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Block polymer for full-degradable intravascular stent and preparation method of block polymer

A technology of block polymers and vascular stents, which is applied in the field of block polymers and preparations of fully degradable vascular stents, which can solve problems such as stent fracture, low melt strength, and difficult melt extrusion processing, and achieve the effect of improving degradation

Active Publication Date: 2021-09-07
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, conventional polylactic acid materials also have some disadvantages, such as the high brittleness of the material itself, which leads to the risk of fracture after implantation
The polylactic acid molecular chain is relatively rigid and has almost no long-chain branching, resulting in low melt strength, which causes many difficulties in the melt extrusion processing of scaffolds

Method used

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  • Block polymer for full-degradable intravascular stent and preparation method of block polymer
  • Block polymer for full-degradable intravascular stent and preparation method of block polymer
  • Block polymer for full-degradable intravascular stent and preparation method of block polymer

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preparation example Construction

[0031] A method for preparing a block polymer for fully degradable vascular stents, comprising the following steps:

[0032] Step 1: The hydroxyl end group in the polylactic acid and carbonyldiimidazole (CDI) react in a solvent to obtain polylactic acid (PLA-CDI) whose end group is carbonylimidazole; the mole of the hydroxyl end group in the polylactic acid and carbonyldiimidazole The ratio is 1:1~1:5. The reaction temperature is from room temperature to 100°C, and the reaction time is from 5h to 24h. The mass concentration of polylactic acid in the solvent is 0.2g / mL-5g / mL. The reaction solvent is one or a mixture of two or more of chloroform, dichloromethane, tetrahydrofuran, hexafluoroisopropanol and acetone in any proportion.

[0033] After the reaction is completed, the purification process is as follows:

[0034] Pour the reaction solution into anhydrous ether or anhydrous methanol, suction filter to obtain the target polymer, and then further purify the target polyme...

Embodiment 1

[0048] A block polymer for fully degradable vascular stents was prepared according to the following steps:

[0049] Step 1: React polylactic acid (Mw=50000) with carbonyldiimidazole in a chloroform solution at room temperature for 24 hours to obtain a polylactic acid material whose end group is carbonylimidazole. The mass concentration of polylactic acid was 1 g / mL.

[0050] Wherein, the molar ratio of polylactic acid hydroxyl group to carbonyldiimidazole is 1:1, after the solvent is concentrated, it is poured into anhydrous methanol, and the polylactic acid material whose target end group is carbonylimidazole is obtained by suction filtration.

[0051] Step 2: React carbonyl imidazole polylactic acid and polycaprolactone (Mw=1000) in chloroform solution for 48 hours at 50°C to obtain a polylactic acid-polycaprolactone block polymer whose linking site is carbonate . Wherein the mass concentration of the polylactic acid of carbonylimidazole is 3g / mL. The molar ratio of polyl...

Embodiment 2

[0054]A block polymer for fully degradable vascular stents was prepared according to the following steps:

[0055] Step 1: React polylactic acid (Mw=80000) with carbonyldiimidazole in a chloroform solution for 24 hours at room temperature to obtain a polylactic acid material whose end group is carbonylimidazole. The mass concentration of polylactic acid is 0.5g / mL.

[0056] Wherein, the molar ratio of polylactic acid hydroxyl group to carbonyldiimidazole is 1:3, after the solvent is concentrated, it is poured into anhydrous methanol, and the polylactic acid material whose target terminal group is carbonylimidazole is obtained by suction filtration.

[0057] Step 2: React carbonyl imidazole polylactic acid and polycaprolactone (Mw=2000) in chloroform solution for 48 hours at 80°C to obtain a polylactic acid-polycaprolactone block polymer whose linking site is carbonate . Wherein the mass concentration of the polylactic acid of carbonylimidazole is 1 g / mL. The molar ratio of ...

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Abstract

The invention discloses a block polymer for a full-degradable intravascular stent and a preparation method of the block polymer, wherein the preparation method comprises the following steps: step 1, reacting a hydroxyl terminal group in polylactic acid with carbonyl diimidazole in a solvent to obtain polylactic acid with carbonyl imidazole as a terminal group; and step 2, reacting the polylactic acid having the end group being carbonyl imidazole and obtained in the step 1 and the polymer with the end group being hydroxyl in a solvent, to obtain the block polymer with the linkage site being carbonic ester. Through the special reaction activity of carbonyl diimidazole, a method for rapidly and efficiently constructing the block polymer is provided, and efficient coupling of two polymers with hydroxyl functional end groups can be realized under mild conditions, so that the block polymer with a clear molecular structure is formed; and the block polymer has the double adjustable degradation performance and the double adjustable mechanical performance and has the clear structure, and the degradation performance, the toughness and other performances of the target polymer can be effectively improved through the fine adjustment of polymer blocks.

Description

technical field [0001] The invention relates to the field of medical materials and medical devices, in particular to a block polymer used for fully degradable vascular stents and a preparation method. Background technique [0002] At present, vascular stent implantation has become one of the most effective means for the treatment of coronary heart disease. Traditional stent products are non-degradable metal-based drug-coated stents. The non-degradable materials do not match the chemical composition, physical structure and mechanical properties of the surrounding tissue, which can easily lead to late thrombosis and complications caused by permanent stent retention. Fully degradable polymer stents can theoretically avoid a series of adverse events caused by permanent retention of metal stents because they can be gradually degraded to complete absorption. Therefore, the development of fully degradable vascular stents based on polymer materials has become an inevitable trend in...

Claims

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Application Information

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IPC IPC(8): C08G81/00A61L31/06A61L31/14
CPCC08G81/00A61L31/06A61L31/148A61L31/14C08G2230/00C08L87/005
Inventor 王云兵李高参罗日方杨立
Owner SICHUAN UNIV
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