Multicompartment system of nanocapsule-in-nanocapsule type, for encapsulation of a lipophilic and hydrophilic compound, and the related production method
A technology of hydrophilic compounds and nanocapsules, applied in capsule delivery, nanocapsules, nanotechnology, etc., can solve problems such as incompatibility between carriers and drug systems, differences in insulin absorption, uncontrolled blood sugar, etc., and achieve improvement Bioavailability, simple and low preparation, and the effect of improving the scope of application
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Embodiment I
[0096] Process for preparing water-in-oil inverse emulsions.
[0097] For the production of inverse emulsions (W-O type), a water-ethanol solution of a lauryl derivative of hyaluronic acid is used. The volatile organic solvent is present to bring the polymer chains into an extended conformation (to create an inverse emulsion). The solvent was subsequently evaporated.
[0098] Solutions of hyaluronic acid dodecyl derivatives (hydrophobic side chain substitution degree starting from 4.5%) were prepared in physiological saline (concentration about 7.5 g / L). The neutral solution was then ethanolized to obtain a 2:3 volume ratio mixture.
[0099] At the same time, by mixing oleic acid with aqueous sodium chloride (c=0.15mol / dm 3 ) were mixed at a volume ratio of 100:1 to prepare a pre-emulsion. The system was vibrated in a vortex shaker for 10 minutes, and then subjected to sonication in an ultrasonic cleaner for 30 minutes at room temperature (pulse mode, 1 s sonication, 2 s i...
Embodiment II
[0103] A method for preparing a water-in-oil type inverse emulsion after reducing the content of the aqueous phase in the water-ethanol solution.
[0104] Pre-emulsions were prepared as described in Example 1. The water-ethanol solution of the dodecyl hyaluronic acid derivative is added gradually, but the volume ratio of the aqueous phase to the ethanol phase is 1:2.
[0105] To evaporate ethanol, the system was subjected to sonication at higher temperature (approximately 34°C).
[0106] Initially a white suspension may be seen in the oil. After the system was introduced into the cuvette for DLS measurement, the suspended matter turned into bubbles with a diameter of more than 1 mm ( figure 2 ).
[0107] After measuring the size in the DLS equipment, 2 large water droplets were observed in the cuvette.
[0108] Zeta potential cannot be measured.
[0109] Based on the results given in Examples I and II, it can be concluded that ethanol has an adverse effect on the emulsio...
Embodiment III
[0111] A method of preparing a water-in-oil inverse emulsion after removing alcohol from the system.
[0112] By adding hyaluronic acid dodecyl derivatives in normal saline (c NaCl =0.15mol / dm 3 ) solution (c=4.7g / L) was mixed with oleic acid at a volume ratio of 1:100 to prepare a water-in-oil type inverse emulsion. The system was subjected to vibration and sonication as described in Example I, and the sonication was continued for 1 hour.
[0113] A milky white emulsion was obtained and its stability was measured on the day of emulsification and after five days. DLS test showed that the initial system was highly stable (ζ=-33±21.7mV). Molecular sizes are characterized by a narrow distribution. After five days, the distribution characterizing the size of the molecules shifted towards smaller molecules; moreover, another small maximum could be observed. After five days, the turbidity of the sample was significantly reduced ( image 3 , Figure 4 , Figure 5 ). Visual o...
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