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A manganese dioxide/iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application

A technology of composite nanomaterials and manganese dioxide, which is applied in the field of manganese dioxide/iron platinum composite nanomaterials and its preparation, can solve problems such as limited content, oxygen consumption, and insufficient OH content

Active Publication Date: 2022-05-27
LINYI UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

[0004] However, the above catalytic reactions have their own limitations in practical applications
Due to the H in cells 2 o 2 The content is limited, resulting in insufficient amount of OH catalyzed in the Fenton reaction, which limits the chemokinetic therapy in tumor treatment.
On the other hand, GOx catalyzes the glucose decomposition reaction and needs to consume oxygen, which is obviously contradictory to the acidic and hypoxic environment of tumor tissue itself, which greatly limits the application of this catalytic therapy in tumor treatment.

Method used

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  • A manganese dioxide/iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application
  • A manganese dioxide/iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application
  • A manganese dioxide/iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application

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preparation example Construction

[0029] The invention provides a preparation method of a manganese dioxide / iron platinum composite nanomaterial with synergistic catalytic function, comprising the following steps:

[0030] (1) removing the polar organic solvent after ultrasonically mixing FePt nanoparticles, unsaturated fatty acid and polar organic solvent to obtain a pre-dispersion;

[0031] (2) mix described pre-dispersion liquid with potassium permanganate solution, carry out reduction reaction, obtain MnO 2 @FePt nanomaterials;

[0032] (3) the MnO 2 The @FePt nanomaterial was stirred and mixed with glucose oxidase, bovine serum albumin, and water to obtain a manganese dioxide / iron platinum composite nanomaterial with synergistic catalytic function.

[0033] In the present invention, the FePt nanoparticle, the unsaturated fatty acid and the polar organic solvent are ultrasonically mixed and the polar organic solvent is removed to obtain a pre-dispersed liquid. In the present invention, the particle size...

Embodiment 1

[0056] (1) Preparation of FePt nanoparticles

[0057] Add 0.39g platinum acetylacetonate and 0.35g iron acetylacetonate to 43mL dioctyl ether and 0.78g 1,2-hexadecanediol mixed solution, under argon protection, heat to 110℃, heat for 15 minutes, add 0.22mL Oleylamine and 0.21 mL of oleic acid were heated to 295°C and reacted for 1 hour. After the reaction is completed, centrifugation is performed, and FePt nanoparticles are obtained after washing with ethanol, and the particle size is 3 nm.

[0058] (2) MnO 2 Preparation of @FePt:

[0059] 5 mg of FePt nanoparticles with a particle size of 3 nm were dispersed in 12 mL of chloroform, and 1.5 mL of oleic acid was added thereto after ultrasonication for 5 min. Sonication was continued for 25 min, then the mixture was rotary evaporated to remove chloroform. Finally, the rotary-evaporated solid-liquid mixture was added to 30 mL of potassium permanganate solution with a concentration of 20 mM, and stirred overnight at 25°C. Aft...

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Abstract

The invention provides a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application, belonging to the technical field of antitumor drugs. In the present invention, FePt nanoparticles, unsaturated fatty acids and polar organic solvents are ultrasonically mixed to obtain a mixed solution of FePt nanoparticles and unsaturated fatty acids; in the present invention, the pre-dispersion liquid is mixed with potassium permanganate solution, and the reduction reaction is carried out. The unsaturated fatty acid in the predispersion liquid reduces potassium permanganate to manganese dioxide. Since the unsaturated fatty acid is attached to the surface of FePt nanoparticles, its carboxyl group can combine with manganese dioxide, so that manganese dioxide grows on the surface of FePt nanoparticles. get MnO 2 @FePt nanomaterials. The present invention will MnO 2 @FePt nanomaterials are stirred and mixed with glucose oxidase, bovine serum albumin, and water, and glucose oxidase and bovine serum albumin can be loaded on the surface of manganese dioxide.

Description

technical field [0001] The invention relates to the technical field of antitumor drugs, in particular to a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function and a preparation method and application thereof. Background technique [0002] Tumor has become one of the major diseases threatening human health, and its morbidity and mortality are still rising. At present, the conventional treatment methods for tumors include surgical resection, chemotherapy and radiotherapy, etc. However, these treatments often have disadvantages such as large side effects, high recurrence rate, and low treatment efficiency. [0003] In recent years, many new tumor treatment methods have been developed based on catalytic reactions in vivo, such as chemodynamic therapy and starvation therapy. Among them, chemokinetic therapy uses the Fenton reaction or Fenton-like reaction of inorganic metal nanomaterials to convert hydrogen peroxide (H 2 O 2 ) catalyzes t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/44A61K47/54A61K47/69A61P35/00B82Y5/00B82Y30/00B82Y40/00A61K33/26A61K33/32A61K38/38
CPCA61K47/6923B82Y30/00B82Y5/00B82Y40/00A61P35/00A61K38/443C12Y101/03004A61K38/385A61K47/542A61K33/32A61K33/26A61K2300/00
Inventor 戴志超寇运凯田露胡尊富孙运强郑秀文
Owner LINYI UNIVERSITY
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