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Malic acid-chitosan nanopore hydrogel microspheres as well as preparation method and application thereof

A technology of chitosan nano and hydrogel microspheres, applied in chemical instruments and methods, other chemical processes, water/sewage treatment, etc.

Pending Publication Date: 2021-06-08
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, chitosan and malic acid are used as candidate materials to remove high-efficiency adsorbents for the adsorption and removal of paralytic shellfish toxins in water bodies.

Method used

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  • Malic acid-chitosan nanopore hydrogel microspheres as well as preparation method and application thereof
  • Malic acid-chitosan nanopore hydrogel microspheres as well as preparation method and application thereof
  • Malic acid-chitosan nanopore hydrogel microspheres as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation method of malic acid-chitosan nanoporous hydrogel microspheres

[0037] (1) Mix malic acid and chitosan (deacetylation degree 90%) according to the mass ratio of 1:3, add the mixture to pure water to prepare a dispersion with a mass fraction of 1.5%, stir vigorously at room temperature for 4 hours, and form a uniform malic acid-chitosan hydrosol.

[0038] (2) adding mass fraction to the hydrosol described in step (1) is 0.4% nano-silica and 1.0% glycerin, stirred at room temperature for 2 h, ultrasonically treated for 2 h, and the homogeneous sol obtained was added dropwise to The mass fraction is 10% NaOH solution, kept at 80°C for 2h to dissolve the silica particles and generate a porous structure. Finally, wash with distilled water to remove the remaining NaOH, freeze-dry and grind through a 100-mesh sieve, collect and store in a desiccator, such as figure 1 Shown is a schematic diagram of the synthesis of malic acid-chitosan nanoporous hydrog...

Embodiment 2

[0039] Example 2 Preparation method of malic acid-chitosan nanoporous hydrogel microspheres

[0040] (1) Mix malic acid and chitosan (90% degree of deacetylation) according to the mass ratio of 1:4, add the mixture to pure water to prepare a dispersion with a mass fraction of 0.5%, stir vigorously at room temperature for 4 hours, and form a uniform malic acid-chitosan hydrosol.

[0041] (2) Adding mass fraction of 0.2% nano silicon dioxide and 0.5% glycerin to the aqueous sol in step (1), stirring at room temperature for 2 h, ultrasonic treatment for 1 h, and adding the obtained homogeneous sol dropwise to The mass fraction is 8% NaOH solution, kept at 60°C for 2h to dissolve the silica particles and generate a porous structure. Finally, wash with distilled water to remove the remaining NaOH, freeze-dry, grind through a 100-mesh sieve, collect and store in a desiccator.

Embodiment 3

[0042] Example 3 Preparation method of malic acid-chitosan nanoporous hydrogel microspheres

[0043] (1) Mix malic acid and chitosan (90% degree of deacetylation) according to the mass ratio of 1:5, add the mixture to pure water to prepare a dispersion with a mass fraction of 1.5%, stir vigorously at room temperature for 4 hours, and form a uniform malic acid-chitosan hydrosol.

[0044](2) Adding mass fraction of 0.6% nano-silica and 1.0% glycerin to the hydrosol in step (1), stirring at room temperature for 3 h, ultrasonic treatment for 2 h, and adding the obtained homogeneous sol dropwise to The mass fraction is 10% NaOH solution, kept at 80°C for 1 h to dissolve the silica particles and generate a porous structure. Finally, wash with distilled water to remove the remaining NaOH, freeze-dry, grind through a 100-mesh sieve, collect and store in a desiccator.

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Abstract

The invention discloses malic acid-chitosan nanopore hydrogel microspheres as well as a preparation method and application thereof, and belongs to the technical field of guaranteeing the safety of aquatic food and preparing paralytic shellfish toxin bio-adsorbents. The invention discloses a preparation method of malic acid-chitosan nanopore hydrogel microspheres. The preparation method specifically comprises the following steps: preparing malic acid and chitosan into hydrogel; preparing a malic acid-chitosan nano-pore hydrogel microsphere, adding nano-silica and glycerin into the prepared hydrogel, adding sodium hydroxide, completely dissolving the nano-silica under an alkaline condition to form uniformly distributed nano-pores, performing washing, performing freeze-drying, and performing grinding and sieving to obtain the malic acid-chitosan nano-pore hydrogel microsphere. The malic acid-chitosan nanopore hydrogel microspheres prepared by the invention can be used as an efficient adsorbent for adsorbing and removing paralytic saxitoxin in a water body. The preparation method disclosed by the invention is simple, convenient to use and easy to store after being dried, and has great application significance on shellfish toxin pollution and improvement of product safety.

Description

technical field [0001] The invention relates to the technical field of ensuring the safety of aquatic food and preparing a paralytic shellfish toxin biosorbent, in particular to malic acid-chitosan nanoporous hydrogel microspheres and a preparation method and application thereof. Background technique [0002] Paralytic shellfish toxins are mainly derived from symbiotic bacteria of dinoflagellates, freshwater cyanobacteria or harmful algae. They are a type of marine biofilm neurotoxin, which specifically blocks Na on the nerve cell membrane. + The passage causes paralysis and even death. Filter-feeding shellfish and some fish eat poisonous algae, and the toxins accumulate in the body and can be transmitted to humans through the food chain, posing a serious threat to public safety, human health and marine economy. There are currently no effective antidotes or medications for paralytic shellfish poisoning. In order to reduce the harm of paralytic shellfish poisoning to humans...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30C02F1/28
CPCB01J20/103B01J20/22B01J20/24B01J20/28021B01J20/28047C02F1/286C02F1/288C02F2303/04
Inventor 解万翠杨锡洪宋琳车红霞董秀芳李红燕呼晓群郭浩
Owner QINGDAO UNIV OF SCI & TECH
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