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Compound oxytetracycline oculentum for pets and preparation method thereof

A technology of compound oxytetracycline and oxytetracycline hydrochloride, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, ointment delivery, etc., can solve problems such as conjunctival ulcers, difficult implementation, complicated preparation, etc., and achieve obvious results , the effect of clear ingredients

Pending Publication Date: 2021-12-14
南京联智医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few products on the pet market for the treatment of pet eye infections, and most of them are eye drops, which have a short retention time in the conjunctival sac and need to be used regularly and repeatedly
In addition, when dogs have infectious eye diseases, they often have conjunctival or corneal ulcers. Using eye drops will undoubtedly increase the friction and pain on the ulcer surface.
[0006] The invention patent application document with the publication number CN107691854A discloses a pet eye ointment for helping dogs and cats to eliminate eye inflammation and accelerate the tissue repair of cornea and conjunctiva. The eye ointment made by etc. is an edible health care product, which can improve the shortcoming that pet owners are difficult to implement when applying eye products to pets
[0007] Although the above invention solves the problem that it is difficult to implement when applying ophthalmic products to pets, the eye ointment itself has many ingredients, the preparation is complicated, and its safety needs to be verified. At the same time, the eye ointment can only improve the ocular symptoms of pets. To reduce the inflammatory response, it is necessary to use eye antibiotics in addition to achieve better results

Method used

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  • Compound oxytetracycline oculentum for pets and preparation method thereof
  • Compound oxytetracycline oculentum for pets and preparation method thereof
  • Compound oxytetracycline oculentum for pets and preparation method thereof

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preparation example Construction

[0028] A preparation method for compound oxytetracycline eye ointment for pets, comprising the steps of:

[0029] S1, pulverizing oxytetracycline hydrochloride and polymyxin B sulfate to obtain oxytetracycline hydrochloride and polymyxin B sulfate powder;

[0030] S2, heating and melting the white petrolatum, filtering, and drying and sterilizing the liquid paraffin and white petrolatum, the sterilization condition is to dry and sterilize at 150° C. for 1 hour;

[0031] S3. Put oxytetracycline hydrochloride and polymyxin B sulfate powder in a mortar, and add oxytetracycline hydrochloride and polymyxin B sulfate powder 1-3 times the volume of liquid paraffin and eye ointment base to complete the grinding process, and then Supplement the eye ointment base to 1kg and grind it evenly.

Embodiment 1

[0034] prescription:

[0035]

[0036] Preparation:

[0037] 1) Ultrafine pulverization of oxytetracycline hydrochloride and polymyxin B sulfate to 70um to obtain ultrafine powders of oxytetracycline hydrochloride and polymyxin B sulfate for subsequent use;

[0038] 2) Take 10.0g of oxytetracycline hydrochloride ultrafine powder and 2.5g of polymyxin B sulfate ultrafine powder into a sterile mortar, add 20-40ml of sterilized liquid paraffin to grind into a fine paste, then add 20g Grind the rest of the sterilized eye ointment base evenly, then add the remaining eye ointment base in equal amounts to 1000g, grind it evenly, divide into packages, and get ready.

Embodiment 2

[0040] prescription:

[0041]

[0042] Preparation:

[0043] 1) Ultrafine pulverization of oxytetracycline hydrochloride and polymyxin B sulfate to 50um, to obtain ultrafine powders of oxytetracycline hydrochloride and polymyxin B sulfate, for subsequent use;

[0044] 2) Take 8.5g of oxytetracycline hydrochloride ultrafine powder and 1.0g of polymyxin B sulfate ultrafine powder into a sterile mortar, add 10-30ml of sterilized liquid paraffin to grind into a fine paste, then add 10g Grind the rest of the sterilized eye ointment base evenly, then add the remaining eye ointment base in equal amounts to 1000g, grind it evenly, divide into packages, and get ready.

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Abstract

The invention provides a compound oxytetracycline oculentum for pets, the compound oxytetracycline oculentum comprises, by mass, 0.5-5% of an active component and 95-99.5% of an oculentum matrix, the active component comprises oxytetracycline hydrochloride and polymyxin B sulfate, and the oculentum matrix comprises albolene and liquid paraffin. The raw materials and the auxiliary materials are medicinal, the quality is easy to control, and the preparation is convenient; the active ingredients are anti-infection western medicine ingredients which are clear and are safer than some complex traditional Chinese medicine ingredients; and the compound oxytetracycline oculentum for pets has an obvious effect on treating eye infection of pets.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound oxytetracycline eye ointment for pets and a preparation method thereof. Background technique [0002] With the continuous advancement of my country's urbanization process, the phenomenon of population aging is becoming more and more serious. Pets, as human companion animals, play an important role in resolving loneliness and eliminating stress, and their number is increasing. At the same time, the prevention and treatment of pet diseases are increasingly valued by pet owners. Eye infections in dogs and cats are the most common eye diseases in pets, and can occur in all types of dogs and cats. Streptococcus, Rickettsia, Escherichia coli, Bacillus aerogenes, etc. may all become pathogenic bacteria of infectious eye diseases in dogs and cats, and then cause conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis, etc. in pets. Pathogenic bacterial infection ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K31/65A61K9/06A61P27/02A61P31/00
CPCA61K38/12A61K31/65A61K9/06A61K9/0048A61K47/06A61P27/02A61P31/00A61K2300/00
Inventor 任思琪牛犇杭夏清
Owner 南京联智医药科技有限公司
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