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Preparation method of acesulfame potassium

A technology of acesulfame potassium and acetoacetamide, which is applied in the field of preparation of acesulfame potassium, can solve the problems of many impurities in the product and the inability to effectively improve the reaction conversion rate, etc., and achieve the goal of simplifying the process, reducing production costs and shortening the reaction time Effect

Pending Publication Date: 2021-10-15
ANHUI JINGHE IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these technologies still cannot effectively improve the conversion rate of the reaction, and at the same time cannot solve the problem that the product (ASH) obtained after hydrolysis of the cyclization and cyclization product has many impurities

Method used

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  • Preparation method of acesulfame potassium
  • Preparation method of acesulfame potassium
  • Preparation method of acesulfame potassium

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preparation example Construction

[0026] The preparation method of acesulfame potassium provided by the application is implemented by a combined reactor, the combined reactor includes a Venturi reactor and a flow reactor, and the outlet of the diffuser section of the Venturi reactor is connected with the inlet of the flow reactor.

[0027] figure 1 It is a schematic cross-sectional structure diagram of a Venturi reactor 100 according to an embodiment of the present application, from figure 1 It can be seen from the figure that the structural size of the Venturi reactor 100 has an important influence on the flow rate of the injection fluid and the mixing effect between the working fluid and the injection fluid. Such as figure 1 As mentioned above, the Venturi reactor is mainly composed of nozzle 1, suction chamber 2, mixing section 3, and diffuser section 4.

[0028] The preparation method of acesulfame potassium provided by the application is carried out using the above-mentioned Venturi reactor, the differe...

Embodiment 1～ Embodiment 5

[0082] Sulfonated cyclization step: use acetoacetamide-N-sulfonic acid triethylamine salt solution as working fluid, dissolve sulfur trioxide in solvent to form cyclizing agent solution as injection fluid; working fluid from Venturi reactor The nozzle enters, and the injection fluid enters from the suction chamber of the Venturi reactor. In each embodiment, please refer to Table 1 for the pressure of the working fluid and the pressure of the injection fluid; make the working fluid and the injection fluid in the Venturi reactor The mixing section and the diffuser section are mixed to carry out the sulfonation ring closure reaction, and the sulfonation ring closure product is sprayed into the flow reactor.

[0083] Hydrolysis step: the sulfonated cyclization product is subjected to a hydrolysis reaction with an aqueous ethanol solution preset in a flow reactor to obtain a hydrolyzate solution; and

[0084] Salt-forming step: adding potassium hydroxide to the organic phase of the...

Embodiment 6

[0091] Sulfonated cyclization step: use acetoacetamide-N-sulfonic acid triethylamine salt solution as working fluid, dissolve sulfur trioxide in solvent to form cyclizing agent solution as injection fluid; working fluid from Venturi reactor The nozzle enters, and the injection fluid enters from the suction chamber of the Venturi reactor. In each embodiment, the pressure of the working fluid is 0.8MPa, the pressure of the injection fluid is 0.4MPa, the reaction temperature is -10 ° C, and the reaction time is 3 second; the working fluid and the injection fluid are mixed in the mixing section and the diffuser section of the Venturi reactor to carry out the sulfonation ring closure reaction, and the sulfonation ring closure product is sprayed into the flow reactor.

[0092] Hydrolysis step: the sulfonated cyclization product is hydrolyzed with ethanol aqueous solutions of different mass fractions preset in the flow reactor to obtain a hydrolyzate solution; for the specific mass fr...

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Abstract

The invention discloses a preparation method of acesulfame potassium, which comprises the following steps: taking an acetoacetamide-N-sulfonic acid triethylamine salt solution as a working fluid, and dissolving sulfur trioxide in a solvent to form a cyclizing agent solution as a driving fluid; introducing the working fluid from a nozzle of a Venturi reactor, introducing the driving fluid from an air suction chamber of the Venturi reactor, controlling the pressure of the working fluid to be higher than that of the driving fluid, mixing the working fluid and the driving fluid in a mixing section and a diffusion section of the Venturi reactor, carrying out sulfonation cyclization reaction, and spraying a sulfonation cyclization product into a flow reactor; carrying out hydrolysis reaction on the sulfonation cyclization product and a hydrolysis agent preset in the flow reactor to obtain a hydrolysis product solution; and adding potassium hydroxide into the organic phase of the hydrolysis product solution to obtain acesulfame potassium. According to the method, the probability that organic impurities remained in the final product acesulfame potassium are reduced, the purity of acesulfame potassium is improved, and the method is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of fine chemical manufacturing, and in particular relates to a preparation method of acesulfame potassium. Background technique [0002] Acesulfame potassium (acesulfame potassium), also known as AK sugar, is a widely used sugar substitute food additive. Its appearance is white crystalline powder. As an organic synthetic salt, its taste is similar to sugarcane, and it is easily soluble in water. , Slightly soluble in alcohol, its chemical properties are stable, and it is not easy to break down and fail; it does not participate in the body's metabolism and does not provide energy; it has high sweetness and low price; it has no cariogenicity; it has good stability to heat and acid. [0003] At present, in the synthesis of acesulfame potassium, the diketene-sulfur trioxide method is widely used. The specific reaction steps include: reacting sulfamic acid with amine to form amine sulfamic acid salt, and then rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D291/06
CPCC07D291/06Y02P20/584
Inventor 周睿丁震陈永旭杨峰宝刘刚
Owner ANHUI JINGHE IND