Polymeric micelle drug-loaded composition for aerosol inhalation as well as preparation method and application of polymeric micelle drug-loaded composition
A technology of atomization inhalation and polymer glue, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problems of drug toxicity and side effects, and achieve the effect of high safety and improved stability
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Embodiment 1
[0060] The preparation of embodiment 1 voriconazole micelles
[0061] (1) Weigh 250 mg of mPEG-PDLLA and 40 mg of voriconazole at a room temperature of 10-30° C., place them in a mixed solution of 20 ml of glycerin (or propylene glycol) and 10 ml of ethanol, and stir slowly to dissolve. Under the condition of a magnetic stirring rate of 720rpm, slowly drop this solution into 20ml of sterile water for injection (WFI) at a rate of 1sec., and continue to stir for 10min. The obtained nanoparticle solution was rotary evaporated at 30° C. to remove the solvent to obtain a VCZ / mPEG-PDLLA-drug thin film. Dissolve the above VCZ / mPEG-PDLLA with 8 mL of sterile water for injection preheated to 30°C, and collect the dissolved matrix-drug film solution. Add 350 mg of mannitol or 50 mg of trehalose and 50 mg of sucrose to the solution, and continue stirring until the solution becomes clear.
[0062] (2) Take the filter membrane with hydrophilic polyvinylidene fluoride (PVDF) with a pore siz...
Embodiment 2
[0064] Embodiment 2 polymer micelles are selected
[0065] Tests have proved that the used auxiliary material mPEG-PDLLA has a very narrow molecular weight distribution coefficient and high purity, and its gel permeation chromatogram is shown in the attached figure 2 .
Embodiment 3
[0067] (1) Weigh 200 mg of mPEG-PDLLA and 10 mg of voriconazole at a room temperature of 10-30° C., place them in a mixed solution of 20 ml of glycerin (or propylene glycol) and 10 ml of ethanol, and stir slowly to dissolve. Under the condition of a magnetic stirring rate of 720rpm, slowly drop this solution into 20ml of sterile water for injection (WFI) at a rate of 1sec., and continue to stir for 10min. The obtained nanoparticle solution was rotary evaporated at 30° C. to remove the solvent to obtain a VCZ / mPEG-PDLLA-drug thin film. Dissolve the above VCZ / mPEG-PDLLA with 8 mL of sterile water for injection preheated to 30°C, and collect the dissolved matrix-drug film solution. Add 50 mg of sucrose to this solution, and continue stirring until the solution becomes clear.
[0068] (2) Take the filter membrane with hydrophilic polyvinylidene fluoride (PVDF) with a pore size of 0.2 μm, put it on the filter cartridge of the filter, assemble the filter, and put the assembled filt...
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