Disinfectant composition, preparation method therefor, and use thereof

A disinfectant and composition technology, applied in the field of alcohol-based virus-killing disinfectant and its preparation, can solve the problems of vaccine research and production lag

Pending Publication Date: 2021-11-09
SHAANXI GAOYUAN IN VITRO DIAGNOSTIC REAGENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, due to the lack of specific therapeutic drugs for viral infections, the research and production of vaccines are seriously lagging behind, which poses a severe challenge to the prevention and control of diseases

Method used

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  • Disinfectant composition, preparation method therefor, and use thereof
  • Disinfectant composition, preparation method therefor, and use thereof
  • Disinfectant composition, preparation method therefor, and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0086] 1, a virus disinfectant, it comprises by mass percentage:

[0087]

[0088] The balance is water, preferably deionized water.

[0089] 2. The disinfectant composition according to paragraph 1, wherein the content of ethanol is 59%-88%, preferably 70%.

[0090] 3. The disinfectant composition according to any one of the preceding paragraphs, wherein the content of isopropanol is 1.5%-8%, preferably 5.5%.

[0091] 4. The disinfectant composition according to any of the preceding paragraphs, wherein the content of urea is 0.2%-8%, preferably 2%.

[0092] 5. The disinfectant composition according to any of the preceding paragraphs, wherein the organic acid includes citric acid, salicylic acid, acetic acid, lactic acid, etc., preferably citric acid.

[0093] 6. The disinfectant composition according to any of the preceding paragraphs, wherein the organic acid content is 0.2%-6%, preferably 2%.

[0094] 7. The disinfectant composition according to any one of the precedi...

Embodiment 1-4

[0142] Embodiment 1-4: the preparation of product

[0143] The products of Examples 1-4 and Comparative Examples 1-5 were prepared according to the raw material composition and method described in Table 1 below.

[0144] Raw materials and composition of table 1, embodiment 1-4 and comparative example 1-5

[0145]

[0146]

[0147] The preparation method of embodiment 1 or 3: (a) mix ethanol and isopropanol and stir; (b) then sequentially add urea, citric acid, borneol into (a) solution, stir until completely dissolved; ( c) Add polyethylene glycol 200, oleic acid, and eucalyptol to the solution of (b) respectively, and stir while adding, so that the solution is evenly mixed; (d) add the zinc salt into deionized water, and stir until completely dissolved ; (e) Slowly add (c) solution to (d) solution, and stir rapidly to mix the solution evenly to obtain a homogeneous and clear liquid. The above-mentioned steps are all carried out under normal pressure, and the temperatu...

Embodiment 5

[0151] Embodiment 5: the effect test of the composition of embodiment 1-4

[0152] Get above-mentioned each composition 250ml / bottle * 15 bottles, according to " technical specification for disinfection " (2002 edition), Pharmacopoeia of the People's Republic of China (two) (2015 edition), GB27951-2011 " hygienic requirements for skin disinfectants ", GB26373-2010 "Ethanol Disinfectant Hygienic Standard" and GB27952-2011 "Hygienic Requirements for Common Object Surface Disinfectant", etc., the disinfectant composition of the present invention and the properties of each comparative composition are tested, and the specific results are as follows:

[0153] 1. Suspension Quantitative Bactericidal Test

[0154] The test was carried out in a constant temperature controller at 20°C. Take 4.0mL of disinfectant and add it into the test tube, preheat it with a constant temperature controller at 20°C for 5 minutes, add 1.0mL of bacterial suspension, and let it stand; The drug suspension...

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Abstract

The present invention relates to the field of disinfectants. Provided in the present invention is a disinfectant composition, which comprises, in percentages by mass: 59-88% of ethanol, 1.5-8% of isopropanol, 0.2-8% of urea, 0.2-6% of an organic acid, 0.1-2% of borneol, 0.1-3% of a zinc salt, and the balance of water. The disinfectant composition provided by the present invention can be applied to the surface disinfection of various inanimate objects, and can also be applied to skin disinfection to effectively play a role in killing Staphylococcus aureus, Escherichia coli, Candida albicans, Pseudomonas aeruginosa, poliovirus, adenoviruses, norovirus, polyomavirus, etc. Strict disinfection requirements are met, and no skin irritation is caused.

Description

technical field [0001] The invention relates to the field of disinfectants, in particular to an alcohol-based virucidal disinfectant for animate and inanimate surfaces and a preparation method thereof. Background technique [0002] In recent years, disinfectants have become more and more important: in the medical field, for example in hospitals or medical practices, but also in the food and pharmaceutical industry or in places with heavy public transport, for example in swimming pools or public toilets. Regular use of disinfectants in many places protects humans and animals from pathogens such as bacteria, fungi or viruses and can greatly limit the spread of pathogens. At the same time, this is especially important for the upcoming epidemic. [0003] There are now a variety of commercially available alcohol-based disinfectants against bacteria, fungi, and enveloped viruses (viruses with a lipoprotein envelope). Although most of these disinfectants have broad and relatively...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61K31/19A61K31/194A61K31/40A61K47/08A61K47/10A61K47/22A61K47/14A61K47/12A61K47/18A61P31/04A61P31/10A61P31/02A61P31/12A01N31/02A01N31/06A01N37/36A01N43/36A01N25/02A01P1/00A01P3/00
CPCA61K31/045A61K31/19A61K31/194A61K31/40A61K47/08A61K47/10A61K47/22A61K47/14A61K47/12A61K47/18A61P31/04A61P31/10A61P31/02A61P31/12A01N31/02A01N31/06A01N37/36A01N43/36A01N25/02A61K2300/00A01P3/00A01P1/00A01N37/02A01N59/16A01N65/24A01N65/12A01N65/00Y02A50/30
Inventor 李科童永光刘凯杨翠霞
Owner SHAANXI GAOYUAN IN VITRO DIAGNOSTIC REAGENT CO LTD
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