Application of acetal phosphatidyl ethanolamine in preparation of product for reducing trimethylamine oxide in vivo

A technology of plasmalogen phosphatidylethanolamine and trimethylamine oxide, applied in medical preparations containing active ingredients, food science, organic active ingredients, etc., can solve the problems of no research attention, achieve broad market prospects, and reduce the level of effect

Active Publication Date: 2021-10-01
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, plasmalogen phosphatidylethanolamine also has important physiological functions such as promoting membrane structure changes and information transmission, and plays a very important...

Method used

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  • Application of acetal phosphatidyl ethanolamine in preparation of product for reducing trimethylamine oxide in vivo
  • Application of acetal phosphatidyl ethanolamine in preparation of product for reducing trimethylamine oxide in vivo
  • Application of acetal phosphatidyl ethanolamine in preparation of product for reducing trimethylamine oxide in vivo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Effect of plasmalogen phosphatidylethanolamine on content of trimethylamine oxide in mice

[0027] 1.1 Experimental method

[0028] 1.1.1 Experimental design

[0029] ICR mice were divided into 5 groups: normal group, antibiotic group, EPA-phospholipid group, EPA-plasma phosphatidylethanolamine group. The normal control group was given drinking water and common rod-shaped feed; the antibiotic group was given mixed antibiotic solution (1 mg / ml ampicillin and 0.5 mg / ml neomycin sulfate) and common rod-shaped feed, and the antibiotic water was changed every two days; the EPA-phospholipid group Drinking water and rod-shaped feed containing 1% EPA-phosphatidylethanolamine; EPA-plasma-phosphatidylethanolamine group were given drinking water and rod-shaped feed containing 1% EPA-plasma-phosphatidylethanolamine. After 20 days of intervention with the test substance, 45 μM d9-choline chloride was administered to the stomach, blood was collected from the tail vein...

Embodiment 2

[0045] Embodiment 2: Effect of plasmalogen phosphatidylethanolamine on content of trimethylamine oxide in mice

[0046] 2.1 Experimental method

[0047] 2.1.1 Experimental design

[0048] ICR mice were divided into three groups: normal group, sphingomyelin group, EPA-plasma phosphatidylethanolamine group. The normal group received drinking water and common rod-shaped feed; the sphingomyelin group received drinking water and rod-shaped feed containing 1% sphingomyelin; feed. After 30 days of intervention with the test substance, 45 μM d9-choline chloride was administered into the stomach, blood was collected from the tail vein, and the concentrations of d9-TMA and TMAO in serum at different time points were detected by LC-MS.

[0049] 2.1.2 Sample pretreatment

[0050] Take 20uL of serum, add 4 times the volume of cold methanol, vortex and shake for 30s, and sonicate in an ice-water bath for 5min. After ultrasonication, centrifuge at 12000rpm for 15min, take 50uL of the su...

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Abstract

The invention belongs to a novel application of acetal phosphatidyl ethanolamine, and particularly relates to an application of acetal phosphatidyl ethanolamine in preparation of a product for reducing trimethylamine oxide in vivo. EPA acetal phosphatidyl ethanolamine is included. Experiments prove that the plasmalogen can effectively regulate the specific intestinal flora for converting choline into TMA and remarkably reduce the TMA and TMAO levels in vivo, the effect of the plasmalogen in reducing trimethylamine oxide in vivo is verified, and a new way is provided for reducing the level of trimethylamine oxide in vivo.

Description

Technical field: [0001] The invention belongs to the new use of plasmalogen phosphatidylethanolamine, and specifically relates to the application of plasmalogen phosphatidylethanolamine in the preparation of products for reducing trimethylamine oxidation in vivo. Background technique: [0002] A large number of studies have shown that trimethylamine-N-oxide (TMAO) is closely related to cardiovascular diseases, metabolic syndrome, chronic kidney and other diseases, and plays an important role in human metabolism. Specific gut flora can metabolize dietary choline to trimethylamine (TMA), and then TMA is activated by liver-containing flavin monooxygenases (FMO) to generate TMAO. Therefore, it is very necessary to find substances that can regulate specific intestinal flora to reduce the production of trimethylamine oxide in the body. [0003] Plasmalogen phosphatidylethanolamine (PPE) is a glycerophospholipid with an ene ether bond at the sn-1 position and an unsaturated fatty ...

Claims

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Application Information

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IPC IPC(8): A61K31/685A23L5/20
CPCA61K31/685A23L5/27
Inventor 张恬恬邹宏宇王玉明薛长湖姜晓明唐庆娟毛相朝常耀光薛勇李兆杰徐杰王静凤
Owner OCEAN UNIV OF CHINA
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