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Novel degradable intravascular stent and manufacturing method thereof

A vascular stent and a manufacturing method technology, applied in the field of new degradable vascular stent and its manufacturing, can solve the problems of fast corrosion degradation, poor plastic deformation, low elongation rate, etc., and achieve the promotion of re-endothelialization, high strength, reduced The effect of small coverage

Inactive Publication Date: 2021-07-16
金皓天
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing materials for degradable stents on the market, there are problems such as low elongation, high brittleness, poor plastic deformation, and fast corrosion degradation. Therefore, an optimized degradable vascular stent made of zinc alloy material was developed. is essential

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A new type of degradable vascular stent, including: zinc alloy and natural degradable polymer materials, the zinc alloy contains 4mg of zinc element, the diameter of its crystal grains is 10nm, and the natural degradable polymer is prepared on the surface of the zinc alloy The coating of the material is to set a layer of drug coating on the coating of the natural degradable polymer material.

[0018] A new type of degradable vascular stent and its manufacturing method. The material of the vascular stent is cut and melted, vaporized, ablated or reached the ignition point by a three-dimensional laser, and the material of the vascular stent is cut and positioned by a positioning control system, and then coaxially The high-speed airflow blows off the molten material to cut the material, evenly coats the surface of the cut and formed material with a natural degradable polymer material, and finally coats the coating of the natural degradable polymer material with a drug coatin...

Embodiment 2

[0020] The zinc alloy in the new degradable vascular stent contains 7mg of zinc element, and the diameter of its crystal grains is 15nm. A coating of natural degradable polymer material is prepared on the surface of the zinc alloy. A layer of drug coating is arranged on the coating, the drug coating is poly-L-lactic acid or chitosan, the coating thickness of the natural degradable polymer material is 150nm, the thickness of the drug coating is not greater than 150nm, and the material of the vascular stent passes through The long-pulse width laser cuts the material to make a degradable vascular stent.

Embodiment 3

[0022] The zinc alloy in the new degradable vascular stent contains 10mg of zinc element, and the diameter of its grain is 17nm. A coating of natural degradable polymer material is prepared on the surface of the zinc alloy. A layer of drug coating is arranged on the coating, the drug coating is poly-L-lactic acid or chitosan, the coating thickness of the natural degradable polymer material is 260nm, the thickness of the drug coating is not more than 150nm, and the material of the vascular stent passes through The segment pulse width laser cuts the material to make a degradable vascular stent.

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Abstract

The invention relates to a degradable stent used in blood vessels, in particular to a novel degradable intravascular stent and a manufacturing method thereof. The novel degradable intravascular stent comprises a zinc alloy and a natural degradable high polymer material, the zinc alloy contains 4-10 mg of zinc element, the grain diameter is 10-17 nm, a coating made of the natural degradable high polymer material is prepared on the surface of the zinc alloy, and a medicine coating is arranged on the coating made of the natural degradable high polymer material; the degradable intravascular stent has higher strength and better ductility by improving the zinc alloy material and optimizing the processing technology, the supporting force of the novel intravascular stent is increased, and the coverage rate of the stent is reduced; By smearing a proper coating, the effects of promoting re-endothelialization, improving the endothelial function, reducing inflammatory response and inhibiting hyperplasia of neointima can be achieved.

Description

technical field [0001] The invention relates to a degradable stent used in blood vessels, and specifically proposes a novel degradable vascular stent and a manufacturing method thereof. Background technique [0002] Vascular stent angioplasty is an interventional operation in which stents are implanted in the body to support blood vessels and compress intravascular plaques to prevent vascular rebound and intimal plaques from protruding into the blood vessels. After the stents are delivered to the lesion through the delivery system Plastic expansion to keep the blood flow unobstructed. At present, vascular stents have been widely used in the treatment of coronary artery, intracranial artery, carotid artery, renal artery and femoral artery and other vascular diseases, and have achieved remarkable results. [0003] At present, the main forms of vascular stents are: bare metal stents, drug-eluting stents, and degradable stents. Bare metal stents are likely to induce adverse reac...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/02A61L31/14A61L31/16
CPCA61L31/022A61L31/10A61L31/148A61L31/16A61L2420/08C08L67/04C08L5/08
Inventor 金皓天
Owner 金皓天
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