Adhesive hydrogel and preparation method thereof

A hydrogel and adhesion technology, applied in the field of polymer biomaterial preparation, can solve problems such as lack of adhesion of hydrogels, achieve enhanced adhesion effect, enhanced adhesion strength and mechanical properties, and increased adhesion force effect

Pending Publication Date: 2021-11-05
武汉新思邦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the above-mentioned technical deficiencies, provide an adhesive hydrogel and its preparation method, and solve the technical problem that the hydrogel lacks adhesiveness in the prior art

Method used

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  • Adhesive hydrogel and preparation method thereof
  • Adhesive hydrogel and preparation method thereof
  • Adhesive hydrogel and preparation method thereof

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preparation example Construction

[0024] This specific embodiment provides a kind of preparation method of adhesive hydrogel, comprising the following steps:

[0025] S1, according to the mass ratio of chitosan and caffeic acid 1:1-2, chitosan solution and caffeic acid solution are mixed, then dialyzed, rotary steamed, and dried to obtain modified chitosan; wherein, the caffeic acid solution Prepared by the following steps: dissolve caffeic acid in ethanol solution and stir, then add EDC according to the mass ratio of caffeic acid and EDC 1:2-2.5 to activate; the chitosan solution is prepared by the following steps: Dissolving chitosan in a glacial acetic acid solution with a pH of 3-3.5 to obtain the chitosan solution; the temperature of rotary steaming is 60-70°C;

[0026] S2. Dissolving the modified chitosan in water at 80-90°C to obtain a modified chitosan solution, and then mixing and stirring the modified chitosan solution and polyvinyl alcohol solution to obtain a hydrogel precursor ;

[0027] S3. Add...

Embodiment 1

[0033] This embodiment proposes an adhesive hydrogel, which is prepared by the following steps:

[0034] S1. Add the caffeic acid solution into the chitosan solution, protect it with nitrogen gas, avoid light for 24 hours, dialyze in a deionized aqueous solution with pH=4 for three days, perform rotary evaporation at 65°C, and dry to obtain modified chitosan , and stored in a desiccator for subsequent use; wherein, the caffeic acid solution is prepared by the following steps: 3g caffeic acid is dissolved in 300mL ethanol solution (the volume ratio of ethanol and water is 1:1) and stirred, and then added 6.5 gEDC is obtained by activating magnetic stirring for 1 h; the chitosan solution is prepared by the following steps: dissolving 6 g of chitosan in 600 mL of glacial acetic acid solution with a pH of 3 to obtain the chitosan solution; the temperature of rotary steaming is 70° C. ;

[0035] S2. Dissolving the modified chitosan in water in a water bath at 80°C to obtain a modi...

Embodiment 2

[0042] This embodiment proposes an adhesive hydrogel, which is prepared by the following steps:

[0043] S1. Add the caffeic acid solution into the chitosan solution, protect it with nitrogen gas, avoid light for 24 hours, dialyze in a deionized aqueous solution with pH=4 for three days, perform rotary evaporation at 65°C, and dry to obtain modified chitosan , and stored in a desiccator for subsequent use; wherein, the caffeic acid solution is prepared by the following steps: 3g caffeic acid is dissolved in 300mL ethanol solution (the volume ratio of ethanol and water is 1:1) and stirred, and then added 7.5 gEDC is obtained by activating magnetic stirring for 1 h; the chitosan solution is prepared by the following steps: dissolving 3 g of chitosan in 600 mL of glacial acetic acid solution with a pH of 3 to obtain the chitosan solution; the temperature of rotary steaming is 60° C. ;

[0044] S2. Dissolving the modified chitosan in water in a water bath at 90°C to obtain a modifi...

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Abstract

The invention discloses adhesive hydrogel and a preparation method thereof, and belongs to the technical field of preparation of macromolecular biological materials. The preparation method of the adhesive hydrogel comprises the following steps: S1, mixing a chitosan solution and a caffeic acid solution, and then performing dialysis, rotary evaporation and drying to obtain modified chitosan; s2, mixing and stirring the modified chitosan solution and a polyvinyl alcohol solution to obtain a hydrogel precursor solution; and S3, dropwise adding an oxidized konjac glucomannan solution into the hydrogel precursor solution, and stirring to obtain the adhesive hydrogel. The invention also discloses the adhesive hydrogel prepared by the preparation method. The adhesive hydrogel prepared by the preparation method has relatively good adhesion.

Description

technical field [0001] The invention relates to the technical field of polymer biomaterial preparation, in particular to an adhesive hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a gel with a three-dimensional network structure that can hold a large amount of water, and can maintain its original structure when absorbing a large amount of water. It has good water retention, biocompatibility, biodegradability and non-toxicity. Toxicity, etc., are widely used in tissue engineering, medical materials, wound accessories, hemostatic materials, drug sustained release carriers, etc. If the hydrogel has a certain degree of adhesion, when used as a wound dressing material, it can provide a closed and moist environment for the wound, which is conducive to wound healing, but the existing hydrogel lacks adhesion. Contents of the invention [0003] The purpose of the present invention is to overcome the above-mentioned technical deficiencies, prov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/00C08L5/08C08L29/04C08K5/13
CPCC08J3/075C08J2305/00C08J2405/08C08J2429/04C08K5/13
Inventor 樊李红陈晓静郭远东刘爽胡志海王有丽
Owner 武汉新思邦生物科技有限公司
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