Gradient degradation medical sponge and preparation method thereof

A sponge and gradient technology, which is applied in the field of medical sponges, can solve problems such as the difficulty in transporting the bleeding point of the cavity to the bleeding position, sponge chipping, and difficulty in precision machining, etc., and achieve the effects of wound pressure to stop bleeding, isolate the wound, and prevent wound adhesion

Active Publication Date: 2021-11-05
诺一迈尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the elastic sponge is in contact with water, it forms a thixotropic hydrogel, which has good elasticity and water absorption. However, this type of sponge is prone to chipping during processing, and it is difficult to process precisely. It is not easy to transport to the bleeding point of the cavity. position, it needs to be compressed or cut into small pieces by external force during transportation

Method used

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  • Gradient degradation medical sponge and preparation method thereof
  • Gradient degradation medical sponge and preparation method thereof
  • Gradient degradation medical sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The method of preparing a medical sponge according to the present embodiment includes the steps of:

[0044] (1) Construction of a rigid structure: in an environment at 60 ℃, 4g of hydroxypropyl cellulose (2% viscosity: 15000mPa.s, 20 ℃) ​​material was added 96g of purified water, stir to dissolve, gel-like, to give hydroxypropyl cellulose hydrogel slurry and the resulting slurry hydroxypropylcellulose hydrogels using 0.5mol / L hydrochloric acid solution was adjusted to pH 2, and then the formaldehyde solution was added 0.1g, mixed thoroughly and allowed to stand 60 ℃ set 4h, to give a 2% viscosity (20 ℃) ​​crosslinked hydroxypropyl cellulose hydrogel slurry of 210000mPa.s.

[0045] (2) Construction of the flexible structure: in an environment at 60 ℃, 4g of sodium carboxymethylcellulose (degree of substitution of 0.5, 2% viscosity: 3500mPa.s, 20 ℃) ​​was added uniformly dispersed in 20g absolute ethanol, followed by addition of 0.05g glyoxal solution, after the crosslinki...

Embodiment 2

[0051] The method of preparing a medical sponge according to the present embodiment includes the steps of:

[0052] (1) Construction of a rigid structure: in a water bath at 40 ℃, 4g of hydroxypropylmethyl cellulose (2% viscosity: 60000mPa.s, 20 ℃) ​​material was added 96g of purified water, stir to dissolve, gel-like to give hydroxypropylmethylcellulose hydrogel slurry and the resulting slurry hydroxypropylmethylcellulose hydrogel using 1mol / L acetic acid pH adjusted to 5 and then added 0.001g glutaraldehyde solution, sufficiently mix well and allowed to stand for 40 ℃ 4h, to give a 2% viscosity (20 ℃) ​​hydroxypropylmethyl cellulose crosslinked hydrogel slurry of 300000mPa.s.

[0053] (2) Graft drugs: 5g of powder was dissolved hydrocortisone from step (1) hydroxypropylmethyl cellulose crosslinked hydrogel slurry was prepared, mixed well and allowed to stand for 2h at 40 ℃.

[0054] (3) Construction of the flexible structure: in a water bath at 40 ℃, 4g of hydroxyethyl cellulo...

Embodiment 3

[0058] The method of preparing a medical sponge according to the present embodiment includes the steps of:

[0059] (1) Construction of a rigid structure: at room temperatures, a 0.8g sodium carboxymethyl cellulose (2% viscosity: 5000mPa.s, 20 ℃) ​​was added 99.2g of purified water, stir to dissolve, gel-like, to give sodium carboxymethyl cellulose hydrogel slurry and the resulting slurry-hydrogel 1mol / L of phosphoric acid to adjust the pH to 3, followed by addition of 0.001g epichlorohydrin solution, mixed thoroughly and allowed to stand at room temperature 4h, to give a 2% viscosity (20 ℃) ​​crosslinked sodium carboxymethylcellulose hydrogel slurry of 120000mPa.s.

[0060] (2) Graft drugs: 5mg of mometasone furoate, dissolved in step (1) cross-linked sodium carboxymethylcellulose hydrogel slurry obtained thoroughly mixed and allowed to stand at room temperature 2h.

[0061] (3) Construction of the flexible structure: environment at room temperature, 4g of hydroxyethyl cellulos...

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Abstract

The invention discloses a gradient degradation medical sponge and a preparation method thereof. The preparation method comprises the following steps: a step of constructing a rigid part, namely the step of providing a first water-soluble cellulose derivative, and cross-linking the first water-soluble cellulose derivative to form hydrogel slurry with first viscosity; a step of constructing a flexible part, namely the step of providing a second water-soluble cellulose derivative, and cross-linking the second water-soluble cellulose derivative to form a hydrogel slurry with a second viscosity, the second viscosity being less than the first viscosity; and a step of constructing a composite structure, namely the step of mixing the hydrogel slurry with the first viscosity and the hydrogel slurry with the second viscosity to form mixed slurry; and carrying out vacuum freeze drying treatment on the mixed slurry to form the sponge. The sponge has the rigid structure and the flexible structure, so that the sponge is extremely high in elasticity and strong in supporting force after absorbing water. The sponge can realize an instantaneous hemostasis function, and can realize gradient degradation regulation and quantitative release of loaded medicines.

Description

Technical field [0001] The present invention relates to a medical sponge, particularly, the present invention relates to a shapeable medical sponges and method for preparing a gradient degradation. Background technique [0002] Chronic sinusitis with polyps (CRSwNP) affect up to 4% of the world population, which is characterized by the presence of benign inflammatory polyps (polyps) in the sinus or nasal cavity of the liner, which can block the normal air flow and cause nasal congestion , runny nose, headache, tearing and discomfort, causing serious impact on the patient's work and life. To solve these problems, functional endoscopic sinus surgery (FESS) is one of the most important CRSwNP treatment techniques. But now there is usually surgical treatment such as surgery to stop bleeding, scarring and inflammation, can not completely remove the pain point at issue mucosal inflammation and high relapse again after many clinical difficult to effectively solve. [0003] To solve the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/62A61L15/42A61L15/44
Inventor 李强李明朱晓强
Owner 诺一迈尔(山东)医学科技有限公司
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