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Degradable polyurethane biological material as well as preparation method and application thereof

A biomaterial and polyurethane technology, applied in the field of degradable polyurethane biomaterials and its preparation, can solve the problems of secondary cracking of wounds, affecting patient recovery, and reduced mechanical strength, and achieve simple process, excellent mechanical properties and degradation performance, and good Effect of mechanical properties and degradation properties

Pending Publication Date: 2021-08-31
厦门瑞聚医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the rapid degradation of chitosan, the mechanical strength decreases rapidly during actual use, and it is difficult to maintain sufficient strength before the patient's wound recovers, which may easily cause secondary cracking of the wound and affect the patient's recovery.

Method used

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  • Degradable polyurethane biological material as well as preparation method and application thereof

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Effect test

Embodiment 1

[0033] A method for preparing a degradable polyurethane biomaterial, comprising coaxial electrospinning the first solution and the second solution to obtain the polyurethane biomaterial; wherein, the preparation method of the first solution is as follows:

[0034] (A) First add lysine monomer and p-nitrophenyl adipate monomer into N,N-dimethylacetamide, stir and mix well, stir and react at 65°C for 40 minutes, then add nano calamine powder , continue to insulate and stir the reaction, and post-process to obtain nanoparticles;

[0035] (B) then add casein and acrylic acid to water, stir and mix well, under the condition of nitrogen protection, add potassium persulfate, stir and react, add the nanoparticles obtained in step (A), electron beam irradiation, post-treatment, and make the modified Nanoparticles;

[0036] (C) Finally, adding polyether glycol, modified nanoparticles, and dibutyltin dilauric acid into N,N-dimethylacetamide, and ultrasonically oscillating evenly to obta...

Embodiment 2

[0051] A method for preparing a degradable polyurethane biomaterial, comprising coaxial electrospinning the first solution and the second solution to obtain the polyurethane biomaterial; wherein, the preparation method of the first solution is as follows:

[0052] (A) First add lysine monomer and p-nitrophenyl adipate monomer into N,N-dimethylacetamide, stir and mix well, stir and react at 75°C for 30 minutes, then add nano calamine powder , continue to insulate and stir the reaction, and post-process to obtain nanoparticles;

[0053] (B) then add casein and acrylic acid to water, stir and mix well, under the condition of nitrogen protection, add potassium persulfate, stir and react, add the nanoparticles obtained in step (A), electron beam irradiation, post-treatment, and make the modified Nanoparticles;

[0054] (C) Finally, adding polyether glycol, modified nanoparticles, and dibutyltin dilauric acid into N,N-dimethylacetamide, and ultrasonically oscillating evenly to obta...

Embodiment 3

[0069] A method for preparing a degradable polyurethane biomaterial, comprising coaxial electrospinning the first solution and the second solution to obtain the polyurethane biomaterial; wherein, the preparation method of the first solution is as follows:

[0070] (A) First add lysine monomer and p-nitrophenyl adipate monomer into N,N-dimethylacetamide, stir and mix well, stir and react at 70°C for 35 minutes, then add nano calamine powder , continue to insulate and stir the reaction, and post-process to obtain nanoparticles;

[0071] (B) then add casein and acrylic acid to water, stir and mix well, under the condition of nitrogen protection, add potassium persulfate, stir and react, add the nanoparticles obtained in step (A), electron beam irradiation, post-treatment, and make the modified Nanoparticles;

[0072] (C) Finally, adding polyether glycol, modified nanoparticles, and dibutyltin dilauric acid into N,N-dimethylacetamide, and ultrasonically oscillating evenly to obta...

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Abstract

The invention provides a degradable polyurethane biological material as well as a preparation method and application thereof. According to the method, the degradable polyurethane biological material is obtained by performing electrostatic spinning on a first solution and a second solution; a preparation method of the first solution comprises the following steps of adding a lysine monomer and a p-nitrophenyl adipate monomer into N, N-dimethylacetamide, heating and stirring to react, adding nano calamine powder, and continuously reacting to obtain nano particles; adding casein and acrylic acid into water, uniformly stirring and mixing, under the protection of nitrogen, adding potassium persulfate, stirring and reacting, adding the nano particles, and irradiating by electron beams to prepare modified nano particles; and finally, adding polyether glycol, the modified nanoparticles and dibutyltin dilaurate into N, N-dimethylacetamide, and carrying out ultrasonic oscillation uniformly to obtain the degradable polyurethane biological material, wherein the second solution is prepared by adding diisocyanate into the N, N-dimethylacetamide and uniformly stirring and mixing. The biological material prepared by the invention has excellent mechanical property and degradation property and wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to a biodegradable polyurethane biomaterial and its preparation method and application. Background technique [0002] Suture thread is one of the necessary materials for suturing incisions after clinical operations, which is of great significance for accelerating incision healing and reducing postoperative complications. Sutures are generally divided into absorbable sutures and non-absorbable sutures. Among them, absorbable sutures, also known as biodegradable sutures, usually refer to sutures that lose most of their tensile strength within 60 days of being implanted subcutaneously, and in Within 1 to 6 months, it gradually becomes a substance that can be absorbed by the body through degradation. Absorbable sutures avoid the inflammatory response and other adverse effects caused by the long-term presence of foreign bodies in the body, and also avoid secondary oper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/00D01F6/94D01F1/10
CPCA61L17/10A61L17/00D01F6/94D01F1/10A61L2400/12C08L75/08
Inventor 蓝志元谭斌
Owner 厦门瑞聚医学科技有限公司
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