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Traditional Chinese medicine composition for relieving and repairing as well as preparation method and application of traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of soothing and repairing traditional Chinese medicine composition and its preparation, can solve the problems of few action targets and inability to relieve irritation in all directions, and achieve excellent effect and improve the effect of fragile skin quality

Inactive Publication Date: 2021-08-24
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the traditional Chinese medicine plant extracts used in soothing products on the market are extracted from a single category, with few targets, and cannot relieve irritation in an all-round way

Method used

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  • Traditional Chinese medicine composition for relieving and repairing as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for relieving and repairing as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for relieving and repairing as well as preparation method and application of traditional Chinese medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment

[0037] Preparation:

[0038] In the present embodiment, the Chinese medicine composition of the present application is prepared by the following method:

[0039] The hemp extract, Zanthoxylum bungeanum extract, Houttuynia cordata extract, and Cornus officinalis fruit extract are mixed according to the corresponding proportion, and then homogenized in a homogenizer to obtain the desired traditional Chinese medicine composition.

[0040] Wherein, the cannabis fermentation filtrate is prepared through the following steps:

[0041] Dry the marijuana leaves, crush and sieve, add distilled water, mix well to obtain a mixed solution, and then add 25% of the total volume of the mixed solution yeast fermentation broth, at 25-35 ° C, pH value 5-7, fermenter speed Under the condition of 200r / min, ferment for 48h, sterilize and filter to obtain the cannabis fermentation filtrate;

[0042] The distilled water is 15 times the quality of the cannabis leaf, and the yeast content of the yeas...

experiment example 1

[0057] Experimental Example 1: Hyaluronidase Activity Inhibition Experiment

[0058] Test sample: embodiment 1-20 and comparative example 1-4

[0059] Test method: take 0.1mL0.25mmol / LCaCl 2 Solution and 0.5mL hyaluronidase solution were incubated at 37°C for 20min; respectively, 0.5mL of the composition of the embodiment was added, and the incubation was continued at 37°C for 20min; 0.5mL sodium hyaluronate solution was added and incubated at 37°C for 30min, and placed at room temperature for 5min; 0.1mL of 0.4mol / L NaOH solution and 0.5mL of acetylacetone solution, heated in a boiling water bath for 15min, then immediately cooled with ice water for 5min; added 1ml of Ehrlich reagent and diluted with 3ml of absolute ethanol, left for 20min to develop color, Absorbance was measured colorimetrically at 585 nm with a spectrophotometer.

[0060] Antiallergic activity calculation formula:

[0061] Hyaluronidase inhibition rate = [(A-B)-(C-D)] / (A-B)*100%

[0062] A--ABS value o...

experiment example 2

[0070] Experimental Example 2: Anti-inflammatory Efficacy Experiment

[0071] Test samples: mouse macrophage cell line RAW264.7, mouse prostate E2 (PEG2) ELISA kit, mouse tumor necrosis factor-α (TNF-α) ELISA kit, lipopolysaccharide (LPS)

[0072] Test method: (1) Use the MTT method to detect the effect of the traditional Chinese medicine composition on the growth of RAW264.7 cells, adjust the density of RAW264.7 cells to 5*104 / mL, inoculate in 96-well cell culture plates, 1000 μL per well, place in Cultivate in a 37°C, 5% CO2 cell incubator for 24 hours. After the culture was finished, the culture medium in the cell plate was sucked out, and the concentration of 500 μg / mL and 200 μg / mL were added to the treatment group respectively. The traditional Chinese medicine composition medium of different combinations, and the blank control group was added with an equal volume of serum-free medium, and the cultivation was continued for 24 hours. 3 replicate wells in each group. Afte...

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Abstract

The invention discloses a traditional Chinese medicine composition for relieving and repairing as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from a cannabis sativa extract, a herba houttuyniae extract, a zanthoxylum bungeanum fruit extract and a dogwood fruit extract. Compared with the prior art, the traditional Chinese medicine composition for relieving and repairing, provided by the invention, has the advantages that all the components have a synergistic effect, and the traditional Chinese medicine composition is mild and effective and can relieve skin, resist inflammation, relieve itching and reduce adverse reactions caused by irritation; and the prepared product is stable in performance, and the preparation method is simple, easy to operate and easy for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a traditional Chinese medicine composition for soothing and repairing and its preparation method and application. Background technique [0002] The International Forum for the Study of Itching (IFSI) 2016 defines sensitive skin as an unpleasant sensation (burning, burning, pain, itching, stinging), usually caused by some non-irritating ingredients, sometimes accompanied by Redness of the skin. More and more people are more prone to skin sensitivity problems, such as skin redness, heat, and red blood on the face. In addition to being affected by environmental factors and seasonal changes, part of the reason is the use of inferior hormone-containing skin care products. The skin cells are damaged, the stratum corneum becomes thinner, unable to resist external stimuli, resulting in discomfort such as redness, itching, and tingling. [0003] Modern cosmetics often use ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61P29/00
CPCA61K8/9789A61Q19/00A61Q19/005A61P29/00A61K2800/85A61K2800/5922A61K2800/782
Inventor 李品一周秋娜金荣熙田星星权泰希金延埈
Owner COSMAX CHINA INC
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