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1, 3, 5, 7-tetramethylcyclotetrasiloxane-based ciprofloxacin fluorescent probe and application thereof in iron ion detection

A technology of tetramethylcyclotetrasiloxane ciprofloxacin and tetramethylcyclotetrasiloxane, which is applied in the field of fluorescence sensing, can solve problems such as interference and high detection limit, and achieve high application value and identification Effect of fast response, good selectivity and sensitivity

Active Publication Date: 2021-06-25
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

reported for Fe 3+ The detected fluorescent small molecule materials mainly include rhodamine molecules, tetraphenylethylene molecules, quinoline molecules and BODIPY molecules, etc. However, these fluorescent small molecule materials cannot exclude other metal ions such as Zn during the detection of iron ions. 2+ interference defects, and the Fe 3+ higher detection limit

Method used

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  • 1, 3, 5, 7-tetramethylcyclotetrasiloxane-based ciprofloxacin fluorescent probe and application thereof in iron ion detection
  • 1, 3, 5, 7-tetramethylcyclotetrasiloxane-based ciprofloxacin fluorescent probe and application thereof in iron ion detection
  • 1, 3, 5, 7-tetramethylcyclotetrasiloxane-based ciprofloxacin fluorescent probe and application thereof in iron ion detection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Dissolve 1.208mL (5.0mmol) of 1,3,5,7-tetramethylcyclotetrasiloxane in 2mL of anisole and place it in a 50mL two-neck flask, heat up to 80°C; add 120μL with a mass fraction of 1 % chloroplatinic acid-isopropanol solution; HBC 0.68g (1.25mmol) was dissolved in 20mL of anisole, and added dropwise to the two-neck flask; after reacting at 80°C for 8 hours; distillation under reduced pressure, the crude product Use chromatographic column separation and purification to obtain an orange-yellow solid, which is compound D 4 H-HBC.

Embodiment 2

[0033] Dissolve 0.604mL (2.5mmol) of 1,3,5,7-tetramethylcyclotetrasiloxane in 2mL of anisole and place it in a 50mL two-neck flask, heat up to 80°C; add 120μL with a mass fraction of 1 % chloroplatinic acid-isopropanol solution; HBC 0.68g (1.25mmol) was dissolved in 20mL of anisole, and added dropwise to the two-neck flask; after reacting at 80°C for 8 hours; distillation under reduced pressure, the crude product Use chromatographic column separation and purification to obtain an orange-yellow solid, which is compound D 4 H-HBC.

Embodiment 3

[0035] Test the fluorescence emission spectrum after the fluorescent probe prepared in Example 2 interacts with different metal ions, the specific method is as follows:

[0036] Press Fluorescent Molecular Probes D 4 H-HBC concentration is 10 -4 mol / L, the fluorescent molecular probe D 4 H-HBC was added to the ethanol solution, and then metal ions were added according to the concentration of metal ions at 5 μg / mL, and the fluorescence emission spectrum of the solution was measured, wherein the metal ions were respectively Cr 3+ , Ag + ,Co 2+ ,Cu 2+ ,K + , Ni 2+ ,Cd 2+ ,Pb 2+ , Ba 2+ ,Mg 2+ ,Al 3+ , Ca 2+ ,Zn 2+ , Na + , Li + , Ga 3+ ,Mn 2+ , these metals will not cause fluorescence quenching, when adding Fe 3+ ions, the fluorescence intensity is quenched to 1 / 7 of the original. Therefore, the fluorescent molecular probe D 4 H-HBC to Fe 3+ Have good selectivity and recognition ability.

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PUM

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Abstract

The invention discloses a 1,3, 5, 7-trimethylcyclotetrasiloxane-based ciprofloxacin fluorescent probe for detecting ferric ions. Ciprofloxacin modified by 1, 3, 5, 7-tetramethylcyclotetrasiloxane has bright green fluorescence, and when Fe<3+> ions appear, fluorescence quenching is generated, so that Fe<3+> detection is realized. The structural formula of the 1, 3, 5, 7-tetramethylcyclotetrasiloxane-based ciprofloxacin fluorescent probe is shown in the specification. The fluorescent probe provided by the invention has the characteristics of higher sensitivity, capability of resisting interference of other metal ions, good Fe<3+> selectivity, low detection limit and the like when being used for detecting iron ions.

Description

technical field [0001] The invention relates to the technical field of fluorescence sensing, in particular to a fluorescent probe and its application in iron ion detection. Background technique [0002] Iron is an indispensable trace element in the human body and an important component of hemoglobin, which is responsible for the transport of oxygen in living organisms. In addition, iron is involved in the composition of various immune systems and enzymes in the human body. The lack of iron in the body will cause iron deficiency anemia, insufficient cell supply, fatigue and burnout, and at the same time lead to a decline in human immunity. Iron deficiency in childhood will affect children's psychological activities and intellectual development, and the process is irreversible. Excess iron in the human body will lead to iron overload in the liver, causing diseases such as liver fibrosis and hepatoma, and even lead to an imbalance in the body's oxidation-antioxidation system,...

Claims

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Application Information

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IPC IPC(8): C07F7/21C09K11/06G01N21/64
CPCC07F7/21C09K11/06G01N21/6428C09K2211/1096C09K2211/1029C09K2211/1044G01N2021/6432
Inventor 邓卫星周凯丽彭锦雯徐旭刘远立余传柏
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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