Oral ulcer hydrogel sticker film with temperature-controlled adhesion and administration functions and preparation method of oral ulcer hydrogel sticker film

Abstract

The invention belongs to the technical field of oral ulcer dressings and provides an oral ulcer hydrogel sticker film with temperature-controlled adhesion and administration functions and a preparation method of the oral ulcer hydrogel sticker film. A temperature control unit interacts with a catechol derivative adhesion unit capable of being tightly adhered in a wet environment and a biocompatible biological base material separately to form the hydrogel sticker film with a three-dimensional network structure, and a medicine unit capable of treating oral ulcer can be added. According to the hydrogel sticker film, not only can adhesion be controlled through a temperature, but also physical-embedding and controllable release of a drug can be carried out.

Description

technical field [0001] The invention belongs to the technical field of oral ulcer dressings, and in particular relates to an oral ulcer hydrogel film for temperature-controlled adhesion and administration and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "mouth sore", is a common ulcerative injury disease that occurs in the oral mucosa, and is more common in the inner lip, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. Oral ulcers are cyclical, recurrent, and self-limiting. They can occur throughout the year and generally heal within 7-10 days. [0003] In order to relieve the pain of patients with oral ulcers, the current drugs mainly include docaine gel, spray, benzalin...

AI Technical Summary

Problems solved by technology

[0003] In order to relieve the pain of patients with oral ulcers, the current drugs mainly include docaine gel, spray, benzalin spray, chlorhexidine gargle, cediiodine tablets, Bingboran powder, watermelon cream, etc.; but these Drugs only carry out antibacterial treatment and treatment on ulcer wounds and cannot effectively protect the wounds, and patients still feel pain in the process of eating, speaking, etc., and drugs cannot effectively act on oral ulcer wounds. The saliva enters the digestive tract, thereby reducing the effective duration of the drug in the mouth and reducing the efficacy of the drug

[0004] There are also a variety of oral ulcer films on the market, but these films exist, the adhesive surface is not very sticky, and they are easy to fall off; in the wet environment of the oral cavity, they cannot effectively adhere; after the adhesion falls off and is eaten by mistake, it will cause adverse reactions to the body , so it is difficult to solve the actual problems of oral patients

[0005] For example, Chinese patent document CN110179771A discloses a marine herbal biofilm for oral ulcers, which mainly uses hydrophilic groups such as sodium alginate to combine with the oral mucosa and cannot adhere for a long time, while another Chinese patent document CN107515152A Disclosed is an oral ulcer patch that mainly relies on the hydrogen bond interaction between sodium alginate and polyvinyl alcohol, acts on the oral cavity, has a short adhesion time, and cannot effectively protect

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