Traditional Chinese medicine compound acne-removing microemulsion gel as well as preparation method and application thereof

A microemulsion gel and acne-removing technology, applied in the fields of cosmetics and medicine, can solve the problems of increasing the percutaneous penetration of drugs, reducing the skin diffusion barrier, and poor ductility, so as to promote non-scarring healing, inhibit skin aging, and distribute uniform effect

Inactive Publication Date: 2021-09-24
JIANGSU FOOD & PHARMA SCI COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Microemulsions can improve the dissolution rate of drugs, reduce the diffusion barrier of the skin, and increase the transdermal penetration of drugs. The gel can overcome the problems of poor adhesion, poor ductility, and poor durability of microemulsions for transdermal administration.

Method used

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  • Traditional Chinese medicine compound acne-removing microemulsion gel as well as preparation method and application thereof
  • Traditional Chinese medicine compound acne-removing microemulsion gel as well as preparation method and application thereof
  • Traditional Chinese medicine compound acne-removing microemulsion gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The selection of embodiment 1 oil phase

[0034] Get excessive curcumin, berberine, resveratrol, according to the ratio of mass ratio 3:1:1, add 1g propylene glycol monocaprylate successively: Litsea cubeba oil (9:1), medium chain triglyceride: Litsea cubeba oil (9:1), glyceryl caprylate: Litsea cubeba oil (9:1), magnetically stir evenly at room temperature, dissolve with ultrasonic (100Hz, 30min), vortex to mix, put in constant temperature shaker (20±1℃, 72h), then centrifuge (50000r·min -1 , 15min), then filter the sample, take the supernatant and add anhydrous methanol and dilute appropriately, measure the absorbance at 420nm, 340nm, and 306nm with a UV spectrophotometer, and calculate the concentration of curcumin, berberine, and resveratrol at Equilibrium solubility in each medium, the results are shown in Mark 1. The experimental results show that curcumin and berberine have the highest solubility in the mixed oil phase of propylene glycol monocaprylate, while r...

Embodiment 2

[0037] The selection of embodiment 2 tensio-active agents

[0038] Take excess curcumin, berberine, and resveratrol respectively, and add 1 g of polyethylene glycol stearate 15, polyethylene glycol octylphenyl ether, polyoxy In ethylene hydrogenated castor oil, magnetically stir evenly at room temperature, put in a constant temperature shaker (20±1°C, 72h), and then centrifuge (4000r·min -1 , 15min), then filter the sample, take the supernatant and add anhydrous methanol and dilute appropriately, measure the absorbance at 420nm, 340nm, and 306nm with a UV spectrophotometer, and calculate the concentration of curcumin, berberine, and resveratrol at The equilibrium solubility in each medium, the results are shown in Table 2. The experimental results showed that curcumin, berberine, and resveratrol had the highest solubility in polyoxyethylene hydrogenated castor oil, so polyoxyethylene hydrogenated castor oil was selected as the surfactant.

[0039] Table 2 The solubility of e...

Embodiment 3

[0042] The selection of embodiment 3 cosurfactants

[0043] Mix 2 g of polyoxyethylene hydrogenated castor oil with 0.5 g of curcumin solution, and dilute the resulting mixture to 10 g with purified water. Take 2 g of the above solution, add isopropanol, diethylene glycol monoethyl ether, and PEG-400 dropwise to it, and vortex evenly, continue to add dropwise until the system becomes clear, and record the weight of the added co-surfactant It is the required minimum amount; then continue to add dropwise until the transparent solution turns turbid again, record the added co-surfactant weight as the maximum amount, the results are shown in Table 3. The results show that when diethylene glycol monoethyl ether is added dropwise to the system, the amount needed to make the system clear is the smallest, and the amount required to turn into turbidity is the largest, so it is considered that the auxiliary effect of diethylene glycol monoethyl ether Emulsifies best.

[0044] The solub...

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Abstract

The invention discloses a traditional Chinese medicine compound acne-removing microemulsion gel as well as a preparation method and application thereof, and belongs to the field of preparations. The traditional Chinese medicine compound acne-removing microemulsion gel comprises 5-45% of an oil phase, 20-65% of a surfactant, 20-50% of a cosurfactant, 1-20% of a traditional Chinese medicine compound acne-removing component and 1-10% of a gel matrix, wherein the traditional Chinese medicine compound acne-removing component is a mixture of curcumin, berberine and resveratrol. The curcumin, the berberine and the resveratrol are synergistic and can play roles in removing acnes and fading acne marks. The traditional Chinese medicine compound acne-removing microemulsion gel disclosed by the invention is prepared by taking traditional Chinese medicines as main components, a novel acne-removing formula is invented, and a self-microemulsion with the particle size of less than 70nm is obtained by optimizing a self-microemulsion system; the gel is taken as the matrix, and the transdermal absorption rate is increased by skin administration, so that the transdermal absorption of multiple active components is promoted, and the purpose of slow release and long action can be achieved; the product is good in stability, has very good effects of removing acnes and fading acne marks, and can also fade acne marks and remove acne pits; and the preparation process is simple, low in production cost and suitable for industrial mass production.

Description

technical field [0001] The invention relates to the fields of medicine and cosmetics, in particular to a traditional Chinese medicine compound anti-acne microemulsion gel and its preparation method and application. Background technique [0002] In China, about 83% of people have suffered from acne to varying degrees, and 95.3% of young people have acne, acne, pigmentation, enlarged pores, sensitive skin and other skin problems on their faces. Not only that, but the problem of adult acne caused by various environmental problems is also rampant. Acne is clinically called acne, a chronic inflammatory skin disease of hair follicles and sebaceous glands, and one of the most common diseases in cosmetic dermatology. At present, the main ingredients of beauty products for treating acne on the market are mostly antibiotics, glucocorticoids, salicylic acid, etc. The most common ingredient in Chinese herbal medicine is aloe vera, which has a single ingredient and has certain antibacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06
CPCA61K31/12A61K31/4375A61K31/05A61K9/06A61K47/14A61K47/42A61K47/36A61K47/10A61K47/44A61K47/38A61K47/32A61P17/10A61P31/04A61K8/042A61K8/35A61K8/4973A61K8/347A61K8/922A61K8/375A61K8/86A61K8/8147A61K8/731A61K8/733A61K8/736A61K8/817A61K8/8129A61K8/65A61Q19/00A61Q17/005A61K2800/5922A61K2800/596A61K2300/00
Inventor 王巧玲张艺任雅涵徐凝月赵骏弘徐蒋奕
Owner JIANGSU FOOD & PHARMA SCI COLLEGE
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