Cascade catalytic platform modified intraocular lens and preparation method of intraocular lens
A technology of intraocular lens and platform, applied in the direction of prosthesis, medical formula, coating, etc., can solve the problems of toxic and side effects of tissues around the eye, and achieve the effects of high intraocular biocompatibility, low cost, and simple manufacturing process
Active Publication Date: 2021-09-03
WENZHOU MEDICAL UNIV
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Abstract
The invention specifically relates to the technical field of ophthalmic medical implant materials and instrument surface modification, and in particular relates to a cascade catalytic platform modified intraocular lens and a preparation method of the intraocular lens. The surface of the intraocular lens is modified with a layer of cascade catalytic platform which takes intraocular glucose as a substrate to promote generation of endogenous active oxygen. The generated active oxygen can promote apoptosis and necrosis of residual lens epithelial cells, so that a good posterior cataract prevention and treatment effect is achieved under the condition that no toxic or side effect medicine is introduced, and the intraocular lens with high intraocular biocompatibility and the good posterior cataract prevention and treatment effect is obtained. According to the invention, a dual-enzyme-loaded cascade catalysis platform is constructed through a simple amidation reaction, and the dual-enzyme-loaded cascade catalysis platform is further modified to the surface of the intraocular lens through the action of an amido bond, so that the preparation process is simple, and the dual-enzyme-loaded cascade catalysis platform can be used for surface modification of various medical implantable devices, and is convenient to manufacture, low in cost, high in safety and convenient for industrial production.
Application Domain
Pharmaceutical delivery mechanismTissue regeneration +2
Technology Topic
Intraocular lensImplant material +15
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