Transfersome-exosome membrane fusion preparation with transdermal enhancement effect as well as preparation method and application thereof

Abstract

The invention discloses a transfersome-exosome membrane fusion preparation with a transdermal enhancement effect as well as a preparation method and the application thereof. The preparation method of the preparation comprises the following steps: extracting and separating mesenchymal stem cell exosome; preparing a small molecule peptide-loaded carrier; constructing a transdermal peptide modified transfersome-exosome membrane fusion carrier loaded with small molecule peptide; preparing plant essential oil gel; and obtaining a transfersome-exosome membrane fusion preparation with the transdermal enhancement effect. The prepared transfersome-exosome membrane fusion preparation can remarkably improve the drug loading capacity of small molecule peptide, has higher deformability and more excellent transdermal effect compared with traditional lipidosome, and has synergistic effect with plant essential oil with transdermal effect to better promote penetration of functional beautifying components into the deep skin. Multiple beautifying effects of tightening skin, recovering skin vitality and the like are expected to be achieved through simple smearing, and the cosmetic is convenient to use, safe, free of pain and non-irritant to skin and has huge application market and development prospects in the medical market.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a transfer body-exosome membrane fusion preparation with enhanced transdermal effect, a preparation method and application thereof. Background technique [0002] The skin is the largest organ of the human body, and the stratum corneum is responsible for resisting external aggression, and thus blocks the absorption of many skin care ingredients. Decreased synthesis and increased loss of collagen in fibroblasts in the dermis will lead to aging phenomena such as sagging and fine lines in the skin. Increased melanin synthesis by melanocytes in the basal layer will cause problems such as dark yellow and spots. However, most skin care products on the market contain ingredients It is single and mainly composed of chemical components. Due to the limitation of the stratum corneum of the skin, it only stays on the surface of the skin, and it is difficult to penetrate into the deep la...

AI Technical Summary

Problems solved by technology

Decreased synthesis and increased loss of collagen in fibroblasts in the dermis will lead to aging phenomena such as sagging and fine lines in the skin. Increased melanin synthesis by melanocytes in the basal layer will cause problems such as dark yellow and spots. However, most skin care products on the market contain ingredients It is single and mainly composed of chemical components. Due to the limitation of the stratum corneum of the skin, it only stays on the surface of the skin, and it is difficult to penetrate into the deep layer of the skin to play a role on specific cells, causing waste and affecting the actual use effect of the user.

[0003] As far as skin care products are concerned, if the active ingredients exist alone, they are easily affected by pH, oxidation, and interaction with other ingredients, resulting in reduced self-efficacy

CN202010292807.2 provides an essence with whitening and freckle-removing functions, which contains a variety of whitening compositions combining Chinese and Western: Mimeng flower extract (0.1-10%), sealwort extract (0.1-10%), magnolia extract extract (0.1-10%), Moutan bark extract (0.1-10%), phloretin (0.05-2%), 4-n-butylresorcinol (0.01-0.3%), vitamin C or its Derivatives (0.05-2%), niacinamide (0.05-2%), vitamin E (0.03-1%), etc., in addition to containing 5-20% moisturizers, 1-5% skin conditioning agents, 0.1-5 % solubilizer, 0.1-1% thickener, 0.02-2% preservative, but the carrier advantage is not obvious enough, it is difficult to guarantee the stability and effectiveness of multiple whitening ingredients

CN104083318A provides a whitening skin care product and its preparation method, wherein the whitening ingredients only account for 0.5-1.5%, and there are problems such as limited penetration effect, and there is still a lot of room for improvement in the whitening effect

[0004] Emerging medical aesthetic methods such as micro-needle, water light needle and other physical methods can deliver active ingredients to the deeper skin to a certain extent, but they will cause skin damage such as bleeding and irritation. After use, the repair cycle is long and there are many precautions, so it is not suitable for long-term , Repeated use, causing a lot of inconvenience to beauty lovers

Umbilical cord-derived mesenchymal stem cell exosomes can restore the activity of skin fibroblasts and promote collagen regeneration through various cytokines. field application

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