A manganese dioxide/iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application

A technology of composite nanomaterials and manganese dioxide, which is applied in the field of manganese dioxide/iron platinum composite nanomaterials and its preparation, can solve problems such as limited content, oxygen consumption, and insufficient OH content
CN113398255BActive Publication Date: 2022-05-27LINYI UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LINYI UNIVERSITY
Publication Date
2022-05-27

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Abstract

The invention provides a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application, belonging to the technical field of antitumor drugs. In the present invention, FePt nanoparticles, unsaturated fatty acids and polar organic solvents are ultrasonically mixed to obtain a mixed solution of FePt nanoparticles and unsaturated fatty acids; in the present invention, the pre-dispersion liquid is mixed with potassium permanganate solution, and the reduction reaction is carried out. The unsaturated fatty acid in the predispersion liquid reduces potassium permanganate to manganese dioxide. Since the unsaturated fatty acid is attached to the surface of FePt nanoparticles, its carboxyl group can combine with manganese dioxide, so that manganese dioxide grows on the surface of FePt nanoparticles. get MnO 2 @FePt nanomaterials. The present invention will MnO 2 @FePt nanomaterials are stirred and mixed with glucose oxidase, bovine serum albumin, and water, and glucose oxidase and bovine serum albumin can be loaded on the surface of manganese dioxide.
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Description

technical field

[0001] The invention relates to the technical field of antitumor drugs, in particular to a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function and a preparation method and application thereof. Background technique

[0002] Tumor has become one of the major diseases threatening human health, and its morbidity and mortality are still rising. At present, the conventional treatment methods for tumors include surgical resection, chemotherapy and radiotherapy, etc. However, these treatments often have disadvantages such as large side effects, high recurrence rate, and low treatment efficiency.

[0003] In recent years, many new tumor treatment methods have been developed based on catalytic reactions in vivo, such as chemodynamic therapy and starvation therapy. Among them, chemokinetic therapy uses the Fenton reaction or Fenton-like reaction of inorganic metal nanomaterials to convert hydrogen peroxide (H 2 O 2 ) catalyzes t...

Claims

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