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Cerium-based nano composite material and preparation method and application thereof

A nanocomposite material, cerium-based technology, applied in the direction of analyzing materials, material excitation analysis, material analysis through optical means, etc., can solve problems such as limiting biological applications, achieve reasonable process design, promote wound healing, and good photostability Effect

Inactive Publication Date: 2021-07-20
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cerium oxide nanoparticles can only be dispersed rather than dissolved in water, which limits its biological application. Therefore, the development of water-soluble cerium-based composite nanomaterials is more conducive to wound repair and has greater clinical application prospects.

Method used

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  • Cerium-based nano composite material and preparation method and application thereof
  • Cerium-based nano composite material and preparation method and application thereof
  • Cerium-based nano composite material and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] The preparation method of cerium-containing carbon quantum dot nanocomposite material 1 comprises the following steps:

[0042]Step 1: Weigh 0.800g of cerium nitrate hexahydrate, dissolve 1.062g of citric acid in 20mL of deionized water, stir for 1 hour to dissolve, then measure 1.11mL of ethylenediamine (the molar ratio of ethylenediamine to citric acid is 3:1 ), added in the above mixed solution, fully mixed;

[0043] Step 2: Add the mixed solution into a polytetrafluoroethylene reactor, react at 200°C for 4 hours, and naturally cool to room temperature to obtain a product solution;

[0044] Step 3: Centrifuge the product solution at a speed of 2000 rpm to remove insoluble substances in the product solution, dialyze the supernatant with a dialysis bag with a molecular weight of 1000Da for 5 days to remove unreacted small molecular substances, and then The dialyzed solution was freeze-dried to obtain a brown-red powdery cerium-containing carbon quantum dot nanocomposi...

Embodiment 2

[0046] The preparation method of cerium-containing carbon quantum dot nanocomposite material 2 comprises the following steps:

[0047] Step 1: Weigh 0.800g of cerium nitrate hexahydrate, dissolve 1.062g of citric acid in 20mL of deionized water, stir for 1 hour to dissolve, then measure 0.37mL of ethylenediamine (the molar ratio of ethylenediamine to citric acid is 1:1 ), added in the above mixed solution, fully mixed;

[0048] Step 2: Add the mixed solution into a polytetrafluoroethylene reactor, react at 200°C for 4 hours, and naturally cool to room temperature to obtain a product solution;

[0049] Step 3: Centrifuge the product solution at a speed of 2000 rpm to remove insoluble substances in the product solution, dialyze the supernatant with a dialysis bag with a molecular weight of 1000Da for 5 days to remove unreacted small molecular substances, and then The dialyzed solution was freeze-dried to obtain a brownish-red powdery cerium-containing carbon quantum dot nanocom...

Embodiment 3

[0051] The preparation method of cerium-containing carbon quantum dot nanocomposite material 3 comprises the following steps:

[0052] Step 1: Weigh 0.800g cerium nitrate hexahydrate, dissolve 1.062g citric acid in 20mL deionized water, stir for 1 hour to dissolve, then measure 1.48mL ethylenediamine (the molar ratio of ethylenediamine to citric acid is 4:1 ), added in the above mixed solution, fully mixed;

[0053] Step 2: Add the mixed solution into a polytetrafluoroethylene reactor, react at 200°C for 4 hours, and naturally cool to room temperature to obtain a product solution;

[0054] Step 3: Centrifuge the product solution at a speed of 2000 rpm to remove insoluble substances in the product solution, dialyze the supernatant with a dialysis bag with a molecular weight of 1000Da for 5 days to remove unreacted small molecular substances, and then The dialyzed solution was freeze-dried to obtain a brown-red powdery cerium-containing carbon quantum dot nanocomposite material...

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Abstract

The invention discloses a cerium-based nano composite material and a preparation method thereof. The preparation method comprises a pretreatment step and a step of compounding cerium ions with carbon quantum dots and / or natural macromolecules. The cerium-based nano composite material disclosed by the invention can comprise a cerium-containing carbon quantum dot nano composite material and / or cerium ion cross-linked sodium alginate pellets. The cerium-based nano composite material can be applied to wound healing, and has multiple characteristics of promoting wound healing, resisting bacteria, realizing fluorescence and the like.

Description

technical field [0001] The invention belongs to the technical field of composite biomaterials, and in particular relates to a cerium-based nanocomposite material and its preparation method and biological application. Background technique [0002] Wound healing can generally be divided into four intersecting processes, namely hemostasis, inflammation, proliferation, and extracellular matrix remodeling. Hemostasis is the first stage after skin injury, after which an inflammatory response occurs at the wound site, the purpose of which is to prevent the wound from being infected by bacteria and remove damaged cells and other debris through endocytosis. This process can effectively inhibit bacterial proliferation, thereby accelerating Wound healing process. However, an excessive inflammatory response often occurs near the wound, producing excess reactive oxygen species and causing oxidative stress. Oxidative stress in the body induces oxidative damage to cells, hinders cell pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/42A61L15/44G01N21/64G01N21/84
CPCA61L15/18A61L15/28A61L15/42A61L15/44G01N21/6428G01N21/84A61L2300/412A61L2300/102A61L2300/41A61L2300/108A61L2300/404A61L2400/12C08L5/04C08L5/08
Inventor 杜亚平翟欣昀张萌真
Owner NANKAI UNIV
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