Application of cerium oxide nano-enzyme with active oxygen scavenging capacity in treatment of alopecia

A technology of cerium oxide and nano-enzyme, which is applied in the application field of nano-biological materials, can solve the problems of side effects, incomplete cure of hair loss, and recurrence, and achieve the effect of promoting hair regeneration, improving the microenvironment of hair follicles, and removing active oxygen

Inactive Publication Date: 2022-02-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although these drugs can relieve hair loss, they cannot completely cure hair loss, and relapse often occurs after discontinuation, so patients need to use drugs for a long time
At the same time, these drugs are often accompanied by serious side effects

Method used

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  • Application of cerium oxide nano-enzyme with active oxygen scavenging capacity in treatment of alopecia
  • Application of cerium oxide nano-enzyme with active oxygen scavenging capacity in treatment of alopecia
  • Application of cerium oxide nano-enzyme with active oxygen scavenging capacity in treatment of alopecia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Synthesis of cerium oxide nanozyme with active oxygen scavenging ability

[0036] (1) Synthesis of cerium oxide nanozyme:

[0037] Add 0.4g of cerium acetate hydrate and 3.2g of oleylamine into 15ml of xylene and stir for 12 hours to form a complex. The temperature of the reactant is raised to 90°C at a rate of 2°C per minute, and 1ml of deionized water is injected into the In the reaction system, aging at 90°C for 3 hours, acetone precipitation, and centrifugation to obtain cerium oxide nanoparticles.

[0038] The result is as figure 1 As shown, the morphology of cerium oxide nanoparticles was characterized by transmission electron microscopy, and the particle size was about 1-8 nm.

[0039] like figure 2 As shown, the X-ray diffractometer was used to characterize the structure of cerium oxide nanoparticles, which showed that the cerium oxide nanoparticles had good crystallinity.

[0040] like image 3 As shown, the structural characterization of ceriu...

Embodiment 2

[0046] Embodiment 2: Therapeutic effect of intradermal injection of cerium oxide nanozyme on hair loss

[0047] Preparation of medicine: disperse the cerium oxide nanozyme prepared in Example 1 into phosphate buffer to prepare a cerium oxide nanozyme solution.

[0048] Group settings:

[0049] a. Control group: After the back hair was removed, only androgen was applied every day for a total of 28 days.

[0050] b. Cerium oxide nano-enzyme group: After removing the back hair, apply androgen every day for a total of 28 days. At the same time, 100 μl of cerium oxide nanozyme solution (90 μg / ml) was injected intradermally on the first, fourth, seventh, tenth and fourteenth days after the back hair was removed.

[0051] The result is as Figure 7As shown, the back hair of the mice in the control group did not grow significantly within 28 days after depilation, while the back hair of the mice in the cerium oxide nanozyme group regenerated significantly. It shows that intradermal...

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Abstract

The invention discloses application of cerium oxide nano-enzyme with active oxygen scavenging capacity in treatment of alopecia, the size of the cerium oxide nano-enzyme is 8-30nm, the cerium oxide nano-enzyme is composed of cerium oxide nano-particles with the surfaces modified with polyethylene glycol, and the size of the cerium oxide nano-particles is 1-5nm. The cerium oxide nano-enzyme provided by the invention can simulate the activity of catalase and superoxide dismutase, remove active oxygen in a hair follicle microenvironment and relieve oxidative stress, so that repair of damaged or atrophic hair follicles is facilitated, and hair growth is promoted. The cerium oxide nano enzyme provides a new strategy for developing a novel medicine for treating alopecia diseases.

Description

technical field [0001] The invention relates to the application of nano-biological materials, in particular to the application of a cerium oxide nano-enzyme with active oxygen scavenging ability in the treatment of hair loss. Background technique [0002] Hair loss has become one of the important reasons affecting the quality of life of many people under the influence of many factors such as fast pace of life in modern society, fierce job competition, and high life pressure. The life cycle of hair follicles on the human scalp can be divided into a resting phase, an anagen phase and a shedding phase. Among them, about 14% of the hair follicles are in the telogen phase, 84% of the hair follicles are in the growth phase, and 2% of the hair follicles are in the shedding phase. Therefore, under normal circumstances, due to the periodic changes of hair follicles, people will naturally lose a certain amount of hair every day. After the anagen period, new hair grows back. Alopeci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/244A61K9/51A61K47/10A61P17/14A61P17/18
CPCA61K33/244A61K9/5146A61P17/14A61P17/18
Inventor 李方园高建青凌代舜夏凡袁安然
Owner ZHEJIANG UNIV
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