Method for preparing N, N-diisopropylethylamine

Abstract

The invention discloses a preparation method of N, N-diisopropylethylamine, which comprises the following step of: performing a reaction on ethanol and diisopropylamine as raw materials through the catalysis of a catalyst in a fixed bed reactor under the atmosphere of hydrogen to obtain N, N-diisopropylethylamine and simultaneously obtain diethylamine, triethylamine and isopropanol as by-products. The method for preparing N, N-diisopropylethylamine is simple in process, low in cost, high in conversion rate and good in selectivity. Meanwhile, gas-solid phase reaction is adopted in the method, corrosion of liquid-phase materials to reaction equipment under high-temperature and high-pressure conditions is avoided, the requirement for equipment materials is low, and full-continuous production can be achieved. Unreacted ethanol and diisopropylamine can continue to return to the reaction system as raw materials, and the obtained diethylamine, triethylamine and isopropanol can be sold as byproducts after being rectified and purified.

Description

technical field [0001] The invention belongs to the field of organic chemical intermediates, in particular to a method for preparing N,N-diisopropylethylamine. Background technique [0002] N,N-Diisopropylethylamine is an important organic chemical intermediate, which is mainly used in the following aspects: (1) an important pharmaceutical and pesticide synthesis intermediate; (2) can also be used as a condensation Mixing agent, such as for the condensation reaction of carbon monoxide, amine and alkyl halide to form urethane; (3) As a catalyst for ester hydrolysis and other reactions. [0003] According to comprehensive literature reports, there are currently three main synthetic methods for N,N-diisopropylethylamine: [0004] 1) Patent CN101759571 reports a method to generate DIPEA by reacting diisopropylamine and alkyl halide, the reaction pressure is 0.4-2.5MPa, and the yield is about 95%. However, the reaction generates salt, which requires high equipment stirring, and...

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Problems solved by technology

However, the reaction generates salt, which requires high equipment stirring, and the reaction generates hydrogen halide, which is corrosive to the equipment, and the cost of wastewater treatment is very high;

[0005] 2) In the document "Synthesis of N,N-diisopropylethylamine", a method for synthesizing DIPEA with diisopropylamine and diethyl sulfate as raw materials is reported, with a yield of 90% and a simple process. The commonly used route, but diethyl sulfate is more toxic and seriously pollutes the environment;

But the catalyst is expensive and the yield is low

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