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Membrane material for multi-layer co-extrusion disposable biotechnological bag

A one-time, membrane material technology, applied in the direction of biomass post-treatment, biomass pre-treatment, biochemical cleaning equipment, etc., can solve the problems of high hygroscopicity and poor barrier effect, and achieve strong puncture resistance, easy operation, high efficiency effect

Inactive Publication Date: 2021-11-02
ZHEJIANG JINYISHENGSHI BIOENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

EVOH has high hygroscopicity, and its barrier effect on water vapor is extremely poor. Therefore, EVOH as a barrier layer for cell culture in a humid environment obviously cannot meet the requirements

Method used

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  • Membrane material for multi-layer co-extrusion disposable biotechnological bag
  • Membrane material for multi-layer co-extrusion disposable biotechnological bag
  • Membrane material for multi-layer co-extrusion disposable biotechnological bag

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Multi-layer co-extrusion film material for disposable biotechnology bags prepared by co-extrusion casting method

[0050] In this example, the co-extrusion casting method is used to prepare a disposable biotechnology bag film with a thickness of 325 μm. The composition and structure of the film include the following: figure 1 As shown, it includes protective layer 1, adhesive layer 2, gas barrier layer 3 / 4 / 5, adhesive layer 6 and liquid contact layer 7.

[0051] Among them, the protective layer is a mixture of LDPE and LLDPE, LDPE accounts for 30%, and LLDPE accounts for 70%. LDPE adopts Dow's DOW series, LLDPE adopts American Dow's DOW, and the thickness of this layer is 50 μm.

[0052] Wherein the adhesive layers 2 and 6 are made of EVA, and the EVA is made of Celanese EVA, and the thickness of this layer is 10 μm.

[0053] The gas barrier layers 3 and 5 are aromatic PA, which are made by American DuPont, and the thickness of the layers is 20 μm.

[0054...

Embodiment 2

[0069] Example 2 The multi-layer co-extrusion disposable biotechnology bag film material prepared by co-extrusion casting method

[0070] In this example, the co-extrusion casting method is used to prepare a disposable biotechnology bag film with a thickness of 305 μm. The composition of the film includes the following figure 2 As shown, a protective layer 8 , an adhesive layer 9 , a gas barrier layer 10 / 11 , an adhesive layer 12 and a liquid contact layer 13 are included.

[0071] Wherein the protective layer 8 is a mixture of LDPE and LLDPE, LDPE accounts for 30%, and LLDPE accounts for 70%. LDPE adopts Dow series of Dow, LLDPE adopts American Dow DOW, and the thickness of this layer is 50 μm.

[0072] Wherein the adhesive layers 9 and 12 are made of EVA, the EVA is made of Celanese EVA, and the thickness of this layer is 10 μm.

[0073] The gas barrier layer 10 is aromatic PA, which adopts the relevant brand of DuPont in the United States, and the thickness of this lay...

Embodiment 3

[0084] Example 3 Effects of Different Liquid Contact Layers on the Performance of Disposable Bioprocess Bags

[0085] In this example, the disposable bioprocess bag film material is prepared according to the method of Example 1, that is, PA / EVOH / PA is used as the gas barrier layer, and the LDPE:LLDPE is a mixture of 3:7 to prepare the protective layer, according to the method provided in Example 1 Prepare the film material for disposable biotechnology bags, and adopt the liquid contact layer shown in Table 3 respectively, wherein the thickness is the thickness of the liquid contact layer, investigate the obtained multilayer co-extruded disposable biotechnology bag film material Dissolution of small molecule substances, oxygen, water vapor permeability, tensile strength, puncture resistance, transparency and cell culture effect (biocompatibility).

[0086] Both LDPE and LLDPE use American Dow DOW; ULDPE uses Dow Chemical Engage 8480K series ULDPE.

[0087] Wherein, the detecti...

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Abstract

The invention provides a multi-layer co-extrusion disposable biotechnological bag membrane material and a preparation method thereof. LLDPE and ULDPE are adopted as liquid contact layers, LDPE and LLDPE are adopted as protective layers, a nylon / ethylene-vinyl alcohol copolymer / nylon or nylon / ethylene-vinyl alcohol copolymer composite structure is adopted to prepare a gas barrier layer, and a proper bonding layer and a proper thickness are selected. The prepared disposable biotechnological bag is high in puncture resistance, good in gas barrier property, water resistance, strength, bending resistance and transparency, excellent in heat sealing property, good in biocompatibility, high in cell culture density, excellent in cell culture effect, simple in preparation process, easy and convenient to operate, high in efficiency and suitable for industrial production. The membrane material can be used for preparing disposable bioreactor bags, liquid storage bags, stirring bags, weighing bags, feeding bags and the like.

Description

[0001] This application claims the priority of an earlier Chinese application, application number: 202110644601.6, with an application date of June 9, 2021; all of its content is regarded as a part of the present invention. technical field [0002] The invention belongs to the field of film materials for bioreactors, and in particular relates to a multilayer co-extruded disposable bioprocess bag film material for bioreactors and a preparation method thereof. Background technique [0003] In recent years, disposable technology has been widely used in the biopharmaceutical industry due to its low pollution risk, cleanliness, and ease of use. It not only brings innovative equipment to biopharmaceutical companies, but also helps pharmaceutical companies greatly shorten construction and production time. It brings greater flexibility. At present, disposable reactors can be used for various types of drugs such as antibodies, vaccines, recombinant proteins, cell therapy, and recombi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B32B27/08B32B27/32B32B27/30B32B27/34B32B7/12B29C48/21B65D30/02C12M3/00C12M1/00
CPCB32B27/34B32B27/32C12M23/14B32B27/40B32B27/12B32B5/02B29C55/28B29C41/32C12N5/0686C12N5/0603B32B2262/0261B32B2307/724B32B2250/24
Inventor 杨宇明徐江宁宋金沛
Owner ZHEJIANG JINYISHENGSHI BIOENG CO LTD
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