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Hemostatic composite material and preparation method thereof

A technology of composite materials and thrombin, which is applied in the field of biomedical materials, can solve the problems of poor fluidity of fibrin composite powder, complicated clinical operation, complicated preparation process, etc., achieve antibacterial wound healing function, accelerate wound healing function, preparation method simple effect

Inactive Publication Date: 2021-12-14
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the existing problems of complex preparation process, high cost and complicated clinical operation of the existing fibrin adhesive in the background technology, and the problems of poor fluidity, easy aggregation and no antibacterial effect of the fibrin composite powder, the present invention provides A hemostatic composite material and a preparation method thereof are disclosed. The hemostatic composite material prepared by the present invention has fast hemostatic speed, antibacterial and wound surface healing functions, and the whole preparation process of the present invention is simple and the cycle is short

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  • Hemostatic composite material and preparation method thereof
  • Hemostatic composite material and preparation method thereof

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Embodiment 1

[0030] A preparation method of a hemostatic composite material, comprising the steps of:

[0031] (1) Preparation of Component A: Ultrasonic dispersion of mesoporous silicon with a pore size of 25 nm and nanometer zinc oxide with a particle size of 30 nm in a solution containing coagulation factor XIII and fibrinogen, so that the content of the mesoporous silicon is 10mg / ml, the content of the nano-zinc oxide is 0.2mg / ml; then stirred at room temperature for 30 minutes, then suction filtered, and then vacuum-dried at 37°C for 150 minutes to obtain component A; In the solution of factor XIII and fibrinogen, the content of the coagulation factor XIII is 10IU / ml, and the content of the fibrinogen is 25mg / ml;

[0032] (2) Preparation of component B: ultrasonically disperse mesoporous silicon with a pore size of 25 nm and nano-zinc oxide with a particle size of 30 nm in a solution containing thrombin and calcium chloride, and make the content of the mesoporous silicon 10 mg / ml, t...

Embodiment 2

[0035] A preparation method of a hemostatic composite material, comprising the steps of:

[0036] (1) Preparation of Component A: Ultrasonic dispersion of mesoporous silicon with a pore size of 30nm and nano-zinc oxide with a particle size of 20nm in a solution containing coagulation factor XIII and fibrinogen, so that the content of the mesoporous silicon is 20mg / ml, the content of the nano-zinc oxide is 0.4mg / ml; then stirred at room temperature for 35 minutes, then suction filtered, and then vacuum-dried at 40°C for 130 minutes to obtain component A; In the solution of factor XIII and fibrinogen, the content of the coagulation factor XIII is 15IU / ml, and the content of the fibrinogen is 30mg / ml;

[0037](2) Preparation of component B: ultrasonically disperse mesoporous silicon with a pore size of 20 nm and nano-zinc oxide with a particle size of 60 nm in a solution containing thrombin and calcium chloride, and make the content of the mesoporous silicon 20 mg / ml, the conte...

Embodiment 3

[0040] A preparation method of a hemostatic composite material, comprising the steps of:

[0041] (1) Preparation of Component A: Ultrasonic dispersion of mesoporous silicon with a pore size of 20 nm and nanometer zinc oxide with a particle size of 50 nm in a solution containing coagulation factor XIII and fibrinogen, so that the content of the mesoporous silicon is 30mg / ml, the content of the nano-zinc oxide is 0.6mg / ml; then stirred at room temperature for 40 minutes, then suction filtered, and then vacuum-dried at 35°C for 150 minutes to obtain component A; In the solution of factor XIII and fibrinogen, the content of coagulation factor XIII is 20IU / ml, and the content of fibrinogen is 35mg / ml;

[0042] (2) Preparation of component B: ultrasonically disperse mesoporous silicon with a pore size of 30 nm and nano-zinc oxide with a particle size of 40 nm in a solution containing thrombin and calcium chloride, and make the content of the mesoporous silicon 30 mg / ml, the conte...

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Abstract

The invention discloses a hemostatic composite material and a preparation method thereof. The preparation method comprises the following steps of (1) dispersing mesoporous silicon and nano zinc oxide in a solution containing a blood coagulation factor XIII and fibrinogen, and performing stirring, suction filtration and drying to obtain a component A; (2) dispersing mesoporous silicon and nano zinc oxide in a solution containing thrombin and calcium chloride, and performing stirring, suction filtration and drying to obtain a component B; and (3) mixing the component A with the component B to obtain the hemostatic composite material. The mesoporous silicon and the nano zinc oxide are used as raw materials, the mesoporous silicon rapidly absorbs water to accelerate rapid dissolution of loaded components, and a reaction is started to promote formation of fibrin glue, so that rapid hemostasis is realized; and the mesoporous silicon is used as a carrier, so that the flowability of the hemostatic composite material can be remarkably improved, accurate administration is easier, and the hemostatic effect is further improved. The nano zinc oxide has the functions of resisting bacteria and accelerating wound healing, so that the treatment effect can be further improved. The hemostatic composite material prepared by the method disclosed by the invention has remarkable clinical advantages.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hemostatic composite material and a preparation method thereof. Background technique [0002] Difficulty suturing clinical wound bleeding and postoperative suture oozing often bring troubles to the completion of surgery and postoperative recovery of patients. Choosing a suitable medical adhesive can effectively solve this problem. Fibrin adhesive is a local hemostatic drug, which is used as an auxiliary treatment for burn wounds, abdominal incisions in general surgery, hemorrhage in liver surgery wounds and vascular surgery wounds. In addition, it also has the functions of tissue sealing and promoting wound healing. effect. The fibrin adhesive is composed of four components: fibrinogen lyophilized powder and its diluent, thrombin lyophilized powder and its diluent, the whole preparation process is long and cumbersome, the clinical use operation is complicated, and...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/00A61L24/02
CPCA61L24/02A61L24/106A61L24/108A61L24/0015A61L24/0042A61L2400/04A61L2400/12A61L2300/252A61L2300/254A61L2300/418A61L2300/102A61L2300/10C08L89/00
Inventor 张理火周平
Owner FUDAN UNIV
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