nanoparticles are prepared by chemical co-precipitation method, and then the nanoparticles are coated and modified by adding a surfactant, so that they are evenly suspended in the base liquid to form a stable colloid. This is a new type of functional material, which has both the fluidity of liquid and the magnetism of solid magnetic materials. The fluid is non-magnetic in static state, and only exhibits magnetism when an external magnetic field is applied. The widely used solid magnetic particles are Fe 3 o 4 , γ-Fe 2 o 3 、MeFe 2 o 4 (Me=Co, Ni, Mg and other divalent cations), magnetic metal Co, Fe, Ni and their alloy particles, iron nit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/10A61L27/16A61L27/30A61L27/12B33Y70/10B33Y10/00B33Y80/00
CPCA61L27/56A61L27/10A61L27/16A61L27/306A61L27/12B33Y70/10B33Y10/00B33Y80/00A61L2430/02C08L29/04
Inventor 邵慧萍吴佳蕾林涛
Owner UNIV OF SCI & TECH BEIJING
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