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New application of atractylodes macrocephala koidz polysaccharide

A technique for Atractylodes Rhizoma Polysaccharide and Spleen Deficiency, which is applied in regulating the steady state of intestinal flora structure in Spleen Deficiency syndrome and its application. In the field of Atractylodes Rhizoma Polysaccharide, it can solve problems such as unsatisfactory effects.

Pending Publication Date: 2022-02-22
陈磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although studies have shown that some traditional Chinese medicines for invigorating the spleen can regulate the imbalance of intestinal flora, such as Shenlingbaizhusan and Sijunzi Decoction, clinical practice has proved that their effects are still unsatisfactory
Although there are also reports that the polysaccharides in Atractylodes macrocephala can proliferate intestinal Lactobacillus and Bifidobacterium, but for reducing the ratio (F / B) of the relative abundance of Firmicutes and Bacteroidetes in the intestine, it can regulate spleen deficiency. The role of intestinal bacteria homeostasis in the population to improve obesity and hyperuric acid symptoms has not been reported

Method used

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  • New application of atractylodes macrocephala koidz polysaccharide
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  • New application of atractylodes macrocephala koidz polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Main drug: Atractylodes macrocephala crude polysaccharide with a commercially available content of 35%. This crude polysaccharide is done HPLC fingerprint analysis by the analysis method provided by Experimental Example 1, and there are 5 characteristic peaks altogether in the Atractylodes Rhizome polysaccharide fingerprint collection, the relative peak area of ​​No. 1 peak (Rha) is 0.18; The relative peak area of ​​No. 2 peak (GalA) Peak area is 0.26; No. 3 peak (Glu) is a reference peak, and the relative peak area is 1; No. 4 peak (Gal) relative peak area is 0.18; No. 5 peak (Ara) relative peak area is 0.25, and with experimental example 1 The similarity of the HPLC standard fingerprints of Atractylodes macrocephala polysaccharides provided is greater than 88%. Add 75-80 times the volume of distilled water to the commercially available Atractylodes macrocephala polysaccharide, and add trichloroacetic acid:n-butanol (volume ratio 1:8-10) with the same volume as the dis...

Embodiment 2

[0141] Main drug: Atractylenolides macrocephala koidz. crude polysaccharide extracted from Atractylenolides macrocephala koidz. (purity: 50%). The specific extraction method is: take Atractylodes rhizome powder and add appropriate amount of water (w / v, 1:10), extract at 90°C for 3 hours, repeat the extraction twice, combine the filtrate, after standing still, collect the filtrate after vacuum filtration, and concentrate it into an extract. . After the extract is cooled to room temperature, add 4-5 times the volume of 95% ethanol alcohol to precipitate the polysaccharide, and after 12 hours, suction-filter to obtain the crude polysaccharide of Atractylodes macrocephala, add 2 times the volume of water to dissolve, then alcohol-precipitate, and obtain the crude polysaccharide after suction , with a purity of 50%, dried in an oven at 60°C, and used for later use. This crude polysaccharide is done HPLC fingerprint analysis by the analysis method provided by Experimental Example 1...

Embodiment 3

[0145] Main drug: Atractylenolides macrocephala koidz. crude polysaccharide extracted from Atractylenolides macrocephala koidz. (purity: 30%). Take an appropriate amount of Atractylodes rhizome powder, add water (w / v, 1:10), extract at 90°C for 3 hours, repeat the extraction twice, combine the filtrate, after standing still, collect the filtrate after vacuum filtration, and concentrate into an extract. After the extract was cooled to room temperature, 4-5 times the volume of 95% ethanol alcohol-precipitated polysaccharide was added, and after 12 hours, the crude polysaccharide of Atractylodes macrocephala was obtained by suction filtration with a purity of 30%, dried in an oven at 60°C, and used for later use. The Atractylodes Rhizoma Atractylodes Rhizome crude polysaccharide is done HPLC fingerprint analysis by the analysis method provided by Experimental Example 1, and there are 5 characteristic peaks altogether in the Atractylodes Rhizoma Atractylodes Rhizome polysaccharide ...

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Abstract

The invention aims to disclose new application of atractylodes macrocephala polysaccharide, namely application of the atractylodes macrocephala polysaccharide in preparation of health care products or functional foods for reducing the ratio of relative abundance of intestinal bacteria firmicutes F to bacteroides B of spleen-deficiency people, regulating the balance of the intestinal bacteria F / B and preventing or treating obesity caused by spleen-deficiency intestinal bacteria disorder. The obesity further comprises symptoms such as hyperuricemia and the like. The atractylodes macrocephala polysaccharide is heteropolysaccharide composed of five monosaccharides including rhamnose (Rha), galacturonic acid (GalA), glucose (Glu), galactose (Gal) and arabinose (Ara) and has specific fingerprint characteristics. The invention provides a brand-new weight-losing product with a wide application prospect, and atractylodes macrocephala polysaccharide is safe and effective for preventing and treating the symptoms.

Description

technical field [0001] The invention relates to a new application of Atractylodes macrocephala polysaccharide, in particular to regulating the structural stability of intestinal flora of spleen deficiency syndrome and its application, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] The intestinal flora is a huge ecosystem, and the number of cells in a normal adult is 10 13 , and the number of bacteria in the intestinal tract is about 10 times that of the total number of body cells, which is 10 14 indivual. In addition, the gut microbial genome has about 100 to 150 times the number of genes encoded in the human genome. Microorganisms can not only exchange information with each other, but also contact host cells, and at the same time participate in the regulation of their metabolism, gene and protein expression. The bacteria antagonize and cooperate with each other to maintain the balance between health and disease. The imba...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/00A61P3/04A61P19/06A61P1/14A23L33/21G01N30/86
CPCA61K31/715A61P1/00A61P3/04A61P19/06A61P1/14A23L33/21G01N30/8686A23V2002/00A23V2200/3202A23V2200/332A23V2200/30A23V2250/51
Inventor 不公告发明人
Owner 陈磊
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