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Preparation method of hyaluronic acid honey dew

A technology of hyaluronic acid bee and honeydew, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and medical formulas. , the effect of improving compliance

Pending Publication Date: 2022-03-01
武汉自然萃创新科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are two main clinical methods for the treatment of chronic constipation: Western medicines mainly include fruit guide tablets, liquid paraffin, Sepiride tablets, magnesium sulfate, etc.; these western medicines are mostly lubricants, diluents and stimulant laxatives. , often palliative

Method used

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  • Preparation method of hyaluronic acid honey dew

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of hyaluronic acid honey dew, the preparation method is:

[0023] Step 1. Preparation of modified mercaptopolyethylene glycol folic acid: 12g of mercaptopolyethylene glycol folic acid and 40g of ethanol were added to the reaction kettle, stirred and mixed evenly at 40°C, and 5g of chlorophyll was mixed under nitrogen protection. Alcohol, 0.5g of sodium ethoxide is added to the reaction kettle, and the addition modification reaction is carried out at a temperature control of 55°C for 60 minutes, and then the heat preservation reaction is continued for 60 minutes, the ethanol is evaporated, and the modified mercaptopolyethylene glycol folic acid can be obtained after drying;

[0024] Step 2. Preparation of liquid preparation: Add 0.4g of modified mercaptopolyethylene glycol folic acid, 0.2g of soybean oil and 0.3g of propylene glycol stearate to 45g of pure water, stir and mix at 50°C for 30min, then add 1.3g For hyaluronic acid, adjust the pH value t...

Embodiment 2

[0027] A preparation method of hyaluronic acid honey dew, the preparation method is:

[0028] Step 1. Preparation of modified mercaptopolyethylene glycol folic acid: 17g of mercaptopolyethylene glycol folic acid and 50g of ethanol were added to the reaction kettle, stirred and mixed evenly at 50°C, and 8.5g of folic acid was mixed under nitrogen protection. Green alcohol, 0.8g of sodium ethoxide is added to the reaction kettle, the addition modification reaction is carried out at a temperature control of 60°C for 150 minutes, and then the heat preservation reaction is continued for 90 minutes, the ethanol is evaporated, and the modified mercaptopolyethylene glycol folic acid can be obtained after drying;

[0029] Step 2. Preparation of liquid preparation: Add 0.1 g of modified mercaptopolyethylene glycol folic acid, 0.04 g of palm oil and 0.1 g of propylene glycol stearate to 40 g of pure water, stir and mix at 40° C. for 30 minutes, and then add 0.1 g For hyaluronic acid, adj...

Embodiment 3

[0032] A preparation method of hyaluronic acid honey dew, the preparation method is:

[0033] Step 1. Preparation of modified mercaptopolyethylene glycol folic acid: 22g of mercaptopolyethylene glycol folic acid and 60g of ethanol were added to the reaction kettle, stirred and mixed evenly at 60°C, and 12g of chlorophyll was mixed under nitrogen protection. Alcohol, 1.2g of sodium ethoxide was added to the reaction kettle, and the addition modification reaction was carried out at a temperature control of 65°C for 240 minutes, and then the heat preservation reaction was continued for 120 minutes, the ethanol was evaporated, and the modified mercaptopolyethylene glycol folic acid could be obtained after drying;

[0034] Step 2. Preparation of liquid preparation: Add 0.6g of modified mercaptopolyethylene glycol folic acid, 0.4g of olive oil and 0.6g of propylene glycol stearate to 55g of pure water, stir and mix at 60°C for 60min, then add 3g of hyaluronic acid , adjusting the pH...

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Abstract

The invention relates to the field of external medicines, in particular to a preparation method of hyaluronic acid honey dew. The preparation method comprises the following steps: preparing modified sulfydryl polyethylene glycol folic acid, preparing a liquid preparation and preparing hyaluronic acid honey dew. The modified sulfydryl polyethylene glycol folic acid and hyaluronic acid are added into a liquid preparation formula, the glycerine enema is feasible, safe and reliable in preparation method, discomfort of a patient cannot be increased in the using process, the compliance of the patient is improved, and the glycerine enema is a rapid, safe and effective bowel relaxing product.

Description

technical field [0001] The invention relates to the field of medicine for external use, in particular to a preparation method of hyaluronic acid honey dew. Background technique [0002] Constipation is a common disease, frequently-occurring disease. The vast majority of constipation is caused by fast-paced modern lifestyles, such as too fine a diet, lack of enough fiber and too little alcohol, life stress, lack of exercise, and delayed bowel movements. Constipation also occurs during women's pregnancy, and the elderly and women are frequent crowds of constipation. [0003] CN101199629A relates to an external preparation and preparation method for treating constipation. The raw materials are coffee powder and pure ethanol. The coffee powder and pure ethanol are taken to make a solution with a concentration of 1-90%, and the solution is put into a 10-20ml bottle of Kaisailu . The external preparation of the invention has a wide range of sources, obvious clinical effect, sim...

Claims

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Application Information

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IPC IPC(8): A61K35/644A61K31/795A61K31/728A61K47/14A61K47/44A61K9/08A61P1/10C08G65/331
CPCA61K35/644A61K31/795A61K31/728A61K47/14A61K47/44A61K9/08A61P1/10C08G65/3312A61K2300/00Y02A50/30
Inventor 周鹏刘超奇
Owner 武汉自然萃创新科技有限公司
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