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Micro-current elastic dressing for chronic wound healing, and preparation method thereof

A chronic wound, micro-current technology, applied in pharmaceutical formulations, electrospinning, textile material processing, etc., can solve the problems of deterioration, high permeability, unsanitary cotton flocks, etc., to promote cell proliferation and differentiation, improve Piezoelectric effect, the effect of promoting wound healing

Inactive Publication Date: 2021-08-27
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if its permeability is too high, it is easy to cause dehydration of the wound surface, it is difficult to effectively promote wound healing, it may cause secondary mechanical damage during replacement, and unsanitary problems such as falling cotton wadding cannot be ignored. Wound cross-infection further worsens the wound condition

Method used

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  • Micro-current elastic dressing for chronic wound healing, and preparation method thereof
  • Micro-current elastic dressing for chronic wound healing, and preparation method thereof
  • Micro-current elastic dressing for chronic wound healing, and preparation method thereof

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preparation example Construction

[0027] The invention provides a micro-current elastic dressing for chronic wound healing and a preparation method thereof. Using polyvinylidene fluoride, water-based polyurethane and zinc acetate as raw materials, a composite nanofiber membrane with a core-shell structure is prepared by electrospinning technology. After hydrothermal reaction, the surface of the composite nanofibrous membrane is loaded with dense and highly oriented zinc oxide nanorods, and a microcurrent elastic dressing that promotes chronic wound healing, has high voltage effect and antibacterial properties is obtained.

[0028] The preparation method of the described micro-current elastic dressing for chronic wound treatment comprises the steps:

[0029] S1, preparation of spinning solution

[0030] S1.1. Spinning solution for nuclear layer: use N-N dimethylformamide (DMF) and acetone as solvent (mass ratio is 3:2), add a certain amount of water-based polyurethane solution, and mix well;

[0031] S1.2 Shel...

Embodiment 1

[0047] 1.1. Preparation of spinning solution

[0048] 1.1.1. Spinning liquid for core layer: use N-N dimethylformamide (DMF) and acetone as solvent (mass ratio 3:2), add 10% aqueous polyurethane solution, mix well and then spin ;

[0049] 1.1.2. Shell spinning solution: use DMF and acetone as solvents, add 0.112g of 1% zinc acetate powder, and disperse by ultrasonic for 60min. After the ultrasound was completed, 1.126 g of 10% 700,000 polyvinylidene fluoride powder was added to the mixed solution, and it was placed in a constant temperature heating magnetic stirrer at 85°C and stirred until it was completely dissolved. After uniformity, a mixed solution of zinc acetate with different mass fractions was obtained.

[0050] 1.2. Electrospinning

[0051] Using a high-voltage electrospinning machine, set the spinning voltage to 16-18kV, the receiving distance to 12-18cm, the spinning rate to 0.015-0.019mL / min, and choose 22G (inner diameter 0.41mm, outer diameter 0.72mm) / 17G (inn...

Embodiment 2

[0055] 2.1. Preparation of spinning solution

[0056] 2.2.1. Spinning solution for the core layer: use N-N dimethylformamide (DMF) and acetone as solvents (mass ratio 3:2), add 20% aqueous polyurethane solution, and mix well;

[0057] 2.2.2. Sheath spinning solution: DMF and acetone are also used as solvents, 0.227g of 2% zinc acetate powder is added, and ultrasonically dispersed for 60min. After the ultrasonication was completed, 1.136g of 10% 700,000 polyvinylidene fluoride powder was added to the mixed solution, placed in a constant temperature heating magnetic stirrer at 85°C and stirred until completely dissolved, and mixed solutions of zinc acetate with different mass fractions were obtained after uniformity.

[0058] 2.2. Electrospinning

[0059] Using a high-voltage electrospinning machine, set the spinning voltage to 16-18kV, the receiving distance to 12-18cm, the spinning rate to 0.015-0.019mL / min, and choose 22G (inner diameter 0.41mm, outer diameter 0.72mm) / 17G (i...

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Abstract

The invention provides a micro-current elastic dressing for chronic wound healing, and a preparation method thereof. A composite nanofiber membrane of a core-shell structure is prepared from polyvinylidene fluoride, waterborne polyurethane and zinc acetate through an electrostatic spinning technology, and a hydrothermal reaction is carried out to make the surface of the composite nanofiber membrane loaded with compact and highly-oriented zinc oxide nanorods, so that the micro-current elastic dressing which can promote chronic wound healing and has high piezoelectric effect and antibacterial property is obtained. The micro-current elastic dressing for chronic wound healing has the advantages of stable micro-current output, good antibacterial performance, high elasticity and the like, and is particularly suitable for chronic wound treatment.

Description

technical field [0001] The invention belongs to the technical field of biomedical textiles, and in particular relates to a microcurrent elastic dressing for chronic wound healing and a preparation method thereof. Background technique [0002] With the aging of modern society and the development of industrialization, all kinds of skin diseases not only seriously threaten the health of human life, but also bring a heavy burden to the social economy, which is a hot issue of common concern all over the world. Chronic non-healing wounds refer to wounds that take a long time to heal, have dysfunctional body functions, and cannot undergo spontaneous tissue repair. Among them, pressure ulcers, venous ulcers, and diabetic feet are the three most common types of chronic wounds. It has been reported that about 7.8% of diabetic patients in my country have diabetic foot complications, while in developed countries, about 2% of the population is troubled by chronic wound diseases. In the U...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/42A61L15/18A61L15/24A61L15/26A61L15/20D04H1/541D04H1/728D06B3/10D01D5/00D01D5/34
CPCA61L15/46A61L15/42A61L15/18A61L15/24A61L15/26A61L15/20A61L15/425D04H1/5412D04H1/728D06B3/10D01D5/003D01D5/0092D01D5/0061D01D5/0069D01D5/34A61L2300/102A61L2300/404A61L2400/12
Inventor 李大伟付译鋆成悦李朝威陈迟左涵张海峰张伟张瑜
Owner NANTONG UNIVERSITY