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Cascade catalytic platform modified intraocular lens and preparation method of intraocular lens

A technology of intraocular lens and platform, applied in the direction of prosthesis, medical formula, coating, etc., can solve the problems of toxic and side effects of tissues around the eye, and achieve the effects of high intraocular biocompatibility, low cost, and simple manufacturing process

Active Publication Date: 2021-09-03
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned method of loading drugs on the surface of the intraocular lens has a certain preventive effect on post-cataract, but the drugs released after lens implantation will inevitably have certain toxic and side effects on the surrounding tissues in the eye

Method used

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  • Cascade catalytic platform modified intraocular lens and preparation method of intraocular lens
  • Cascade catalytic platform modified intraocular lens and preparation method of intraocular lens
  • Cascade catalytic platform modified intraocular lens and preparation method of intraocular lens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] First, take a clean intraocular lens, immerse it in a 50 mg / mL polyethyleneimine aqueous solution, and stir it at room temperature for 12 hours to modify the surface of the intraocular lens with amino groups, wash it with water, and dry it with nitrogen gas for later use.

[0031] Next, take 50 mg / mL mesoporous silica nanoparticles, 10 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 10 mg / mL N-hydroxy Succinimide was uniformly mixed with 10 mg / mL glucose oxidase and 10 mg / mL horseradish peroxidase in the aqueous system, adjusted to pH 7.4, stirred at 4°C for 24 hours, washed with phosphate aqueous buffer solution for 3 The second time, the cascade catalytic platform was obtained by centrifugal collection.

[0032] Finally, take 50 mg / mL Cascade catalytic platform, 10 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 10 mg / mL N-hydroxysuccinyl Mix the amines uniformly in the aqueous solution system, put them into the surface-aminated ...

Embodiment 2

[0038] First, take a clean intraocular lens, immerse it in a 0.3 mg / mL polyethyleneimine aqueous solution, and stir it at room temperature for 24 hours to modify the surface of the intraocular lens with amino groups, wash it with water, and dry it with nitrogen gas for later use.

[0039] Next, take 0.5 mg / mL protein scaffold, 0.1 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.1 mg / mL N-hydroxysuccinimide and 0.01 mg / mL gold nanoparticles and 0.01 mg / mL hemoglobin were uniformly mixed in the aqueous solution system, adjusted to pH 7.2, stirred at 4°C for 12 hours, washed 3 times with phosphate aqueous buffer solution, and collected by centrifugation to obtain the cascade catalytic platform.

[0040] Finally, take 0.5 mg / mL Cascade catalytic platform, 0.1 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.1 mg / mL N-hydroxysuccinimide Mix the amines uniformly in the aqueous solution system, put them into the surface-aminated intraocular l...

Embodiment 3

[0042] First, take a clean intraocular lens, immerse it in a 20 mg / mL polyethyleneimine aqueous solution, and stir it at room temperature for 36 hours to modify the surface of the intraocular lens with amino groups, wash it with water, and dry it with nitrogen gas for later use.

[0043] Next, take 20 mg / mL polymersomes, 5 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 5 mg / mL N-hydroxysuccinyl Amine, 1 mg / mL graphitic carbon nitride nanomaterials and 1 mg / mL ceria nanoparticles were uniformly mixed in the aqueous solution system, adjusted to pH 7.0, stirred at 4°C for 6 hours, washed with phosphate aqueous buffer solution for 3 The second time, the cascade catalytic platform was obtained by centrifugal collection.

[0044] Finally, take 20 mg / mL Cascade Catalytic Platform, 5 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 5 mg / mL N-hydroxysuccinyl Mix the amines uniformly in the aqueous solution system, put them into the surface-aminate...

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Abstract

The invention specifically relates to the technical field of ophthalmic medical implant materials and instrument surface modification, and in particular relates to a cascade catalytic platform modified intraocular lens and a preparation method of the intraocular lens. The surface of the intraocular lens is modified with a layer of cascade catalytic platform which takes intraocular glucose as a substrate to promote generation of endogenous active oxygen. The generated active oxygen can promote apoptosis and necrosis of residual lens epithelial cells, so that a good posterior cataract prevention and treatment effect is achieved under the condition that no toxic or side effect medicine is introduced, and the intraocular lens with high intraocular biocompatibility and the good posterior cataract prevention and treatment effect is obtained. According to the invention, a dual-enzyme-loaded cascade catalysis platform is constructed through a simple amidation reaction, and the dual-enzyme-loaded cascade catalysis platform is further modified to the surface of the intraocular lens through the action of an amido bond, so that the preparation process is simple, and the dual-enzyme-loaded cascade catalysis platform can be used for surface modification of various medical implantable devices, and is convenient to manufacture, low in cost, high in safety and convenient for industrial production.

Description

technical field [0001] The invention specifically relates to the technical field of ophthalmic medical implant materials and device surface modification, in particular to an intraocular lens modified by a cascade catalytic platform and a preparation method thereof. Background technique [0002] Cataract is the most common blinding eye disease. Surgery to remove the opaque lens and implant an intraocular lens is currently an effective means of clinical treatment of cataract. After the implantation of various existing lenses, the proliferation, migration and differentiation of the residual lens epithelial cells will cause the lens capsule to become cloudy again, that is, the formation of post-cataract, which will lead to decreased vision, blurred vision or glare, and even cause the first Blind for the second time. Post-cataract is the most common complication after cataract surgery, which seriously affects the recovery of postoperative visual acuity. The incidence of post-c...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/30A61L27/28A61L27/50
CPCA61L27/34A61L27/306A61L27/28A61L27/50A61L2430/16A61L2400/12C08L89/00
Inventor 林全愧黄慧颖
Owner WENZHOU MEDICAL UNIV
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